ID A0A1Y1XIC6_9FUNG Unreviewed; 1348 AA.
AC A0A1Y1XIC6;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Multidrug resistance protein 1 {ECO:0000313|EMBL:ORX85114.1};
GN ORFNames=BCR32DRAFT_265866 {ECO:0000313|EMBL:ORX85114.1};
OS Anaeromyces robustus.
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Neocallimastigomycetes; Neocallimastigales;
OC Neocallimastigaceae; Anaeromyces.
OX NCBI_TaxID=1754192 {ECO:0000313|EMBL:ORX85114.1, ECO:0000313|Proteomes:UP000193944};
RN [1] {ECO:0000313|EMBL:ORX85114.1, ECO:0000313|Proteomes:UP000193944}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S4 {ECO:0000313|EMBL:ORX85114.1,
RC ECO:0000313|Proteomes:UP000193944};
RG DOE Joint Genome Institute;
RA Haitjema C.H., Gilmore S.P., Henske J.K., Solomon K.V., De Groot R.,
RA Kuo A., Mondo S.J., Salamov A.A., Labutti K., Zhao Z., Chiniquy J.,
RA Barry K., Brewer H.M., Purvine S.O., Wright A.T., Boxma B., Van Alen T.,
RA Hackstein J.H., Baker S.E., Grigoriev I.V., O'Malley M.A.;
RT "A Parts List for Fungal Cellulosomes Revealed by Comparative Genomics.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ORX85114.1, ECO:0000313|Proteomes:UP000193944}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S4 {ECO:0000313|EMBL:ORX85114.1,
RC ECO:0000313|Proteomes:UP000193944};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORX85114.1}.
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DR EMBL; MCFG01000040; ORX85114.1; -; Genomic_DNA.
DR STRING; 1754192.A0A1Y1XIC6; -.
DR OrthoDB; 1067095at2759; -.
DR Proteomes; UP000193944; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18577; ABC_6TM_Pgp_ABCB1_D1_like; 1.
DR CDD; cd18578; ABC_6TM_Pgp_ABCB1_D2_like; 1.
DR CDD; cd03249; ABC_MTABC3_MDL1_MDL2; 2.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR PANTHER; PTHR24221:SF503; LP14331P; 1.
DR Pfam; PF00664; ABC_membrane; 3.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000193944};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 125..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 748..772
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 792..822
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 887..905
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 911..928
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 990..1012
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..368
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 402..638
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 753..1054
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1092..1331
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 644..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1348 AA; 149231 MW; 09C58031A4097EFE CRC64;
MGNIKKKEEN DVPKVSYIGL FRYSNIIEKI MVALGILGAI GQGVTMPIMI QVMGDLINIF
ISLVITVGIK KNNPEIQNDE QLKEFFTNAI NNNSTGGYGA QYGSDYDYNS LLITSEEFWN
KFHKYMLYFG LVALLSFVGS FCMDAFLSIS ALRQVTRIRS LTFKSIVRQE IPWHEKTSPG
ELASRIISDT IIIEDGIGFK LGTVLQSFVT FISCFILAFI SGWKLALSMS VIFPILMIAV
ATMAIILSKC TKKSQDAYAK LGGIAQEAFS QIRTIVSFGT EQKEIDRYIS NLKPTRTLGI
IKGHTVGATL GVLFGVIYAS FCIAFIYGTH LIKDKEMIYG DVLNVFMGVM MGALMLTGVG
VNFSAFSEAT GAATILFDII DREPQVKLEG GLIPEKPTEG TIEFQDVHFN YPSRPDVEVL
KGISFKCLPG QTVALVGASG SGKSTIVQLM ERFYNKKSGN ILIDGKNIED YNVLWLRSQI
GLVSQEPTLF DSTIAKNISI NSPNATQEQI EEAAKLANAH EFIKKLSDGY ETSTGERGLQ
LSGGQKQRIC IARALMNNPK ILLLDEATSA LDNKSEKIVQ AALESAASGR TTLVIAHRLS
TVKNADLIIV MDKGVIIESG KHEELMNLGQ YYYNLVKNQE IKVKEEEEKE KEQEQNSDNE
NNDSSLPGQQ QTQFIEGVIN NRRESTSNNN INRILSTTSL NHRFTTGGFS DASSIMINGS
TNNIGKGFTF NLRDMPWRRY AKFNKPYWLP NTLGFIGALF NGVMQPAFAF IFSSALNTFT
KSGDKLIEGG RFWGIMFIFL GLCNFISFYF YIGGFIIAAE YLSYDLRKQM YNNMIRQEVG
YFDTNKIGDG SEEAGSQGPH GSPNSTGTLT AKLATEAGLV NGLNTNIGQV FQQVVTVVGG
FIIAFCNGWK LTLILLCAVP FLFLGSILKA KSTQTRTREN RAIFEGSSKI ACEAIVNIKT
VYALNLSEYF IKLYDSKLIE PKKRIERRSY ISGIGTGFSN AISFFAYILG YWVGAKFIEN
GSMDFDSMFK VLMAIILCSM AVGSTGDIIS ETQKSGEAFM HVLEIIDRKP KIDASDPKGI
KRENGEDFNA NLEFSEIRFR YPSRPKITVL RMGDKKITVP AGKICAFVGG SGSGKSTILG
LLPRWYDPNH GSVKVDNLEN KEYNIQWLRK QIGIVNQEPC LFNISIKENI KYGKLEATDE
EIYEACKKAN IHDFIMSLPE KYDTCVGGLG TSQMSGGQKQ RIAIARAIIR NPKILLLDEA
TSALDAESEL IVQKALEDAS QGRTTITIAH RLSTIKDADL ICVFKDGRII EMGNHMELME
KKGEYYNMVI AGDSSISKGN DIAKNSED
//
