ID A0A1Y1URS3_9TREE Unreviewed; 854 AA.
AC A0A1Y1URS3;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Protein HIR {ECO:0000256|RuleBase:RU364014};
GN ORFNames=BD324DRAFT_647664 {ECO:0000313|EMBL:ORX40750.1};
OS Kockovaella imperatae.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cuniculitremaceae; Kockovaella.
OX NCBI_TaxID=4999 {ECO:0000313|EMBL:ORX40750.1, ECO:0000313|Proteomes:UP000193218};
RN [1] {ECO:0000313|EMBL:ORX40750.1, ECO:0000313|Proteomes:UP000193218}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-17943 {ECO:0000313|EMBL:ORX40750.1,
RC ECO:0000313|Proteomes:UP000193218};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Louie K.B., Bewick A.J., Labutti K.,
RA Haridas S., Kuo A., Salamov A., Ahrendt S.R., Lau R., Bowen B.P.,
RA Lipzen A., Sullivan W., Andreopoulos W.B., Clum A., Lindquist E., Daum C.,
RA Northen T.R., Ramamoorthy G., Schmitz R.J., Gryganskyi A., Culley D.,
RA Magnuson J., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Widespread Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORX40750.1}.
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DR EMBL; NBSH01000001; ORX40750.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y1URS3; -.
DR STRING; 4999.A0A1Y1URS3; -.
DR InParanoid; A0A1Y1URS3; -.
DR OrthoDB; 5478541at2759; -.
DR Proteomes; UP000193218; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000193218};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 14..46
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 68..102
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 126..167
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 168..209
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 609..794
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 382..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..504
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 854 AA; 93964 MW; AE571AD39A9D2CB2 CRC64;
MRLTRPNWVK HTDDKDRRSP IFSISVHPDG TRLATGGLDK KVKIWSTLPI LDKETDENEA
NHKLLCTMSS HTGSVLAVRW AHHGRFLASG SDDTVIVIWG IDPDGGGRVF GSDEVNVENW
KALTRLVGHT ADIIDLAWSR DDSMMASVGL DKLVWIWDGQ SFDRLRKIDL HGDFVKGVCW
DPVGNFLATQ SDDKTVKIWD TANWNLVHSV SAPFKNSPKS TFFRRLSWSP DGAFIAASNA
MNGPVFVAAV IEREGWNADI SFVGHGNTIQ VAAFNPRLFF REGDDPGRAT ASCMLALGAD
DFSISIWRNT LHKPVVVLAD VFNRPLLDLC WATDGHQLYG CSADGTICAI SFDDAELPEL
AEIEKTELVL NEYGYKPVRK SVPRPIQSQT PVNGFGPQPS GSHVNVIQPR KGKSKAQSLT
SQKRRVELGG FGPPADSHDA FSSGQLQPLG SGQDHTARMF EDAHAAFGDN SAGPSNLGQK
RKASLSNDDH RQYKGRTMGS SRSDVDVKEI RAPRVVVSGD GSRGRTLPVP RVQTLLRVKS
TYDESLYLEA ENSEDAKGKT RVALSQDGQN QWLDFMPGPV IAMVLSESFC AVGCEDGMVM
VYSPAGRHIK LDSSIAEMTG NRDKLFVITA SCTCHILDVK SGKSLFPPVS MSHLLGDHNI
SSISVRPHGV PIITTSHPCA YAYDTMRDAW TPLTSSWWLE SSPLADRRSR PGPSGPLADI
EGEVSRLWKG NQISEGEKPE WWDVALELGH LESKVRAAEL LQSKEEYKFW LIRVAGILGR
EGFRARAEEL IKDLLGPLYS HPGRDAWVST VIGLQRRDLL KQVLTTFAQS TSLSGLAQHY
QGIMKEIAAE ASEL
//
