ID A0A1Y1YRJ8_9PLEO Unreviewed; 644 AA.
AC A0A1Y1YRJ8;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 13-SEP-2023, entry version 22.
DE SubName: Full=Methylenetetrahydrofolate reductase-domain-containing protein {ECO:0000313|EMBL:ORY00653.1};
GN ORFNames=BCR34DRAFT_606174 {ECO:0000313|EMBL:ORY00653.1};
OS Clohesyomyces aquaticus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Lindgomycetaceae; Clohesyomyces.
OX NCBI_TaxID=1231657 {ECO:0000313|EMBL:ORY00653.1, ECO:0000313|Proteomes:UP000193144};
RN [1] {ECO:0000313|EMBL:ORY00653.1, ECO:0000313|Proteomes:UP000193144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 115471 {ECO:0000313|EMBL:ORY00653.1,
RC ECO:0000313|Proteomes:UP000193144};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY00653.1}.
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DR EMBL; MCFA01000180; ORY00653.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y1YRJ8; -.
DR STRING; 1231657.A0A1Y1YRJ8; -.
DR OrthoDB; 1381745at2759; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000193144; Unassembled WGS sequence.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR004621; Fadh2_euk.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR NCBIfam; TIGR00677; fadh2_euk; 1.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000193144}.
SQ SEQUENCE 644 AA; 72745 MW; F2BD71968612945E CRC64;
MHISQKLAQS RAEGKVTFSF EFFPPKTAQG VQNLYDRMDR MHGFGPQFID VTWGAGGHLS
HLTVEMVKVA QSAYGLETCM HLTCTDMEKS KIDDALRDAY QAGCTNILAL RGDPPRQKEK
WEATKGGFHY AKDLVRYIRE RYGNHFDIGV AGYSEGCEDN DDVDVLIDHL KEKVDAGATF
IVTQMFYDTD LFLDWVGKVR AKGIDIPIIP GIMPIHTYAA FMRRANWTKC NIPPHWTKAL
EPVKNDDVEV REVGKDLVAE MCRKLVDAGI LHLHFYTMNL AQATRMVLEE LELLPDLESP
LEKPLPWRPS LALNRRDENV RPIFWRNRNR SYVARTQDWD EFPNGRWGDA RSPAFGELDA
YGIGLKGTNE QNIKLWGSPT SIQDISDLFV RYMGGKLDSL PWSEAPISKE ADTIKNDLID
LNRRGFLTIN SQPAVNGAKS YDPIYGWGPR NGYVYQKAYL EILISPEFIA EVITRIERDP
DLTYYAVNKE GDLKTNSPGD GPNAVTWGVF PGKEIVQPTI VETVSFLAWK DEFYRLGQEW
ANCHSSVSPS RYVIEDVVDT WYLVNIVHND FHVEHGIFPL FDGLKVKDME KPLHSNGVIN
GHSERNGEPD QKVQNGINEK SIVDDIKSAA SAITNGLSGL TVAN
//
