ID A0A1Y1URL2_9TREE Unreviewed; 2029 AA.
AC A0A1Y1URL2;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=BD324DRAFT_611393 {ECO:0000313|EMBL:ORX40582.1};
OS Kockovaella imperatae.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cuniculitremaceae; Kockovaella.
OX NCBI_TaxID=4999 {ECO:0000313|EMBL:ORX40582.1, ECO:0000313|Proteomes:UP000193218};
RN [1] {ECO:0000313|EMBL:ORX40582.1, ECO:0000313|Proteomes:UP000193218}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-17943 {ECO:0000313|EMBL:ORX40582.1,
RC ECO:0000313|Proteomes:UP000193218};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Louie K.B., Bewick A.J., Labutti K.,
RA Haridas S., Kuo A., Salamov A., Ahrendt S.R., Lau R., Bowen B.P.,
RA Lipzen A., Sullivan W., Andreopoulos W.B., Clum A., Lindquist E., Daum C.,
RA Northen T.R., Ramamoorthy G., Schmitz R.J., Gryganskyi A., Culley D.,
RA Magnuson J., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Widespread Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORX40582.1}.
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DR EMBL; NBSH01000001; ORX40582.1; -; Genomic_DNA.
DR STRING; 4999.A0A1Y1URL2; -.
DR InParanoid; A0A1Y1URL2; -.
DR OrthoDB; 147843at2759; -.
DR Proteomes; UP000193218; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 2.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000193218};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1463..1649
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1750..2013
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 21..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 58..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2029 AA; 225167 MW; 53A7A4E1BE5A8FF9 CRC64;
MDCLDEPLHL QILSSLATSL AKSQPEETKA NGDATPNGDV KADDGRLDVI TRGLPEVQSV
SNGTLRSSDD NETEDEDWTE FEINHAISYA HYVVALPLGS PQLKAALRRV KDLLSGLLAQ
GRQSGTNSSP SSSTSQTSEL NLSGTHHQAR LCEQLIKALL WISWTDEASN KIAAEVLNHL
FEDIGELLTT GGSITFPLVL LNSAHLVLSR CSIPALVDGS LATVLDSLLK IASPSNLVKV
LHQNSHHSSF RHAPSRFSFI APHPLTPAGV VTIVSEIANI LLAGSLLPSK DPERRPFMTP
SNIHWTSTGI PEEPDMHHSV LSVQIESLIS QSISLPVEKR LFGQNNTSAI GDEWDKAALK
WWNEASAPMH DGSDTGHGDS GRRESLFSLG EAVVDEEIEM SVTVLHLLNL LNLHREEPSS
THLSRLTMLL SENSTASDCR VFETAFICTS MIVRNHPALG TNMTLHIRRL LMTPLPAFES
GMNCAAGDVP PAVKSASRCL AICIEMSPND DLISSTLYSL LNLLQHGGSA LGSSVAQSLR
SQPAPLRDGE TIGTLSTLSN GKKTEEQKML VALTAVEVVS CLSLDLGRDD IIHLSISLLL
QRLRGVDLMI ESAIVTNLVP LALAASDADV VEVYRAFSQI SRSAHPEDPR MTSNAVLAAQ
TRLARGMVKR LRCAEGYLVD LLSLFADKGT QTQMIAMSGI NFETRDKEKQ ALLKRESEDR
VSDMKAWMGA LFIPLSTLLS HESFNPAKGA SAELVSLFRN FWFLCVAFGL SGPAGEKKLS
EYEWKALGDI AVKTPALVQE DAVDFVDSDL EYNSILRKDF AASIANKNRA TLQEYLASQK
SGYEIRTMSA PQTTLLIAIC DLEQMRAAAF QPSIMLEYFS NESLNSSFLA PPLVTIGQKV
SSTFLKQLSR QVVIHRSPPI VAQETCRVLV ACTHRFRKTR EVARTFAKQI LETFSALLCD
RQVVFTLLEI LTLMRRSCEM QFTDEYSPIH EFKSDKMALT LSLTDDYMAR NEITTQLFEL
ASNWLSLAIS RAPLEVQSTL QSYLNESRDV LLIDSVEMGA GLALHYCKAI STLDRQEAIM
PKIGSWPADS SNLVASQFAA KNYFNGELSG ARHILEQGLS NLQQGSPVES SKAELHAFKT
QMADAVRKVR NKEHFSIPDL RRLLLRASSV LTSSSTVDQD VIHYLVELPM AAFTPLAIAA
GVDAWTWLLR EKPEAEVALL GEISASWLET IRTEKGLFST SMNYADPFAV PVEYSPTDKQ
IINLELAKAK RMLRPHLLLI QVLSSQFQAI KYREPGIMIA LTRLMMRSLG AAHKMSTHPL
AREVRFSLLL FGFQILASSR MEALLELRLR DRLYAAAYAW FSVRPQWSFG SDRIQVGAEI
KLLQDFARAI AEDHVRGDHS TSSMSDRSPA LLIRGSTTLH EYSVQHRDRI KILQLLVENE
ISRLAVWYNP GGETSRGMLA TGALEKGVTN DEWTRLISKA WTLSPSMAVH MGERFKQFTV
QNEIGRLVRS NPKAVVDVPE ALHYLLGEKL SQSNSGALKW LPVWAAVPPV TALAYFQPRF
GNHPLILQYA MRVLEQYPVE LTFFFVPQVV QGLRTDRSGY VERFIFETSK ISQLFCHQII
WNMKANMYKD DNATEPDSMK PMLDRMIDMI VADLSGKAKA FYDTEFTFFD AVTSISGKLR
PFIKASKPEK KAKIDEEMAK IKLEVGVYLP SNPDGVVIDL DRKAGRPLQS HAKAPFMATF
KVQKERLDIE PDSSNDLSDE KALVKRKFDT WISAIFKVGD DCRQDMLALQ VIAMFKNVFT
RIGLVLYLFP YRVTATAPGC GVIDVVPNAT SRDEMGRAKI NDLLAYFIDK YGGVNTVTFQ
KARLNFIQSM AAYSVSCYIL QIKDRHNGNI MIDGEGHIVH VDFGFLFDIG PGGIKFEPNS
FKLNHEMVAL MGGRESQGYK MFTELTIKAF LAIRPHADQL CDACHLMLGT GLPSFKGEGT
IKRLRDRFAL HLNEKQAAEF MMGVIRNAHE NVRSNVYDGF QKLQNGIPY
//
