ID A0A1Y1VXD7_9FUNG Unreviewed; 968 AA.
AC A0A1Y1VXD7;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Subtilisin-like protein {ECO:0000313|EMBL:ORX65947.1};
GN ORFNames=DL89DRAFT_260625 {ECO:0000313|EMBL:ORX65947.1};
OS Linderina pennispora.
OC Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota; Kickxellomycotina;
OC Kickxellomycetes; Kickxellales; Kickxellaceae; Linderina.
OX NCBI_TaxID=61395 {ECO:0000313|EMBL:ORX65947.1, ECO:0000313|Proteomes:UP000193922};
RN [1] {ECO:0000313|EMBL:ORX65947.1, ECO:0000313|Proteomes:UP000193922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12442 {ECO:0000313|EMBL:ORX65947.1,
RC ECO:0000313|Proteomes:UP000193922};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORX65947.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MCFD01000019; ORX65947.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y1VXD7; -.
DR STRING; 61395.A0A1Y1VXD7; -.
DR OrthoDB; 662485at2759; -.
DR Proteomes; UP000193922; Unassembled WGS sequence.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008240; F:tripeptidyl-peptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.20.25.690; -; 1.
DR Gene3D; 2.60.40.3170; -; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR048383; TPPII_Ig-like-1.
DR InterPro; IPR022229; TPPII_Ig-like-2.
DR InterPro; IPR046940; TPPII_Ig-like_sf.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR PANTHER; PTHR43806:SF14; TRIPEPTIDYL-PEPTIDASE 2; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF12580; TPPII; 1.
DR Pfam; PF21223; TPPII_Ig-like-1; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|ARBA:ARBA00022438};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000193922};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 36..484
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 501..577
FT /note="Tripeptidyl-peptidase II first Ig-like"
FT /evidence="ECO:0000259|Pfam:PF21223"
FT DOMAIN 670..810
FT /note="Tripeptidyl peptidase II second Ig-like"
FT /evidence="ECO:0000259|Pfam:PF12580"
FT REGION 873..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..915
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 45
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 253
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 439
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 968 AA; 105483 MW; 91F77D985F0518DD CRC64;
MSGNKTPHTQ FPTHGLLPRA DTQAGDFVRK HPHYDGRGTI VAVLDTGIAP MAMGLHTTTD
GKRKVLDYVD CTGSGDVRLQ APRTNADELV GATGRKLKVN SKWKNPTGEW RVGAKRLYEI
TPDILKEDIK KERQAVFWLT ALPRGLATSR PPKDEDAELK HELEAQREVL KDFGAKYEDP
GPVLDILVFH DGKQWRAAID TQETGDFTGV EALGAYKLTG DIGKLAKRNL FYYTLNFYEE
GKVLSIVANV GSHSTHVAGI IGAHHPDEPQ NDGVAPGAQL LSLMIGDHRV SSLETGTGLT
RAANAIIEHG ADLANMSYGE PSATANSGQW VQLLRKEVIK KHRCIFVSSA GNEGPALSTA
GAPGGASDDI IGVGAYVGYE QIKAEYTMYD TVKDTVFTWS SRGPTADGSR GVDIYAPGSA
ITSYPTYTLQ RLHLANGTSM SSPNLCGCLA LLVSAWKHEF GKEGEPKVSP YRIKNAMMAT
AKQFGDELAG WAGAVGSGVE LESQLKFEYE QRVILSTSES WIKVPEAVYV SSEGRSFDAR
VDPTSLERGR LHVAEILGFD SRNVDRGAIF RIPVTITKPS EVGASGCVRF PALRFQPTEV
VRRFIDVPRV QLAPQTRFTQ YELNTHVTIG HSTYAENGGL AEQSYTKTMK VLGGCTLEPV
SRVDLVAAVR PEYGIKVTAT LDTLRRALRP AVSSITPLTL ERDTHPEAGT AIQQLILDYK
YSTSANGVSI TPRLTGIDSL IYEAWTDNVA LLVFDAKKQR VGAHFGYPRP ITLRRKGDYL
IRVQIRHRSA KDLGGAEAVS IPVEFALASV FTKTVSNVRN SSKSIQLNNI MPVFLKTFAV
NPPKDTVPGD ILRGSLSASP NTADLLLEYV VPSKANEEKQ PDESSTKSSS KKQGDSKKKE
AEESQADKDR KAMQEAMRNL KIEWVKKAQD PDVRTELIRQ LEAEQANDTQ VLACAAGVAG
LRAQDTAD
//
