ID A0A1Y1WGI0_9FUNG Unreviewed; 1170 AA.
AC A0A1Y1WGI0;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Coatomer subunit alpha {ECO:0000256|PIRNR:PIRNR003354};
GN ORFNames=DL89DRAFT_265851 {ECO:0000313|EMBL:ORX72244.1};
OS Linderina pennispora.
OC Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota; Kickxellomycotina;
OC Kickxellomycetes; Kickxellales; Kickxellaceae; Linderina.
OX NCBI_TaxID=61395 {ECO:0000313|EMBL:ORX72244.1, ECO:0000313|Proteomes:UP000193922};
RN [1] {ECO:0000313|EMBL:ORX72244.1, ECO:0000313|Proteomes:UP000193922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12442 {ECO:0000313|EMBL:ORX72244.1,
RC ECO:0000313|Proteomes:UP000193922};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC dilysine motifs and reversibly associates with Golgi non-clathrin-
CC coated vesicles, which further mediate biosynthetic protein transport
CC from the ER, via the Golgi up to the trans Golgi network.
CC {ECO:0000256|PIRNR:PIRNR003354}.
CC -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC beta', gamma, delta, epsilon and zeta subunits.
CC {ECO:0000256|PIRNR:PIRNR003354}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR003354}. Golgi
CC apparatus membrane {ECO:0000256|ARBA:ARBA00004255,
CC ECO:0000256|PIRNR:PIRNR003354}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|PIRNR:PIRNR003354};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004255}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORX72244.1}.
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DR EMBL; MCFD01000003; ORX72244.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y1WGI0; -.
DR STRING; 61395.A0A1Y1WGI0; -.
DR OrthoDB; 20819at2759; -.
DR Proteomes; UP000193922; Unassembled WGS sequence.
DR GO; GO:0030126; C:COPI vesicle coat; IEA:UniProtKB-UniRule.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR CDD; cd22948; Coatomer_WDAD_alpha; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.25.40.470; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR047312; Coatomer_alpha_WD-assoc_reg.
DR InterPro; IPR016391; Coatomer_asu.
DR InterPro; IPR010714; Coatomer_asu_C.
DR InterPro; IPR006692; Coatomer_WD-assoc_reg.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19876; COATOMER; 1.
DR PANTHER; PTHR19876:SF1; COATOMER SUBUNIT ALPHA; 1.
DR Pfam; PF04053; Coatomer_WDAD; 1.
DR Pfam; PF06957; COPI_C; 1.
DR Pfam; PF00400; WD40; 6.
DR PIRSF; PIRSF003354; Coatomer_alpha_subunit; 2.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF101908; Putative isomerase YbhE; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR003354};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW ECO:0000256|PIRNR:PIRNR003354};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|PIRNR:PIRNR003354};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR003354};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR003354};
KW Reference proteome {ECO:0000313|Proteomes:UP000193922};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR003354};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 7..48
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 49..90
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 104..126
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 127..161
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 203..244
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 247..288
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 383..720
FT /note="Coatomer WD associated region"
FT /evidence="ECO:0000259|Pfam:PF04053"
FT DOMAIN 770..1168
FT /note="Coatomer alpha subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06957"
SQ SEQUENCE 1170 AA; 130657 MW; B1AD18530534FD09 CRC64;
MQMLTKFETK SSRVKGVAFH PKRPWILASL HNGSIQLWDY RMGTLLERFE EHEGPVRGIS
FHPSQELFVS GGDDYKVKVW NYRTRRCLFT LQGHLDYVRT ARWIITASDD QTIRIWNWQS
RQCIAVLTGH NHYVMSAEFH PTEDLVVSAC LDQTVRVWDI SGLRQKSAAG AQPVMMADPL
ASQRMGAQGD FFNATDVVVK FVLEGHTRGV NWATFHPTMP LILSCGDDRQ IKIWRMNDSR
AWEVDTCRGH YNNVNSALFH PKREFILSDS EDKTIRVWDT TRRTLLATFR REQDRFWCLT
AHPELNLFAA GHDNGLIVFK LERERPAAAS HHNNLLYVRE SQIRIHDFAN NNDAAMIAIR
SAPAGQYLPP PRSMSFNPAE KAARRGTGTS AIWTGRNRFA VLDKAQQQIL IKDLTNQTTK
TIQPPVTVEA IFPAPGSQIL LATATSVVLY DVQTRQMLGE ISAAPVKYVV WSSDMSSVAL
LCKHTITLAN KHLEQLCQVH ETIRIKSAVW DDSGVLLYTT LNHIKFALPQ GDTGTIRTID
NPIYLVRVKG GDVHCLDREG KVQVIKVDPT EYRFKLALVH RNYEEVSIIA YLQQKGYPEI
ALHFVRDDTA RFELALEQPK PSDKPAYWDK FSQEALRRGH VQMVELAYQR NKAYDRLSFL
YSVTGNITKL GKMQKIAVMR NDLQSRLQNA LYLGDAEERV RVLRESGQLS LAYLTAKTHG
LAEEAEAIRE AAGIDEASIT GVPTKSSLLQ PATPILPAAD LDWPQLRVSK GIFDGKFNFG
DKGAAGPQPG KSRVADLATA DGNDVEEDAG AWGIDEDDDV AGDSRAAAAA GRFDDEDLLD
DDAEEGWGLE DEGELDAELT AEATAAAAAD FVAPQPGTSE LEQWSRNSQL AADQIAAGNF
EQAMKLLRDQ VGIVSFEALK PAFLEIYSAS RAVLTTTPSS EPMRAEATQA SEYLPVQIYS
LTTSLELLQQ AYREMTAGKF EDAQTLFRRL LLSLIFVTVD SSEDAKEVKE LLQISREYVL
ACTVEMERAA LAKQEAGEEN DTRVVELAAY FTHCQMRADH EKLALRSAMN IAYKGKCFIA
AGEFAQRLLD LVPSPKIADR ARKIIALCDR QSVNTLSIEY DARNPFSLCA ASHKPINRGD
ASVECPYCQA VYTPEFNGSV CQVCQIAEAA
//
