ID A0A1Y1UQ30_9TREE Unreviewed; 765 AA.
AC A0A1Y1UQ30;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Tyrosyl-DNA phosphodiesterase-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BD324DRAFT_258111 {ECO:0000313|EMBL:ORX40109.1};
OS Kockovaella imperatae.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cuniculitremaceae; Kockovaella.
OX NCBI_TaxID=4999 {ECO:0000313|EMBL:ORX40109.1, ECO:0000313|Proteomes:UP000193218};
RN [1] {ECO:0000313|EMBL:ORX40109.1, ECO:0000313|Proteomes:UP000193218}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-17943 {ECO:0000313|EMBL:ORX40109.1,
RC ECO:0000313|Proteomes:UP000193218};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Louie K.B., Bewick A.J., Labutti K.,
RA Haridas S., Kuo A., Salamov A., Ahrendt S.R., Lau R., Bowen B.P.,
RA Lipzen A., Sullivan W., Andreopoulos W.B., Clum A., Lindquist E., Daum C.,
RA Northen T.R., Ramamoorthy G., Schmitz R.J., Gryganskyi A., Culley D.,
RA Magnuson J., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Widespread Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the tyrosyl-DNA phosphodiesterase family.
CC {ECO:0000256|ARBA:ARBA00010205}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORX40109.1}.
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DR EMBL; NBSH01000002; ORX40109.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y1UQ30; -.
DR STRING; 4999.A0A1Y1UQ30; -.
DR InParanoid; A0A1Y1UQ30; -.
DR OrthoDB; 930461at2759; -.
DR Proteomes; UP000193218; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd09122; PLDc_Tdp1_1; 1.
DR CDD; cd09123; PLDc_Tdp1_2; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR010347; Tdp1.
DR InterPro; IPR003903; UIM_dom.
DR PANTHER; PTHR12415; TYROSYL-DNA PHOSPHODIESTERASE 1; 1.
DR PANTHER; PTHR12415:SF0; TYROSYL-DNA PHOSPHODIESTERASE 1; 1.
DR Pfam; PF06087; Tyr-DNA_phospho; 1.
DR Pfam; PF02809; UIM; 2.
DR SMART; SM00726; UIM; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50330; UIM; 2.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000193218}.
FT REGION 53..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..80
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 403
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-1"
FT ACT_SITE 646
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-1"
FT BINDING 405
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-2"
FT BINDING 648
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-2"
FT SITE 697
FT /note="Interaction with DNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-3"
SQ SEQUENCE 765 AA; 84396 MW; 888A3BF33BDD1364 CRC64;
MDASRSNGIG SSVPARGRDK TFDRYFDEHF GHDSSEDVDI ADLRRAAWAT WKTAPPAGMN
RPEGTHRRKE EEEDEELARA IAMSVQDQGP SRQNAPIDLT EDSDDEDIQR VLAMSTEEER
SAKRAKRDET PEEERRMLAE AMAASLQPVT PGMRDASAEA GTSEERARLA DASPTDSSIP
SSTTEPRTAS GSPARLVHPR SPAPRLQANG VLGDRAQMEK ERLARQAARE AQTQPQASSS
RSTAPPKVHV SSNLRTFADL SNSSSASSSS TPTAAYSNTQ SADPHHPLQS AGSLPRDAAG
EYYPNGEMRH SALTIGQPSK QKTFSPKQVM GDTSQISLII MSSYVVDDAW IETFLPPADE
VPRVVIRPHP QENHPAWNGK VRAEETGGVA CYPLMVGGLG SAHMKFFWIF YKTGRLRVVI
STGNLVHYDW EWIENTIFIQ DILPIKEPRE TSSASVKMND FAARFCWLFT HLKVHKAVRH
LIANHERGSD IPLDPADGFE CLNKWDWSKV RVQLLMSVPG TYTGSQVDDF GLCRLGKILH
QQGWVPQKNE DVKVEFQGSS LGAYTLDWLD LFYQYCRGKT TSSLLNRPKA IAWPPIKILF
PSLATVDASI LGRDGGGTMF CGKGMNSLTR PLFHDANSKR GGVLMHAKVL IGVFEPRQDN
LGFVKASPSS SKRKASEMEN ESADVGGWVY VGSHNFSPAA WGRPNLKKNP PSLTIANYEL
GIVFPLPRTD TQKAADAIAP HVRPPRPYAN NDVPWDQNIR AQNND
//
