ID A0A1Y2A8A8_9FUNG Unreviewed; 1385 AA.
AC A0A1Y2A8A8;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=TBC-domain-containing protein {ECO:0000313|EMBL:ORY18275.1};
GN ORFNames=LY90DRAFT_677212 {ECO:0000313|EMBL:ORY18275.1};
OS Neocallimastix californiae.
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Neocallimastigomycetes; Neocallimastigales;
OC Neocallimastigaceae; Neocallimastix.
OX NCBI_TaxID=1754190 {ECO:0000313|EMBL:ORY18275.1, ECO:0000313|Proteomes:UP000193920};
RN [1] {ECO:0000313|EMBL:ORY18275.1, ECO:0000313|Proteomes:UP000193920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G1 {ECO:0000313|EMBL:ORY18275.1,
RC ECO:0000313|Proteomes:UP000193920};
RG DOE Joint Genome Institute;
RA Haitjema C.H., Gilmore S.P., Henske J.K., Solomon K.V., De Groot R.,
RA Kuo A., Mondo S.J., Salamov A.A., Labutti K., Zhao Z., Chiniquy J.,
RA Barry K., Brewer H.M., Purvine S.O., Wright A.T., Boxma B., Van Alen T.,
RA Hackstein J.H., Baker S.E., Grigoriev I.V., O'Malley M.A.;
RT "A Parts List for Fungal Cellulosomes Revealed by Comparative Genomics.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY18275.1}.
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DR EMBL; MCOG01000320; ORY18275.1; -; Genomic_DNA.
DR STRING; 1754190.A0A1Y2A8A8; -.
DR OrthoDB; 3034081at2759; -.
DR Proteomes; UP000193920; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR PANTHER; PTHR47219:SF19; RUN AND TBC1 DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF02893; GRAM; 2.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00568; GRAM; 2.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000193920}.
FT DOMAIN 702..889
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT DOMAIN 1221..1256
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 310..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1385 AA; 161638 MW; 62DA147159B698FC CRC64;
MFIKPVNIEL LNDNSKWIPK AANLYLTLES RDKPTKNVIS NIFSSIRQDK NEEKKTIYYY
DFRIILNFHS EGKEKYIVAV DETFEKIHDD WNKIEQSFLY KLNNNIINID VSENDNEIEF
YLLHQFNEIS KNTDNLLISQ EKKQLEEMKN KIKIFDKKLK DEVLLNFYSC LLSADDCNSF
VNGHMYITKN YLCFHNYITL SPNIRNNSEK WNMLLIAYKD IYSIDKKTIR RKLLSEECIE
ITTMNEMKYT FTMIRDIGNV IQIITALCDV AMRKLVRGAE LFSTTVLNEK VKIRSDLDLY
MAQLGITKYN NTNNNGNSNK NTNNSSINKD LSKNMSESDA SLKLDGILGN INNDSNSNNM
MMTEENARKN QNMARSVIPN RYPIHLESLL TTVSDLDNYK RNIEFLNLFH LPPTESINYL
LNSCTFYHKQ INDFISGTLF ITKHYLCFNN NDKKNDNFKP TVLVVLAFNQ ITSAKKLSRN
ISPNGILNIA YSGYLQIINR SKHEFWFSFA NVKLKDEIYD IIMERLKNVD WEFDNTNVGE
TFREIERNRH FIKDTSSVDT GSEVNESTPS RMQSLTSLLN NYNLLINNEE NSMKDQEVKG
SDTISSSMAP VGLKFIYEDD GTYRTAAIAS TVGSENKIVS PSVNIDIEDE KEKLRIIKND
FRQKEKINAE QLWKEYLKIN GNDMSMIRDI HFMRKLLLKC NGIPDIYRGD IWMITSGSWY
MKPDKNYYIS LLKDHIGEKS IYALEIEKDV RRSLPEHPAY QTKEGINALR RILTAYSWRN
QSIGYAQALN IIGATLLLYL KEDDAFWLLC NLIERILPDH YTRTLVGSVI DQTVFTHLVE
LYLPEIHKHM DDLYMDMSTI SVPWFVCLFL NSVSISVGIR ILDSFFLDGP KFIFWLGLAI
LKLNEKLLIE EGKDDERFIN IIKSFFHRLE VDEKDYYEEE NDEDQLDEAG STHFSRPLVG
NELYNHLLEI AYSYSNTVST ELIERLRSKY RLQVVHNMEA SNKRSQIRNI GETVSIPEES
ISIIYDKLQD LEYYENNEIK KNIFYPSYIK GWFSNDDDQC NYFYKLGGWG MNDSINETND
IYNNQYKNLD DLVLTTSIDL KNFRIIYNLI SPWKSKEYTP KSYNTLEEYD KHNINLLEDK
NNVNKDLSNI SIKSLHDDYS SPLSDRIYFY QTFKNVKTND ETFKNNKKGF IIKDRDISKY
LPCSIDLAGM IRIFEIIMLK SVNTKLEFLF DLHDTDGDGF LNEYEINDLM GTLFHIFSID
TRNNSSISLL EDHIENNEEN VQNDTKVLTV EPEDEFIQEE SFMKAISSFY NLAIKLGNSR
DENIAEQLVE DNSLTSNTKL SLNNFMVAML SQDAFVKYFE KSWTIKQVNL SNELVPVIVE
KEPTS
//
