ID A0A1Y1W6Z7_9FUNG Unreviewed; 4352 AA.
AC A0A1Y1W6Z7;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Pyruvate:ferredoxin oxidoreductase {ECO:0008006|Google:ProtNLM};
GN ORFNames=BCR32DRAFT_330174 {ECO:0000313|EMBL:ORX69317.1};
OS Anaeromyces robustus.
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Neocallimastigomycetes; Neocallimastigales;
OC Neocallimastigaceae; Anaeromyces.
OX NCBI_TaxID=1754192 {ECO:0000313|EMBL:ORX69317.1, ECO:0000313|Proteomes:UP000193944};
RN [1] {ECO:0000313|EMBL:ORX69317.1, ECO:0000313|Proteomes:UP000193944}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S4 {ECO:0000313|EMBL:ORX69317.1,
RC ECO:0000313|Proteomes:UP000193944};
RG DOE Joint Genome Institute;
RA Haitjema C.H., Gilmore S.P., Henske J.K., Solomon K.V., De Groot R.,
RA Kuo A., Mondo S.J., Salamov A.A., Labutti K., Zhao Z., Chiniquy J.,
RA Barry K., Brewer H.M., Purvine S.O., Wright A.T., Boxma B., Van Alen T.,
RA Hackstein J.H., Baker S.E., Grigoriev I.V., O'Malley M.A.;
RT "A Parts List for Fungal Cellulosomes Revealed by Comparative Genomics.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ORX69317.1, ECO:0000313|Proteomes:UP000193944}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S4 {ECO:0000313|EMBL:ORX69317.1,
RC ECO:0000313|Proteomes:UP000193944};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORX69317.1}.
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DR EMBL; MCFG01000419; ORX69317.1; -; Genomic_DNA.
DR STRING; 1754192.A0A1Y1W6Z7; -.
DR OrthoDB; 5474937at2759; -.
DR Proteomes; UP000193944; Unassembled WGS sequence.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016903; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors; IEA:InterPro.
DR GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.40.50.360; -; 17.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.920.10; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR033412; PFOR_II.
DR InterPro; IPR019456; Pyrv-flavodox_OxRtase_EKR.
DR InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR InterPro; IPR011895; Pyrv_flavodox_OxRed.
DR InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR NCBIfam; TIGR02176; pyruv_ox_red; 1.
DR PANTHER; PTHR19384:SF17; NADPH--CYTOCHROME P450 REDUCTASE; 1.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR Pfam; PF10371; EKR; 1.
DR Pfam; PF12838; Fer4_7; 1.
DR Pfam; PF00258; Flavodoxin_1; 17.
DR Pfam; PF17147; PFOR_II; 1.
DR Pfam; PF01558; POR; 1.
DR Pfam; PF01855; POR_N; 1.
DR PRINTS; PR00369; FLAVODOXIN.
DR SMART; SM00890; EKR; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF52218; Flavoproteins; 17.
DR SUPFAM; SSF53323; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 17.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000193944}.
FT DOMAIN 674..704
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 730..759
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 1200..1343
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 1368..1514
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 1548..1693
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 1728..1873
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 1910..2056
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 2087..2230
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 2265..2408
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 2502..2648
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 2683..2827
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 2886..3031
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 3076..3221
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 3266..3411
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 3472..3617
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 3655..3800
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 3845..3989
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 4027..4171
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 4199..4343
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT REGION 3038..3068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3414..3463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3414..3443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3444..3458
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4352 AA; 488718 MW; 01045AC4B0480A80 CRC64;
MDGNEAAATI AYSINDVAFV YPITPSSVMA ECIDNWSSEK RTNIWGNVVK SLEMESEAGV
AGALHGSLSA GALSTSFTSS QGLLLMIPNM FKIAGELLPC VLHVASRAIS THALSIFGDH
SDVMAARSTG WNMLCSDSVQ ASLDMALVAQ MATFQCSLPF IHFFEGFRTS HEISKIKLIS
NNVIKTLVDQ KAIDHFRNRA LNPTHPSAKG SSQGSEFYFQ NAEAANKFYE QVPDIVENCM
NKLNFAVGRR YNLFDYTGPE DATDVIVIMG SGAYVCKSAS EILNQNYGKK TGVLNVRLFR
PWSKKHFLNA LPSTVERIAV LDRCKENGSN GEPLFTDVCT TLFSEPMSKP IKVIGGRYGI
ASKDFTPGMA IAVYENLSSP SPKPKFTVGI DDDVTNLSLP YKNYDTLGNN VIQCLFWGFG
SDGTVGANKD AIKIIGDNTD LYGQAYFAYS AHKSRGITTS HLRFGPDPIN APYLITSADY
IAVHYPGYIS KFDVLSNLKP NGTFVLNTDW PIDELDSHLP YWVKKQLAEK MPKFYIIDAN
KIASEIGLGD HINMIMQSVF FYLAKVIPYN EATSLIKQAI DKTYSSKGGD IIQNNKKCVD
LAISNLKKVQ IPNEWKYVKR DDYFTGIKSL SEFVNNVVVP SHHLKANEIP VSKMPVDGSI
EPGTSKYEKL LSSKVISIYD PDKCIQCNKC TLICPHAAIR PVLLNNEKLK EAPQGFITSL
LKSKKYKLNY RIQVSPYDCT GCTLCVKVCP TKSLSMKPTR KMLKVEDENY KFSQTLPIID
DLFKKESIKG SQFRQPLLEF SGACEGCQET VYVKLLTQLY GDHLLIANAT GCSSIWGLSC
PTNPFTVNKN GYGPAWANSL FEDNAEFGYG IHHAYIQRRE HLKNLMKALI QPDSSIKISK
ELKDLIPKWI KTYDDYDANK KISDKIEKLL SKEKSNDPIL ETLYGHRDLL RKVTTWIIGG
DGWAYDIGYS GVDHVLASGD RLRILVLDTE CYSNTGGQAS KSTPLGAVQF FSKNGKTVNK
KELGLMAMQY RNAYVASVSI AANPQQALKA FVEAEAYPGP SIIIAHSPCQ LHGIRGGMKN
VINEAKLAVD SGYWPLYRYN PLNKDQPFIY ESVKIKNNIA ELLKNENRFS QLIRKNPKYG
QELTKKAQQY YLKRHQHLLT LANEEILKDT SAFTSIQLKP TDHTELSKLN SNLLANIKEL
VILYGTEYGT SEAIAKILVD DAKEHGCPKV TMMEANKFDV NEDLSKIEYL IFICSTTGNG
QFPQNAQIFW DKLSKLQISL PNLKYAVFGL GDSSYAQYCY TAKVVDNKLA ELGAKKIYQL
TLTDDKAKIP IESEVEKWVI NLFKNLNTEK FEHPDLHEKH IDPNLKQLNV INATDKGYSD
VIVSKILSDI MKSGEYNANA YEAKNIDMED LKAMDDVIFV TSTNRNGQLP SNALKFWEEL
SKIDERYNEF KNFKYSILSI EDSSYARSGE SAHILDEKLK SLGGKKMVKT STIDINHDVS
RKDASYDDWI KQILKALDIS DEKKQKNNET GKSSVKQEHP PKTYLDKLDI IYGTETGQSE
VASEMLAEDA ENAGVAEVDI HVADKVTLED LQKMKNVVFI SSTSGEGEFP PNAIEFWDKL
SKATPETTNL KNMNFAVYGL GDSNYSKFCE AARLVNEKLE ILGGNRFYPY TTLDEQSEKD
PEIEVRMWIG DILNKLFLVN KNSDENKIPK NPESSTDKKN INFEPNQICV IYGTELGASE
RIAKLLSEKA LELGIRADAF EADMVKLEDL QKMKNVVFIT STSGDGEFPP NALQFWDKLS
KSTPEIIDLK NMNFTVFGLG DSTYEKFCEA ARLINEKIES LGAKRFFPYT TIDDNAITRN
QDIEVKNWIN GILKKLVILN PQWKFNTYGA SDIKTLEKDS SLPIDVVDEL HVIYGTELGA
SKRIAKMVAK EATDLGLSSV DVVEADKVGL KDLQKMKNVL IITSTSGDGE FPPNALQFWD
RLSKVNPKDM NLNNMQYAVF GLGDTTYEKF CEAARLIDEK LETLGAKRFH PYTTIDDNDI
ARNQDVDVDN WIKAIMKKLH LTNSTTKNTK NIMKPTSEPS MKAKKEFNIL FGTQCGLSED
IAYVIGEEAE KRGYKVTVNG ANKVPMDEFK TMKNILVVTS TVDGTFPPSI FKFYNRITAD
DKNKLNLSNM RYSVLGLGST SKEKFCEASR LINKRLEELG AKVYLPYTTF DDQDKEDIEV
KVEKYMDKLF KAFDSLKDEN VDEKGIDNID EIPSYSNNND NDNEFNILFG TQCGLSEDIA
YVIGEEAEKR GYKVTVNGAN KVPMDEFKTM KNVLVVTSTV DGTFPPSIFK FYNRITADDK
DKLNLSNMRY SVLGLGSTSK EKFCEASRLI NKRLEELGAK VYLPYTTFDD QDKEDIEVKI
EKYMNKLFDV LDKNISVKAS ESKSKISFIN PYQAVKHIIE NLTEKSKVNK NMLTDNQKEI
IKEAKKENKT KEMAQNNENI IPSNNINSKR KKVKAITKEK VLNIVYGTEL GSTEIIANNI
AKSAKENGFI RVNVYEANSV DLYGLIKMPT VLFLMPTSGD GEFPPNAIKF WERLSPETKE
TFDLSHTKFA VLGLGDSSYK QFCKAAKFID KKLSSLGATR IQKFTIIDEN NIEQNPDLVI
EEWQQEIFDK LGAEELDENG NRRDSYPSQS KGPKHDRAVI CDLNIIHGTE SGLAEDLSEM
IGEAALNHGF SKVNVCGANK ILLEDLKQMK YVVIVTTTVD DTFPPSINYF WNRIVEASKK
SIDLSKLKFT VLGLDNRKGQ KFCEAAKLIN SKFEELGAER FFDYTTIDNN NESNVEKEIQ
DYIEELFRTL NHLEDPSSSS YIPKLKPVEK SKQIEKEIVS TSSSTPISEV KKEIKKKTSN
NTIQLLNVIF GTETGSSEAI ADMISEDAKN AGIPEVIIHP ADNVSLNDLK KMKYVAFVTS
TSGEGDFPPN AMEFWDRLSN ATKETTSLSD LKFVVLGLGD SSYEKFCEAG RLVNEKFEQL
GGKRFYPYTT LDEQSDKDPE EVVNQWIQNM LKTLISSENS NDNNINNNND DDKPAIKKSE
PKTQNPIVNN KPVQKLDVIF GTETGSSEAI ADMISEDAQK AGISEVIIHP ADDVSFNDLK
NMENVILVTS TSGEGDFPPN AMEFGDRLSK ATKDNISLEN TRFAVLGLGD SSYEKFCEAA
RLVNEKFEQL GGKRFYPYTT LDDQSDKDPE EVVNQWIQNI LKSLISSEGN NDKNIDINNN
DNKPVIKKSE PKIQNPIVNN KPVQKLDVIF GTETGSSEAI ADMISEDAQK AGISEVIIHP
ADDVSFNDLK NMENVILVTS TSGEGDFPPN AMEFGDRLSK ATKDNISLEN TRFAVLGLGD
SSYEKFCEAA RLVNEKFEQL GGKRFYPYTT LDDQSDKDPE EVVNQWIQNM LKSLNSNSND
KSQNLMEKET QTQSTSKLES KSKLQQEPTS KSDIQEKSKS NMNKNVNYSN SLNIIFGTET
GSSEAVAEMI AKDMKKAGIS EVNVNAADDI NPDNLKEMKN VLFIISTSGE GEFPPNALKF
WNKLTKTTKN DTSLENMKYA VLGLGDSSYE KFCEAARLIN EKFEQLGGKR LHAYTTIDDQ
SEENPEDIVN HWVKDILHEL SCDDNKNINP VNKSIKPEMT IKTPVASSFE PIQLLDVIFG
TETGTSEAVA DMISEDAKKA GIPEVVIHAA DDVNLDDLKK MKYVTLVTST SGEGDFPPNA
MEFWNRLSKT KKETTSLNDM KFAVLGLGDS NYSKFCEAAR LVNEKFEQLG GKRFHSYTTI
DDQSDRDQEE MVNEWIQAML KDLNATVKSN DNINHISYES KTFLASNEKE TNELKIKKCN
TQTELHIIYG TQTNHSKDIA NIMAYNAKNA GYPSVYVHEA NTINVEDLSK MKNIVFITPT
YTGKLPIDTI EFWNRFSKMT KDVMNMSKTK YSVLGLGYST SPRYCTAAKA LNKKFQDLGS
NEFYPYSELD IEHVNNPKQI INEWSGMLLN TLNDIESQET ANSSTLGVSN TLSNNRNLKK
CDLQAELHII FGTKSTHAED AAAIINMDAK DAGFPYVFVH EADTIKAEDL LKMKNIVFIT
STINGDFPPD AIEFWNDISS KTKETMNMSN LKYTILGIGN HERKEFCAAS KKLKQKFQNL
EAVEFYPYTE FDMDHSKDPE VFINNWSEKV LNTLIDKETK EINEDVGRRR LINSNDNQLN
IIFGTESEHA QDVAGMLSDE AKEAGLADIN IFSADRIHMN DLRKMKTLVI VTSTFKGTFP
PNAFEFWKRL NEVDKTTAGL ENLKYAVFGL GDSSKEKFCE AARLLDEKFE NLGAHRFYKY
TTLDKQHQNE EIEIIDQWIQ EILKHINIPQ KK
//
