ID A0A1Y2B0X5_9TREE Unreviewed; 881 AA.
AC A0A1Y2B0X5;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Protein HIR {ECO:0000256|RuleBase:RU364014};
GN ORFNames=BCR39DRAFT_535595 {ECO:0000313|EMBL:ORY28137.1};
OS Naematelia encephala.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Naemateliaceae; Naematelia.
OX NCBI_TaxID=71784 {ECO:0000313|EMBL:ORY28137.1, ECO:0000313|Proteomes:UP000193986};
RN [1] {ECO:0000313|EMBL:ORY28137.1, ECO:0000313|Proteomes:UP000193986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=68-887.2 {ECO:0000313|EMBL:ORY28137.1,
RC ECO:0000313|Proteomes:UP000193986};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY28137.1}.
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DR EMBL; MCFC01000033; ORY28137.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2B0X5; -.
DR STRING; 71784.A0A1Y2B0X5; -.
DR InParanoid; A0A1Y2B0X5; -.
DR OrthoDB; 5478541at2759; -.
DR Proteomes; UP000193986; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000193986};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 14..46
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 68..99
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 126..167
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 168..209
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 623..820
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 375..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 881 AA; 96071 MW; B59F76B79C3B7FF6 CRC64;
MRITRPNWVK HTDEKDKRSP IYSISVHPDG TRLASGGLDK KVKIWSTLPI LDLEAEENEA
NPKLLCTMSS HTGSVLSVRW AHHGRFLASG SDDMCVVIWG VDPEGGGRVF GSDEVNVENW
KALTRLVGHT ADIIDIAWSR DDSMLATVGL DKMVNIWDGA TFQRIRKLDQ HGDFVKGVTW
DPVGNYLATQ SDDKTVKIWD VTTWTLVHSV AAPFANSPKS TFFRRLSWSP DGAFIAASNA
MNGPVFVAAV IEREGWGSDI SFVGHENTIQ VAAFNPHLFL PPNAPHTRPN ASVLVALGAD
DYSISIWRNT KHKPLVVLQN LFERALLDLC WSNDGYSLYG SSADGTICAV HFTEAELPDI
APHNVTDEIL AEFDFKPPPR ATPRPLPAAP TASSTGFGPS VSSGGHVNVL QPRKAKPKPL
NGKKRIDLSG GGDSRASNGF GPPNNFQDAD AFSSAPIQPL ASPSAAQAST ARMFRDAHSA
FGNGTSDGDN VRAGHKRKAS LLVEGAERVP KNRTMGGSSV RTGEVSEIRA PRVPVAGPSG
QSGRFLPLPG VQNVVRTQFQ GSELEAQNAV QAGQRNKIVL RRDGQDQWID YVPCGITILS
VSDKFGAAAG ERGELFVYSS AGRHLATLKL DSPISEMTIK GGQLAVVTAK CLLRVFNMTK
LKSAVPPISI ESLLDAPVDS SGGTSNALDL TRLEVRPNGV PIVYTSEPCA FVYDTNLSSW
TPVASPWWIA HSQQSDRRSV SSGPLAEIEL YLSSSWTKPD DIGDRPQWFD EAVEMGHLES
RMKASILLDS KEEYRHWLMK YAGVLGREGF RERAEELIKD HVGPIYQHKK DLEWEDTLFG
APKRDWAKPL LATLASTTAL SGLANHWQQL LRNASAEENA W
//
