ID A0A1Y1X3Z1_9FUNG Unreviewed; 512 AA.
AC A0A1Y1X3Z1;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Galactokinase {ECO:0000256|ARBA:ARBA00019487};
DE EC=2.7.1.6 {ECO:0000256|ARBA:ARBA00012315};
DE AltName: Full=Galactose kinase {ECO:0000256|ARBA:ARBA00029590};
GN ORFNames=K493DRAFT_97511 {ECO:0000313|EMBL:ORX80530.1};
OS Basidiobolus meristosporus CBS 931.73.
OC Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota;
OC Entomophthoromycotina; Basidiobolomycetes; Basidiobolales; Basidiobolaceae;
OC Basidiobolus.
OX NCBI_TaxID=1314790 {ECO:0000313|EMBL:ORX80530.1, ECO:0000313|Proteomes:UP000193498};
RN [1] {ECO:0000313|EMBL:ORX80530.1, ECO:0000313|Proteomes:UP000193498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 931.73 {ECO:0000313|EMBL:ORX80530.1,
RC ECO:0000313|Proteomes:UP000193498};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate
CC + H(+); Xref=Rhea:RHEA:13553, ChEBI:CHEBI:15378, ChEBI:CHEBI:28061,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58336, ChEBI:CHEBI:456216; EC=2.7.1.6;
CC Evidence={ECO:0000256|ARBA:ARBA00035596};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13554;
CC Evidence={ECO:0000256|ARBA:ARBA00035596};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947}.
CC -!- SIMILARITY: Belongs to the GHMP kinase family. GalK subfamily.
CC {ECO:0000256|ARBA:ARBA00006566}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORX80530.1}.
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DR EMBL; MCFE01000736; ORX80530.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y1X3Z1; -.
DR STRING; 1314790.A0A1Y1X3Z1; -.
DR InParanoid; A0A1Y1X3Z1; -.
DR OrthoDB; 177392at2759; -.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000193498; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004335; F:galactokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.20.1440.340; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.3170; -; 1.
DR InterPro; IPR000705; Galactokinase.
DR InterPro; IPR019741; Galactokinase_CS.
DR InterPro; IPR019539; GalKase_N.
DR InterPro; IPR013750; GHMP_kinase_C_dom.
DR InterPro; IPR036554; GHMP_kinase_C_sf.
DR InterPro; IPR006204; GHMP_kinase_N_dom.
DR InterPro; IPR006203; GHMP_knse_ATP-bd_CS.
DR InterPro; IPR006206; Mevalonate/galactokinase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00131; gal_kin; 1.
DR PANTHER; PTHR10457; MEVALONATE KINASE/GALACTOKINASE; 1.
DR PANTHER; PTHR10457:SF7; N-ACETYLGALACTOSAMINE KINASE; 1.
DR Pfam; PF10509; GalKase_gal_bdg; 1.
DR Pfam; PF08544; GHMP_kinases_C; 1.
DR Pfam; PF00288; GHMP_kinases_N; 1.
DR PIRSF; PIRSF000530; Galactokinase; 1.
DR PRINTS; PR00473; GALCTOKINASE.
DR PRINTS; PR00959; MEVGALKINASE.
DR SUPFAM; SSF55060; GHMP Kinase, C-terminal domain; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00106; GALACTOKINASE; 1.
DR PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ORX80530.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000193498};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 34..82
FT /note="Galactokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10509"
FT DOMAIN 149..212
FT /note="GHMP kinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00288"
FT DOMAIN 402..471
FT /note="GHMP kinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08544"
SQ SEQUENCE 512 AA; 57271 MW; 808C031517B09C6E CRC64;
MQQENFVPTT NSVMDIYAES KIPGQIKRYR DLFQEFKTIY GFDPEFVARS PGRVNIIGEH
IDYAGFPVLP MAVDRDCLIA VATTKLDSKV RLANVNPKFT RAEFSFVDKE RIVDIDDTVH
EWTNYFKAGY KGMLESLKLD APVGMFCLMD GSVPSGAGMS SSSALVCTSS IATMIANKKC
LSKNDIVQIA IASERYVGTN GGGMDQTASI MSHADAATFI EFHPKFITTP VHFPATLPAI
SFVVANTMVV ADKVVSAPVC YNLRVVETKV AAMILANKLG LLSERPQTLK EVMDLFFAGS
EEPKYATVTE RWIFRLGRML ELVEQFITQH DGYSLAEMAE AAGLSEDEIH ARFMSKYPVR
ADVFHIYARA IHVYSEALRV VQFRDVCERN QDTVEDSQVV LHQLGRLMNE SQVSCRDNYH
CSCKELDDLT LICRKAGAYG SRLTGAGWGG CTVSMVPEDQ EQEFIQRVKD EYFRPRFPDY
TEEQLSNVIF SSRPSSGAFI YRKRTAINPY GG
//
