ID   A0A1Y1V0Q3_9FUNG        Unreviewed;       256 AA.
AC   A0A1Y1V0Q3;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=Oxygen-insensitive NADPH nitroreductase {ECO:0000313|EMBL:ORX44157.1};
GN   ORFNames=BCR36DRAFT_130004 {ECO:0000313|EMBL:ORX44157.1};
OS   Piromyces finnis.
OC   Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC   Chytridiomycota incertae sedis; Neocallimastigomycetes; Neocallimastigales;
OC   Neocallimastigaceae; Piromyces.
OX   NCBI_TaxID=1754191 {ECO:0000313|EMBL:ORX44157.1, ECO:0000313|Proteomes:UP000193719};
RN   [1] {ECO:0000313|EMBL:ORX44157.1, ECO:0000313|Proteomes:UP000193719}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=finn {ECO:0000313|Proteomes:UP000193719};
RG   DOE Joint Genome Institute;
RA   Haitjema C.H., Gilmore S.P., Henske J.K., Solomon K.V., De Groot R.,
RA   Kuo A., Mondo S.J., Salamov A.A., Labutti K., Zhao Z., Chiniquy J.,
RA   Barry K., Brewer H.M., Purvine S.O., Wright A.T., Boxma B., Van Alen T.,
RA   Hackstein J.H., Baker S.E., Grigoriev I.V., O'Malley M.A.;
RT   "Genomes of anaerobic fungi encode conserved fungal cellulosomes for
RT   biomass hydrolysis.";
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ORX44157.1, ECO:0000313|Proteomes:UP000193719}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=finn {ECO:0000313|Proteomes:UP000193719};
RG   DOE Joint Genome Institute;
RA   Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA   Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA   Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA   Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA   Visel A., Grigoriev I.V.;
RT   "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the flavin oxidoreductase frp family.
CC       {ECO:0000256|ARBA:ARBA00008366}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ORX44157.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; MCFH01000047; ORX44157.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y1V0Q3; -.
DR   EnsemblFungi; ORX44157; ORX44157; BCR36DRAFT_130004.
DR   OrthoDB; 1329013at2759; -.
DR   Proteomes; UP000193719; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd02146; NfsA-like; 1.
DR   Gene3D; 3.40.109.10; NADH Oxidase; 1.
DR   InterPro; IPR016446; Flavin_OxRdtase_Frp.
DR   InterPro; IPR029479; Nitroreductase.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   PANTHER; PTHR43425; OXYGEN-INSENSITIVE NADPH NITROREDUCTASE; 1.
DR   PANTHER; PTHR43425:SF2; OXYGEN-INSENSITIVE NADPH NITROREDUCTASE; 1.
DR   Pfam; PF00881; Nitroreductase; 1.
DR   PIRSF; PIRSF005426; Frp; 1.
DR   SUPFAM; SSF55469; FMN-dependent nitroreductase-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000193719}.
FT   DOMAIN          10..168
FT                   /note="Nitroreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00881"
SQ   SEQUENCE   256 AA;  29102 MW;  EEDB0FE349FC1D4B CRC64;
     MNPVIESLFK HHSIRKYKDQ PLEDEKLQLI LKAAQAAPNW CNAQHMSIIV VKDKANKEKL
     AELSLNQPYV AQCSVFLVFC ADFYRTNYMF EKNGVSAEQA QKFMEQLDTL FVCGHEPAIA
     MQNAIVAAES MGLGTVPIGL IRKNSLALVK ELNLPKHVIP MIGLCVGYPD HDPDMKPRLP
     TSAVCFDEKY DTAKSKSGVD EFDVSYNEYL VSRDANNRDE NWSKGLAEKY MQFYGLYEDD
     YELLKQQGFI SIDKKN
//