ID A0A1Y1ZFF6_9PLEO Unreviewed; 1241 AA.
AC A0A1Y1ZFF6;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 22-FEB-2023, entry version 22.
DE SubName: Full=Ras guanine-nucleotide exchange protein-like protein {ECO:0000313|EMBL:ORY08939.1};
GN ORFNames=BCR34DRAFT_603218 {ECO:0000313|EMBL:ORY08939.1};
OS Clohesyomyces aquaticus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Lindgomycetaceae; Clohesyomyces.
OX NCBI_TaxID=1231657 {ECO:0000313|EMBL:ORY08939.1, ECO:0000313|Proteomes:UP000193144};
RN [1] {ECO:0000313|EMBL:ORY08939.1, ECO:0000313|Proteomes:UP000193144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 115471 {ECO:0000313|EMBL:ORY08939.1,
RC ECO:0000313|Proteomes:UP000193144};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY08939.1}.
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DR EMBL; MCFA01000093; ORY08939.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y1ZFF6; -.
DR STRING; 1231657.A0A1Y1ZFF6; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000193144; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF354; GUANINE-NUCLEOTIDE EXCHANGE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06570)-RELATED; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000193144};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 82..152
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 767..887
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 948..1193
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1241 AA; 136294 MW; 2051097A59E52BFE CRC64;
MTEYMLEDDD VGKRQSALVA PLNIQKSPKR SRSRGPTHSR QSSSRGAPSV SSQSQSQSQI
SPPLTPRTSR DTFTAQIPAQ PVFHNYLRAF YHFHPSSTVS SSTDQSSITV PINQGDVILV
HSVHPNGWAD GTLLASGARG WLPTNYCEAY DHPTIRSLLN ALTHLWDLVR DGENGDLVTF
TKQDYVRGMI AGVRFFLERT QCLTRESPLI QSHVGLRRMR KGLLGDLSSL VKTAKKLQDI
LQIHDSPVPV FEQLDELVLK SFKLVTRAVR FLDIWAQDAV SAPFDFAEAG NNRPLTPPSD
AADPSVQPPA PSNQNDEDSA STNDYAASVS QASTTATRDE VDSPKDHQPR SLNRASVAFS
LPESDSLQSP LLPTQPQSQA KRLSVTHRLS YTGKSQGLRK QNLASERLNA AHDAFLGFIG
SFIGLHLQSR SSEELTLTTQ QSVVACRQLL AVVEAVWERD SRRSEPLAQA RDMMYGRLTD
LVQATKDMFS TSESGAGEVV VMPDSGKQLV AAATSCVRSA GDCVTKARSV IERIGDFEFE
NAAGLGLSET IFEKIGQDAE QEVVEVPSHP EPSAIETDKP LPAPPTAARQ APPPLIISES
KPLPDVPLST PLENPRLSLQ PIHHPAIVES PTAVSFRSSR SSLPPLNQLP TPHLPQPSPS
EYSQSPASAT QRFFSKSVRT DSVNASVADS SSTYRNSIRG DTGSIISQAS TRATTPDQSP
AKKENSAAIE SSFGSASELR SLASEDVAAV EEHLLETTYA HELIFNKEGQ ISGGSLPALV
EQLTTHESTP DAMFVTAFYL TFRLFTTPTD FAQCLIDRYD YVGNSQAVGV PVRLRVYNVF
KGWLESHWLP DSDAPALDII LSFATGKLRL TLPAAGKRLA ELTSKVTEVR AGALVPRLVS
ALGKTGISNT NFSPTDTNVP SPIITKSQLN ALRASKEGKS QCSILDFDPM ELARQLTIIE
SKLYCSIRPE ELLASEWTKK NGSRALNVRA MSTLSTDLAN LVADTILLLE DAKKRAVIIK
QWVKISIKCL ELNNYDSLMA IICSLNSSMV LRLKKTWELV SAKTKARLEE LKTITDVGRN
YAVLRQRLQD HVAPCIPFVG IYLTDLTFVD VGNGTTRQLP GEEGRESVSV INFDKHMKTA
KIIGQLQSFQ VPYRLAAVPE MQDWMDAQIQ RVRTSDQANV QSYYRRSLIL EPRDPPQLVK
ASPPLIENAL EKTLTAESRT NSKDRFEFLN FHFSSTIKDR Q
//