ID A0A1Y1YN89_9FUNG Unreviewed; 495 AA.
AC A0A1Y1YN89;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=HD phosphohydrolase domain-containing protein {ECO:0000313|EMBL:ORX99448.1};
GN ORFNames=K493DRAFT_348566 {ECO:0000313|EMBL:ORX99448.1};
OS Basidiobolus meristosporus CBS 931.73.
OC Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota;
OC Entomophthoromycotina; Basidiobolomycetes; Basidiobolales; Basidiobolaceae;
OC Basidiobolus.
OX NCBI_TaxID=1314790 {ECO:0000313|EMBL:ORX99448.1, ECO:0000313|Proteomes:UP000193498};
RN [1] {ECO:0000313|EMBL:ORX99448.1, ECO:0000313|Proteomes:UP000193498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 931.73 {ECO:0000313|EMBL:ORX99448.1,
RC ECO:0000313|Proteomes:UP000193498};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-
CC deoxyribonucleoside + H(+) + triphosphate; Xref=Rhea:RHEA:46148,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18036,
CC ChEBI:CHEBI:18274, ChEBI:CHEBI:61560;
CC Evidence={ECO:0000256|ARBA:ARBA00001432};
CC -!- SIMILARITY: Belongs to the SAMHD1 family.
CC {ECO:0000256|ARBA:ARBA00005776}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORX99448.1}.
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DR EMBL; MCFE01000097; ORX99448.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y1YN89; -.
DR STRING; 1314790.A0A1Y1YN89; -.
DR InParanoid; A0A1Y1YN89; -.
DR OrthoDB; 5474479at2759; -.
DR Proteomes; UP000193498; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 3.30.70.2760; -; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR PANTHER; PTHR11373; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE; 1.
DR PANTHER; PTHR11373:SF4; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1; 1.
DR Pfam; PF01966; HD; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:ORX99448.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000193498}.
FT DOMAIN 55..190
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT REGION 454..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 57884 MW; 7E4A8317059BB02F CRC64;
MDTRLTKYVN DPIHGYINID EHCLDVIDTE QFQRLRDLKQ LGSAYFVFPG ASHNRFEHSI
GVSHLAGNLI ERLKVSQPEL EIDEQDIKCV KLAGLCHDLG HGPFSHIFDN EFIPRARPDV
IWSHEQASEM MLENLIEENY IDIDKQEIDF IKDLITGESR SVSQQHEKRF LFDIVANKRN
SVDVDKFDYI ERDCYNLGIK SSYDSSRLMT FSRVIDNQIC FHQKEVYNLY EMFHTRYSLF
KRIYTHRVGK SIEYMLTDAM LAADPYLEIS KAIDSPQDYL YLTDDILKHI ERSKTDELLP
ARKIIKRIRQ RQLYKFVDEF IIPSELKQYL TKSMVNEEEI VAQQKAGDNI SINDVIVEWL
SINYGKKNQN PVDSIKFFSR FNGNEAFSIP KTKVSYLVPE HFEEIVIRIF ARDVTKVQQI
QVAFRKLLKN FTSQIPESPD INLEPNYAHT YPNNFKSPSK RRYEQPPSFS SSPSKLCDNG
DIHCKSGKIR LEFSD
//
