ID A0A1Y2BFF5_9FUNG Unreviewed; 494 AA.
AC A0A1Y2BFF5;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Creatinase/aminopeptidase {ECO:0000313|EMBL:ORY33549.1};
GN ORFNames=BCR33DRAFT_856206 {ECO:0000313|EMBL:ORY33549.1};
OS Rhizoclosmatium globosum.
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Chytridiomycetes; Chytridiales;
OC Chytriomycetaceae; Rhizoclosmatium.
OX NCBI_TaxID=329046 {ECO:0000313|EMBL:ORY33549.1, ECO:0000313|Proteomes:UP000193642};
RN [1] {ECO:0000313|EMBL:ORY33549.1, ECO:0000313|Proteomes:UP000193642}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEL800 {ECO:0000313|EMBL:ORY33549.1,
RC ECO:0000313|Proteomes:UP000193642};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY33549.1}.
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DR EMBL; MCGO01000067; ORY33549.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2BFF5; -.
DR STRING; 329046.A0A1Y2BFF5; -.
DR OrthoDB; 1377484at2759; -.
DR Proteomes; UP000193642; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 1.
DR InterPro; IPR007865; Aminopep_P_N.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000994; Pept_M24.
DR PANTHER; PTHR43226; XAA-PRO AMINOPEPTIDASE 3; 1.
DR PANTHER; PTHR43226:SF1; XAA-PRO DIPEPTIDASE; 1.
DR Pfam; PF05195; AMP_N; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:ORY33549.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000313|EMBL:ORY33549.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000193642};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 476..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..116
FT /note="Aminopeptidase P N-terminal"
FT /evidence="ECO:0000259|Pfam:PF05195"
FT DOMAIN 167..413
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
SQ SEQUENCE 494 AA; 55497 MW; 6E2AC9DF5E4340A3 CRC64;
MNPFDPFPLR SLAIDNRQRT LARLLPKAST GVVFITSSTR EFFYYLTGLT PLDSDHPFAL
LLELPSGRTT LFSPEYDDEF RLWNATPKTF DELRAEVGVD SVVAAGQLGG VLEKILGPVG
AGGIVHILDS TLEVIPDEVK RYNLKRKEFT HAITESRVFK STAEISLLRQ AAEITSKAHI
QLMKTASIYT YEKQLEAEYV YSISMSGARN ENCILSSARS RKPRINLVDS GVVLYGYVSD
VSRTFPRSGR FVGDWKLVYE AVLDAHKAVC QAMRPGVEWE DLHRLADRVM LGHLVKIGVC
NGDFEELVRN HVGALFFPHG VGHLIGLEGH DVGGYPDGVK PIDEPGIDKL RMRRKLEAGM
VVTVEPGLYF NSNLIQKAVK GGVLTEFLDL KRVKEIEEHV GGVRIEDMVL VTEEGCEVLS
KDVPKEVADI EKIMKGAMNE KGVMMNFMNP LKDVEEGVAT LKELWKQEYM NIARRIWTER
LILFLIFFCL YLTK
//
