ID A0A1Y1YX99_9PLEO Unreviewed; 1648 AA.
AC A0A1Y1YX99;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
DE AltName: Full=Mediator complex subunit 13 {ECO:0000256|ARBA:ARBA00032008, ECO:0000256|RuleBase:RU364134};
GN ORFNames=BCR34DRAFT_545633 {ECO:0000313|EMBL:ORY02683.1};
OS Clohesyomyces aquaticus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Lindgomycetaceae; Clohesyomyces.
OX NCBI_TaxID=1231657 {ECO:0000313|EMBL:ORY02683.1, ECO:0000313|Proteomes:UP000193144};
RN [1] {ECO:0000313|EMBL:ORY02683.1, ECO:0000313|Proteomes:UP000193144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 115471 {ECO:0000313|EMBL:ORY02683.1,
RC ECO:0000313|Proteomes:UP000193144};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex.
CC {ECO:0000256|ARBA:ARBA00025661, ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY02683.1}.
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DR EMBL; MCFA01000155; ORY02683.1; -; Genomic_DNA.
DR STRING; 1231657.A0A1Y1YX99; -.
DR OrthoDB; 9289at2759; -.
DR Proteomes; UP000193144; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF11597; Med13_N; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000193144};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 1..375
FT /note="Mediator complex subunit Med13 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11597"
FT DOMAIN 1074..1254
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1269..1630
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 113..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 793..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 902..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1406..1467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1545..1585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..589
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..664
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1409..1442
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1566..1585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1648 AA; 178444 MW; AC755BE716405060 CRC64;
MEFIKTCNTN AQAIGDFEAV AFQAFSVKRN PTAAASLGDR SPAEDLHAAE AEFRQGQHLV
VQDASKSLLW FFRATTADKA GQKPLALPLL KGYDFQAEQS GVMKASELAR PPMRNFTFNT
PSSTSSSSPS TPGGLKGPGF SSGNVRAAQG TSQSATPLDQ HQQHDSYAIY ELFTSSVVAL
ISYYLVRDHN ATALNYRTFL SKPSVQPDSD EDPPTSHSAN VPYCLTNLSV YWTSSGTLVV
SVSSVPRPEI RRLSEVESEE AQRDWMGRCV RVAPNGLLAK IVGFESPSEI GVEPLAHRSQ
RKRVKIGPVE QSIERWKTLV RRWLKWKGYS IADLDDKSSW VKLRMAHLSQ VPPASPAPSS
PSREVLWPRM LCLFYEELQS TRDGVDVARA PQKERTLEWF ETPDSTGFRD PLDVAQQWFM
GKSERDQAFE ALRKAQKAEE EAAQPKGDNH GLFPSSPLNS RTGAYGDLQA VSGVYPTPPD
GVAPGVGLPS SDNSAPPGSG TNTILVPGGS HPAINLSGPQ DHPSTDAHQH PAASPENPLP
FDQFNSNING GNDDLFEDLD EDAFGPGNDI TDADFSFFDE PDDENVDVDM PDAAAMQDSK
PPSQGKPAKE NEPSQLPEAD IKEELPDPMA ALDDALASAL HPPNEIDPVV KSEQRAEEPR
ATEQPPTEKL TSQLTQSDQS SIVAVKYEPS PPLSPRLVQK KLLPSPTDRS VFQTPKHRDS
IFDPVSFNRK MSLSDAKYHG GRFSFSIEKP TKIEEPKTVA KRPASLRDLP MLTKLRHAIG
MASARATEVK ALERADSDIS DSSSETSASE EEDPDDVESI GPATILHGIV IPGKRKLPTD
GNATPLSTTS FADSFAGDSL EVTGLQTDES CLMWFESNPA DWSLTYLPAP AGLPSTLARN
DIPTFSPISP SLPDTPTSQP DTPNDLPDEK PLGIKDSIAV AQIITDQIVS ATLDILHEGS
SPLALSAAER TPCETTVTTV VRKIFPKATD CNVLGLASVQ DVFPDLPQQS KGQPRSAPRK
INAQADGSAS PGHLIYQINS PHIRVRRGDT LWDVLPPALS FWEPLGLAPC NPAKNVVPFC
LYPHSHSLTP CLENFLVNIQ IAYETCKFGT HARIQTVPEY EGGLVPCRIN GHPSTRAAFK
VLRETCIQLG KLLAARHAQM REKDDTKVNA FVIYMIDPFD DASALWELCS AFWSLFQAYG
QVPSTRPGND VPPKPDLVLQ VVPIKCIASF DVPVILGSST YVNLAREVYD RCPPSTPSED
KTPLAIYTAP SFQLEESIPR TIPFKLNAEP PQDLLRESSY MHLGYAISLD GTWITVAWTD
SCGKSQAVVS YNLGTRSFGE VAKEIWQTTI EILQARRVTW RICIAKSGVM EREELETWVF
LASYPTQLNL FITLLTVDTN PPLKFTPAIP SPTAQSTSGT TTQHLSANTP SSTPQTGGVS
PDQHGLTPAA TPAEPPNDPS SDPDARLVNV TDESWGIILS HRLHNSNSTV DFRPCLISGL
LVKRGESYST SNTTSSAQLP DPERGPIVVG INILWVGAVG STRAAASPFP PSASGAEGVS
PGVVGASTTG GGQERSSTSL TWTPTAQSRA TAENLLKEIL GQFRALGLLA RLKGMRGTRG
GTVPWHVVAA KRGVGGLVEA LKEKEKDG
//
