ID A0A1Y1Z1N6_9FUNG Unreviewed; 2600 AA.
AC A0A1Y1Z1N6;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=K493DRAFT_311429 {ECO:0000313|EMBL:ORY04201.1};
OS Basidiobolus meristosporus CBS 931.73.
OC Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota;
OC Entomophthoromycotina; Basidiobolomycetes; Basidiobolales; Basidiobolaceae;
OC Basidiobolus.
OX NCBI_TaxID=1314790 {ECO:0000313|EMBL:ORY04201.1, ECO:0000313|Proteomes:UP000193498};
RN [1] {ECO:0000313|EMBL:ORY04201.1, ECO:0000313|Proteomes:UP000193498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 931.73 {ECO:0000313|EMBL:ORY04201.1,
RC ECO:0000313|Proteomes:UP000193498};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY04201.1}.
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DR EMBL; MCFE01000037; ORY04201.1; -; Genomic_DNA.
DR STRING; 1314790.A0A1Y1Z1N6; -.
DR InParanoid; A0A1Y1Z1N6; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000193498; Unassembled WGS sequence.
DR CDD; cd05392; RasGAP_Neurofibromin_like; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000193498}.
FT DOMAIN 1228..1420
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1592..1722
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 37..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2600 AA; 293853 MW; 3CF9B40FB51AF0A6 CRC64;
MLMSEDPPPV ELLQSQLFVL RVLGACMGHH WKCYRDQNST SKESEQSSQE DSSRPKCDSP
ETFTRRTSNN PYDSTSDLTS FSRHTSSIGS FETNLPTFLS TESLEDPPPL EEPLAKYILS
IVFRFLQQSY FVDSGDIYGQ SNKPTFSNFS MGSMAATTPS PSSALHSSIS RVYTELMKGI
HHAAGHILFY ISASNWPIVY QRIKSRMAIL TSTSDENADT SELKLLEWCN LNSRRLSTIL
QELCVVFLQF KRPAQMEMAI ILRKAIWSFI EVYPMDFIAL CQSEKRLEGG PEILFDVCNS
LADSNKRKMI LWPLQVMLLT LCPDILMVVA LSDEGANKKA QFYDNLRKSL RSSRLAEVAA
FSFVDLCKAS TYVSKVENAA LKLLVPEIES ELREKLFDPQ KPFLNYDDII DQKLMTDCLT
ALFRLNPEHA LKSLIPICLQ ANAPIAFRLV LVKTCYTIAS ESHLPWNPSI STMYSTIASP
LRQLFQENIA RDKPDIKKSL DRKSRRSQLE EANDRFEIVL NLLKLYRTDP MLAIVNENTS
TRCEENRLLL IGITNFLQET NVSIRTTAAE ALLELHQCTY IEQWCPSSMM KSFWIISSQV
MLTIAKQMLD YKERDEGIRF TLELIHQLLI RRNEFLRQHQ DLATEGADTM DRVNASIWLE
VALLISLCSP ETEICSLALK CLGHLCVEAD ITEENEDPQH SLLTIVENHE VYRELSSEGT
FVTGRVAQQK RIRRMLRQIV NRTDGNLAAC EEAYRRWRML MQNIARPPDD AQPEQPDTRR
RVAGVFYEKL TNATKSIVSV PQTEPVEDRG EWQNYTGFLC ALGGVCLRSS AAKRNEHDAS
VFPSPHTLHR SSSENRRILE TSKMINRFIQ EMVEWLVCDN VIVREGIKEI LGAELSPALH
AILFKQLESI VVVFFDAEGE AICKDTYTLF VEQAISVVRL ILDRLQEPSE QFYSIDIGNL
ILSFARYLNR LGFGHVALRI KIKMCQMCEI LMSKKDYISL RQEIKFRNRM LETVVEWTSD
YSMKSSDNQM TLEEQIIFHK NEKLHRDLDQ ACMKTIVVLL FQLPLQPSEP LQHDADLRQS
KSRLFYKYFS FFIKLLNRCR ILEVIPEKAI DNGRAKNNPD LQSLLSKSKE YCKDLGPLKD
YTILALSNLL SANIDSGLKY SLSMGYHDDP KTRTAFMQVL TNILNQGTEF EGLAESSMTD
RYDKLVELIT DDDLVIALSL CEVCPVPDID ELASVLLAIF DTRGNTMKLM KAVIERELMK
TESSSELFRR NCMATRLLAA FAKMYGSEYL RSTLQPILRE MVSNNHLAYE LDPTKMSMNS
DAAKNLANLK QMSQAFLDVI VASAPKVPRA FREICHFLST IVGERFPEAK SAAVGGFIFL
RFFCPAIVAP ETHNLVASFD NKEIRRGLLL ITKVIQNLAN NVLFGTKESF MITLNDFLTS
NIHKVSNFLL DISVAPSDSD TESIITTNSR LEDTDLSRLH RHVFDNLERI GRDLSTRKQS
KPFLIAPNTG LVANGSVNSD LEKPQSTSKK AHEKLSTVLA QLGPPPDVPR VERSSFDSKI
GASNEMFREF MQRNGYRNTE PIKSKRLFYE GGLSKERRPV LYLILRRVIA DAIDMELLIL
HILQTMESVM GKPYELLVDI TQFGHANEIQ NQWINQFLQI LPSDAVQNLA ALYMYNVNSA
FKKFSKKLGR PLTTKIGKKT IFPSNLNDLY DYIPLQELRL PKGTIALETD PGLIFSPVTK
IPHFRQPMPT IIKITNETVQ VTSLRKQDIF GLNSYFNDVY HVSDIDDVAL VTTRNDENNL
VIKYDRGNSS MTFASPKVDL IFKAIRNSKA RFQLSKPVNV SERIIRPNDV PGTLLNMALL
NSGSEDPNLR SAAYNLLYAL SLTFNFNVGN QLLSAQGLCI PSNNSSFIVS ISEMLAASEP
HLTLEFLSEC FVGFNKSTPS LKHLCLEYMA PWLSNLAEFS RNDGDNQHNL AKTKEIIKVF
IDMTVKEVEI TPAIQAKIWR TIGKVDEIIT PVLDAFVQYA VEHGIGSPQA ELMAETAVTL
SSVNVRGKLI SRLRKVISST SNKPMRTLTD HSSWVEIAVL IRFNLMLSFN NRLHVQHYLP
ELFHIVSMLV SIGPPIIRSS IHGLVVNIVQ SLCTSLPLEE ANLKKLNHLL GEFSEPKFRL
LFGLNRMIGN AFARLPDAVP DMPESVPLTS LETIVHSLLE VIELGAVSTD VANIWRARWM
SLVTSTAFNF NPAVQPRAFI VLGCLAKDEV DDDLLYQILV ALRGSLALFD ESDCNLIVSI
VTCLTNIVEN LPHNSRYLQQ MFWLGAALVQ IGHLPLFHSA LNLMEVVVRS LDTNGFFADE
TPDSFLMKAR EPLEDIAIEL DKATGIQFRT NFSFALAATL LKGLKQPSTK TATSNVLKSF
LEIFNKGNAD KQRVNPNLLG YIAPLLPTAA KNGELRELLW TVGIYDLEID NTVLSHTYFK
LLDRFVIPDD TTAILLVSLM VTMLNNAEYE AEFLFLYSFL AEAAVALPDV FSLVYDNLQT
KMNQILNSSQ NVPIIEAVHS ILYTMVSRPR DTTKRRNQNA ILSELGFSGL VDCGSFQALS
VGQMIRNAEL ASSMVEKIVG
//
