ID A0A1Y1XFU7_9FUNG Unreviewed; 1776 AA.
AC A0A1Y1XFU7;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Ketosynthase family 3 (KS3) domain-containing protein {ECO:0000259|PROSITE:PS52004};
GN ORFNames=BCR32DRAFT_266215 {ECO:0000313|EMBL:ORX84593.1};
OS Anaeromyces robustus.
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Neocallimastigomycetes; Neocallimastigales;
OC Neocallimastigaceae; Anaeromyces.
OX NCBI_TaxID=1754192 {ECO:0000313|EMBL:ORX84593.1, ECO:0000313|Proteomes:UP000193944};
RN [1] {ECO:0000313|EMBL:ORX84593.1, ECO:0000313|Proteomes:UP000193944}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S4 {ECO:0000313|EMBL:ORX84593.1,
RC ECO:0000313|Proteomes:UP000193944};
RG DOE Joint Genome Institute;
RA Haitjema C.H., Gilmore S.P., Henske J.K., Solomon K.V., De Groot R.,
RA Kuo A., Mondo S.J., Salamov A.A., Labutti K., Zhao Z., Chiniquy J.,
RA Barry K., Brewer H.M., Purvine S.O., Wright A.T., Boxma B., Van Alen T.,
RA Hackstein J.H., Baker S.E., Grigoriev I.V., O'Malley M.A.;
RT "A Parts List for Fungal Cellulosomes Revealed by Comparative Genomics.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ORX84593.1, ECO:0000313|Proteomes:UP000193944}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S4 {ECO:0000313|EMBL:ORX84593.1,
RC ECO:0000313|Proteomes:UP000193944};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORX84593.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MCFG01000049; ORX84593.1; -; Genomic_DNA.
DR STRING; 1754192.A0A1Y1XFU7; -.
DR OrthoDB; 1330122at2759; -.
DR Proteomes; UP000193944; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000193944};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 866..1300
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 714..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1429..1450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1308..1346
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 714..733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..759
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..786
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1434..1450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1776 AA; 204389 MW; 09BC8012A34C840B CRC64;
MVFIEKCDFR GDKEQERNIV FCGEDEETRK VLKENNIIDR INRRFTLRGD NIAIVAKDNI
LPIPFKSVPH PDYPEPWVTV SFKEFHALIK AMAYVIKRRF DFAPGTRVGV IANSLPITHL
LVYTLWTLRC IVVFIPPKIG NDVKQYWVRH IDIKMIFYDI NFRPFDDDNI NKELNEQCQW
IWKWTYPLTE EDEGISAGKE GINMFYFYDE DFRNEIYNIK LEGKGYYRKG CSEDVLTVVG
TSSSSQAIIK NGQCSKMKFV PWQMVHLGNF SQKSLTIQYE YFSPFFLDIP YHHSMGITCA
LSYNINCGGP IVYHTQQLYE VGFIPEMVLT DIVETKSKVI QLFPFHFVAF KKLFDDKHPK
CEYWSKYLGN GDKSKLFRSG GAPLNPMVKK WFKDTFDIQI ITGCGSSEGG YILHEIVDDE
VLPGEESYIW RRVPWVDFLI LPLNENEPNI GELYTRNEAN VPGYIGRPKP GEFYDSPVPG
MRIDINADEL YVEIDGEKYF KTNDVVRRSP LSGKYKYVSR IDSILTFATG IKMNPMPFEE
TIMSECQNIK KCCLILDSTQ TEVVCFIEPN WNEIIINDDD MKFNTNINPE TLSRDRIKSM
NKIARQQTWD SIYKVLMDDS KSLTNWSKQL TINNIFIIDY GKKFPSTDKG SLSRRVARLQ
YAYVLKYISK LISGEITELP DEDEMESSPI NTEEMKVTFT AKNVDTILNM EVNNDNDKFK
DNNNNNNNNN NNERVNLHKK EEEKIQKEKE IKKEKEDKEK GEEEEEEEIK KENDNKEEVQ
KEEEIQKEEI QKEEEVQKEN KKEKIKSQKV IDDEIDEAIK IIYYSVKEII PSTPEFEDFN
PERPFNFYGI DSLATIKLTN IISRKLGKRY TPAVLFNYGA INNAKSLWMT LLKGKNCVVA
PVKNRDLHTN YVNKPSNQLL PNEHNIPYFG CYDTKSNVAK PSQFDAEFFN CLPDEALSLD
PRHRWILETT WEALENAGIP INSLKNTTTG VFVGINDDHE YSDLLEENGI SIPISSHSNH
PSDIAGRLSY FYNLYGPSYT MDTACSTGAS AIHVACRSLQ NRDCNLCMVT GVKYMYSSKS
LSKACSARMI SPHGRCATFD IDADGFVPGE GCVTYILKRL NDAIEDNDNI LSVIIGSSSG
QSGLRQSISA PSSEGQALNI RKAMEFAQVK PEDISYVEAH GTGTPLGDAM EIHALNEVYA
GTHSKENPLI VGSIKTNIGH TCEVAGLAGL AKVIVSLQHK HIPRNLHFNK PNPDFDLNSI
PIKIPTKTLP WNSLKPGKPL IAQVSSFGLQ GSIIHLIIEE YIPKNISINK NEIKNENENK
NINEKEYEIK NENEDENKNI NENENENHIL TISAKSYAAL IELGYNYINT LERMEEENED
ICDLCYTSNI GREHFNEYRL SAYGKNANEL CNSLEKALDD LENKIHDENK LNHHNNNNNI
SSSPSSSSLS SSRKITQMIN IFIENKNTSI SENIYKLLLE LTLAHPVFKE ALDECDVLIS
EILNNNYSLI DDLVNKGKNS NKNYQIFGII SFYYALSKIL DEELKINQSI NFGYDIGELI
AILLNNGISI RKVFEFLKLV QEKDENSINN WYSEDELEGI TYLASQHRKY KIGDIIPKEY
YINLYQILTT STTINNNNNN NEEEENIKQT FETIANVILD QHDKKYKNIS IFSQNLSMAN
EIKEILLSKC KTNLSTQITD NHIISFFDTE YDDEYEKRIL PRYISNMYNI GNDIDWYAFH
QRINSKNYQK YSLHKINLPN YPFQRSTYWP KIICQN
//
