ID   A0A1Y2A0N8_9PLEO        Unreviewed;       544 AA.
AC   A0A1Y2A0N8;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN   ORFNames=BCR34DRAFT_558673 {ECO:0000313|EMBL:ORY15605.1};
OS   Clohesyomyces aquaticus.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Lindgomycetaceae; Clohesyomyces.
OX   NCBI_TaxID=1231657 {ECO:0000313|EMBL:ORY15605.1, ECO:0000313|Proteomes:UP000193144};
RN   [1] {ECO:0000313|EMBL:ORY15605.1, ECO:0000313|Proteomes:UP000193144}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 115471 {ECO:0000313|EMBL:ORY15605.1,
RC   ECO:0000313|Proteomes:UP000193144};
RG   DOE Joint Genome Institute;
RA   Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA   Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA   Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA   Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA   Visel A., Grigoriev I.V.;
RT   "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable lipid hydrolase. {ECO:0000256|ARBA:ARBA00002682}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ORY15605.1}.
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DR   EMBL; MCFA01000024; ORY15605.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y2A0N8; -.
DR   STRING; 1231657.A0A1Y2A0N8; -.
DR   OrthoDB; 154387at2759; -.
DR   Proteomes; UP000193144; Unassembled WGS sequence.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006641; P:triglyceride metabolic process; IEA:UniProt.
DR   CDD; cd07229; Pat_TGL3_like; 1.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR002641; PNPLA_dom.
DR   InterPro; IPR021771; Triacylglycerol_lipase_N.
DR   PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR   PANTHER; PTHR14226:SF44; TRIACYLGLYCEROL LIPASE 3; 1.
DR   Pfam; PF11815; DUF3336; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000193144}.
FT   DOMAIN          137..344
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
FT   REGION          515..544
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   544 AA;  60933 MW;  75AD1ACD96386306 CRC64;
     MIGADNLVML QRLYAWWTKK SARDVLLECT ADARIFEEWE ASAFQLDEVL GYDLWRQNPT
     SKYYDYRLIY ERLQAIIEAR EEDDILGLVS LLRSGLVRNL GNITAPRLFN RAYAGTKLLI
     EDYVTQVALA IDYVTSYPTK ASSDTGLTNQ AKLDVLHDTR QAFGRSVLVL QGGAIFGLLP
     RIISGTATGA LIAALVGVHT EDELLDFLTG SNIDLTAFAK RSVNGKEGQG SGQSGWFATL
     KRRVQRFVRE GYFLDVGVLE QVVRANVEDL TFEEAYGKTK RVLNITVSTT GGGGVPNLLN
     YLTAPNVLIW SAALASNASS STLYHPVTLM CKDESGKIVP WTSAEETTFR PWTHASYADR
     ESPLHRIAEL FNVNHFIVSQ ARPYLAPFLR SELHHPNPRQ DGRWGLSMPI LRLIVMEIQH
     RLHQLDEVGW LPSSIRRFLL DENVPGASLT LVPELTPGDF FKLLENPTKE SLEYWILRGE
     RSVWPAVGAL KVRCAIEVEL DRGYQLVRRR KPFDPVHGPG LKKSSSTVSR KRARAASFGG
     DVMR
//