ID A0A1Y2A571_9PLEO Unreviewed; 2441 AA.
AC A0A1Y2A571;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=THO complex subunit 2 {ECO:0000256|ARBA:ARBA00019596};
GN ORFNames=BCR34DRAFT_23262 {ECO:0000313|EMBL:ORY17656.1};
OS Clohesyomyces aquaticus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Lindgomycetaceae; Clohesyomyces.
OX NCBI_TaxID=1231657 {ECO:0000313|EMBL:ORY17656.1, ECO:0000313|Proteomes:UP000193144};
RN [1] {ECO:0000313|EMBL:ORY17656.1, ECO:0000313|Proteomes:UP000193144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 115471 {ECO:0000313|EMBL:ORY17656.1,
RC ECO:0000313|Proteomes:UP000193144};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the THOC2 family.
CC {ECO:0000256|ARBA:ARBA00007857}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY17656.1}.
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DR EMBL; MCFA01000011; ORY17656.1; -; Genomic_DNA.
DR STRING; 1231657.A0A1Y2A571; -.
DR OrthoDB; 179356at2759; -.
DR Proteomes; UP000193144; Unassembled WGS sequence.
DR GO; GO:0000347; C:THO complex; IEA:InterPro.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR InterPro; IPR040007; Tho2.
DR InterPro; IPR021418; THO_THOC2_C.
DR InterPro; IPR021726; THO_THOC2_N.
DR InterPro; IPR032302; THOC2_N.
DR PANTHER; PTHR21597:SF0; THO COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR21597; THO2 PROTEIN; 1.
DR Pfam; PF11262; Tho2; 1.
DR Pfam; PF11732; Thoc2; 1.
DR Pfam; PF16134; THOC2_N; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000193144}.
FT DOMAIN 124..866
FT /note="THO complex subunit 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16134"
FT DOMAIN 870..945
FT /note="THO complex subunitTHOC2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11732"
FT DOMAIN 1229..1529
FT /note="THO complex subunitTHOC2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11262"
FT REGION 1..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1139..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1623..2441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..607
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..690
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1140..1161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1196..1211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1628..1651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1713..1807
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1822..1855
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1870..1898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1939..2009
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2018..2051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2085..2101
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2239..2269
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2278..2361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2385..2441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2441 AA; 270489 MW; 2B488740504ABE31 CRC64;
MAPGTKRKRG DRNYSYDSNE NSSRPSPHRP LQLGLAQTSQ QNSNGRGSSR RNSRQSGRGG
SSAPQSPTVA QTAPGAMSPP ATVPAQTKPT PPANPPSAQA SATTDEPMDQ SEQPPHPAAA
NIVLTLERVI TWKDGGRKAT MEAGIAFLSE CNMLMLAVLF EELLQACVDR LLPANELGST
VQDILAHPCS DALEPASIFL DTANTMMESG VQLNSIKPLL EASGVDPQKM RGELETTLLT
TLNMVRPTFP RVAIRKTTHA LYRQSNYNLL REETEGYSKL ITEYFTTVNN EPPKLEVVTD
TFERVKALIG AFDLDVGRVL DVTLDVFANL LVKHTKFFVK FLRASSWWPQ QEAPHGIEWE
EPAVSALPKW AQPNVTNWYY TEEEKDEQLR LREIRDREFW TRVPLSTKSR SDGIKAFFEL
GARRIVSGQS TLPPKAKSKE DAAFPADMPD FEKTEKWSQQ YMAETGALPP PGNRVAAQLL
GFKLRFYASD ARDVHDTLPD NLIHLAALLI KIGFISLADL YPHLYPLDED MEALKGKLEA
VRQAELDKIK AQSGNALTKA APLTDDTLPT PAPVARLREA DSKIPSKPES ERGTPARTED
DTKKNLPEPV DQKTALLRSL LLIGAIPDAL YILGLYPWLL TAYPDLQIYI IRLLHHSLSK
VYAWTRPAST QNIPTTPKHM PSTGTGAHAS SRPSDYPPRR TLRWAKLEER DAGDGIDYRF
YWEDWMDNVP ICQTVDDVFK LCDSLLGLVG PQIGKDPTLL TKLIRIGKKS LAEDASDNNI
ERWVILSATL LGPATSFTGA NPGVVNELWE FFRFFDTTQR FRIYKNWFTS RSATNNQKEM
MAKFLQIKAE TFPLLNRISK ENVKSLGKAF GKVAHASPGT VFQLAIERFE KYPNFVEVLV
ESCRFLTYLG YDCLTWALTN SLSQMDRDAA QADGMLTSPW LRNIAEFIGK VCRRYSNMDS
VPMLKYFLDQ MARGNVHIVV IVEQVVTSMA GIGSYVTLTE SQAMGISSGP RLRSFTLEHY
LGDQQHLSKA SAKRLMKCLK GSGLGPHILI ALAQEVFGYQ HRSECKNTPE KVIGLILDNL
LACFAQFLDL LRNNLTIDEF DSMVPGVVEL ISDYNVDPAL GFAICRASIA AHVNAARNEA
RSSPLKTKND QIQNQTNGDV TMGGVEGDVA IKANPPSHSV DVEMEDAPKV EESSTPKEAA
TPSPLSPRSN SNPVIEALAE QLKPALPDHV CLGFYVTFWE LSLRDIHCPM KEYQAATNYY
AEKSKAIDTR RDSVQLSKKR DAERALWLEE NKAILREVTQ FSQTCKHTLK QLQKEMHHWF
EGVPMVGTDL LYEKIIQDCF LPRIQLSSED AQFTSTMLKL MHSSGVPGFR TMKLLDTLFK
TSFLVKVLLM STSRESQNLG RFFHDVLQEL ATWHSSQDSY TKFATGEKKL PGFGRTFNAD
RTPATFLDFE DYRRVLYKWH SQFRQALETS LKSDDYMHIR NAINILKAVA PSFPVVDTMG
KSLHQLVQNM SRTEPREDLK LAAMSLLGDF KKGENKWVAA SSFHIVRAGA AVPTAGVRVA
SEHPNMPQPA DTPPKTLNAA VPAFTPKTVV VNGTSNAVTK TSNEHEDGEV DDEKNKTAIE
AAAATARGQP ATQHSTPVTS KPTISAPNKD TDSKPRNIRS DTNPSKPISS HGSLPVLIPT
RPDSRGPGSH ASPSVSASRV PHALPSKPDT RPSAVRPVDR PADHVPDHST HARHDVRSKA
TNDFGRLDRP AENSRESFPD RRELSPGRRP RGRTPDRGPN AMDRRDPGWG GRDLRDYHDE
RSMRPPPRDA RVPPPGRGAA WEDLSRDPRD TRDLREPRDP RGPRDPRDPR DRLDSRGPPL
APPLDNRARS HLSTPASVDD VNSYRRDTAP NTPQGGERNG QLPPRPSVER PATNVPAPAL
DRAPPATGRP LINPERAAFI EGDRGRNDGF RSERDTRRER SRPQSPRRPE ERTPASHHSR
NEPGRDSRDE RINEREMRSR DRREEPTGHA PTGPRGGRNE FTESQMSSRA TREMFQPSHG
SRGSQAQDPN YGRLKDNVDP PPSGPRSSMP DRRDQPRREQ AAYDQAQPPP PPPPPTGPAQ
PDTSGVHPSR LNHIRGPPIQ TDIPGAPSGP RGAARTPHGP GASPSTRTAP TGPASIERNG
RGQDKSFART LNSVFSQGAP AAPGGPAAVN DRGVADRGTS IRGRGSRASG PVEPPNLPSP
VGSHSHPGTP ITARPEGPPS RVDRPEHPLN KVDNHLPEDG RESRSSRDGR RGERRHRSRS
PDRGDRRPDE RSSRNDELGP GADRERGSGR EKRSGDSSRR DRERDGERSA RDGKERRERG
SERGGERGGR EDGRGSGRGE ETNPRRGPAS TLVGPPQWTG DVRPELRGGE PRGRNGGERR
GDDRDRRGGR EDGRDGRGRK RGGDDSTVHG GDMKRPRRSM N
//
