ID   A0A1Y2A1Z4_9PLEO        Unreviewed;       860 AA.
AC   A0A1Y2A1Z4;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Nonsense-mediated mRNA decay factor {ECO:0000256|RuleBase:RU369098};
GN   ORFNames=BCR34DRAFT_107652 {ECO:0000313|EMBL:ORY16488.1};
OS   Clohesyomyces aquaticus.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Lindgomycetaceae; Clohesyomyces.
OX   NCBI_TaxID=1231657 {ECO:0000313|EMBL:ORY16488.1, ECO:0000313|Proteomes:UP000193144};
RN   [1] {ECO:0000313|EMBL:ORY16488.1, ECO:0000313|Proteomes:UP000193144}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 115471 {ECO:0000313|EMBL:ORY16488.1,
RC   ECO:0000313|Proteomes:UP000193144};
RG   DOE Joint Genome Institute;
RA   Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA   Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA   Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA   Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA   Visel A., Grigoriev I.V.;
RT   "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in nonsense-mediated mRNA decay.
CC       {ECO:0000256|RuleBase:RU369098}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369098}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ORY16488.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; MCFA01000018; ORY16488.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y2A1Z4; -.
DR   STRING; 1231657.A0A1Y2A1Z4; -.
DR   OrthoDB; 1356823at2759; -.
DR   Proteomes; UP000193144; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR018834; DNA/RNA-bd_Est1-type.
DR   InterPro; IPR019458; Est1-like_N.
DR   InterPro; IPR045153; Est1/Ebs1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR15696:SF0; PINC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR15696; SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7; 1.
DR   Pfam; PF10374; EST1; 1.
DR   Pfam; PF10373; EST1_DNA_bind; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
PE   4: Predicted;
KW   Nonsense-mediated mRNA decay {ECO:0000256|RuleBase:RU369098};
KW   Nucleus {ECO:0000256|RuleBase:RU369098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000193144}.
FT   DOMAIN          59..172
FT                   /note="Telomerase activating protein Est1-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF10374"
FT   DOMAIN          184..490
FT                   /note="DNA/RNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF10373"
FT   REGION          626..649
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          680..798
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          840..860
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        703..743
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        757..795
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   860 AA;  94811 MW;  934DA0BAE1994AA3 CRC64;
     MATNTDPLAR RAQSTETNLS KLLDSDGPAA DLAAPLQEHR VACENLVFAD FEAAAAKGIE
     KQLWAAHLKV NGAFKKELKI NSKDHVVEHR KLAKHYLQFI KASQRFYRQY ILNLDAQFDR
     LPELRKVAQN WKDDVTKAPL RKRVPASLKK QILLSCHQTL IQLGDLSRYR ETELVDKDRN
     WGPATGYYGL AAEINPDSGQ SHNQLAVIAR EDGNHFRSTY HLYRSLASKE PHLLAKQNLE
     LGFKKIVTAW NRGELISNRT SPDGNTAGQA LVAWFIRLHS KCYRGKEFAQ HDELENEVLG
     QLAIELKERP LDSILHKIIL INLAAEYYAT VQMAGMEHSL KHLGSANSAD ATPPENITQT
     YFYYLRLNVK TFFTLLQILQ SELERYSEGA DVREQNGSRT RNLSDKITAV ARRILPGLRL
     YSTWFTRYHH VLSANIADTL TTVEVQELWK SYAATLTLLA SSFPPGELPK QDYMLEEDTD
     TIGFQPLISE ETMKRWYNGD VLKPKWSDVE RNHPNVEMLM RVRDLMMDGL LLIQNHPEAP
     LEIDNMRFIY REAGLPSELL ASPSNQLDRS PTMSTGPVDL PLFPAEVPVA EDQKTFSIAA
     ASESASTTLA KDSAMNQMVD DLVGPDEGLD PLPEEDENIP PTPPEQTFED TTLVTDTTYG
     IGPLTVSDFV NVVQNYSKPL GSPTTPMHAA SLGGAPMGGT PMGRVASSSS IRRPANLPSL
     PDGQSNGTSI WNRNYNGTPG PSSPLLGAGS AARGSPLNGV HASTASGHVR GDSSNSLRSS
     DWTTTPITTQ RPVSGGLGSG AVWGNPIVPN YGSIYGNSWN RPVTSTDANL TSQFLFAKDS
     SYPDGGHSSY GRTLPPGQGG
//