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Database: UniProt
Entry: A0A1Y2BHF6_9TREE
LinkDB: A0A1Y2BHF6_9TREE
Original site: A0A1Y2BHF6_9TREE 
ID   A0A1Y2BHF6_9TREE        Unreviewed;      1056 AA.
AC   A0A1Y2BHF6;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   05-JUN-2019, entry version 11.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=BCR39DRAFT_516910 {ECO:0000313|EMBL:ORY34222.1};
OS   Naematelia encephala.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Tremellomycetes; Tremellales; Naemateliaceae; Naematelia.
OX   NCBI_TaxID=71784 {ECO:0000313|EMBL:ORY34222.1, ECO:0000313|Proteomes:UP000193986};
RN   [1] {ECO:0000313|EMBL:ORY34222.1, ECO:0000313|Proteomes:UP000193986}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=68-887.2 {ECO:0000313|EMBL:ORY34222.1,
RC   ECO:0000313|Proteomes:UP000193986};
RG   DOE Joint Genome Institute;
RA   Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA   Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA   Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A.,
RA   Culley D., Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E.,
RA   Spatafora J.W., Visel A., Grigoriev I.V.;
RT   "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ORY34222.1}.
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DR   EMBL; MCFC01000003; ORY34222.1; -; Genomic_DNA.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000193986; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000193986};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000193986};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN       89    429       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      493    924       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      961   1033       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION       35     56       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1Y2BHF6}.
SQ   SEQUENCE   1056 AA;  118912 MW;  21B3446D5D5050A5 CRC64;
     MVEPSNKKRK LEANGHTPLI KHESFSAVLA QLEAEEDASQ DHIESSSAWP RPSAPRINSH
     SDSIAFQQIE IEEALDPKFG PTLRLFGVTR QGNSVLAHVH GFRPYFYIAA PSGFLNKDLE
     PLKDTINSAV QSPVPPVVSC SIFNRRSLWG YRGDEVVPFI KILCTDPKSL PRVKGAFERG
     QIDFNSLFPP EVLTYESNIA YTLRFMIDTK VVGMNWVEVK GGRYELIEGK DKRSLCQLEV
     SLSYKDLISH APEGEWLNIA PLRILSFDIE CAGRKGIFPE PQIDPVIQIA AMVSRQGEKK
     PFVRNVFTLN TCAHIVGSQV LEFQDERALL LEWRKFVEKV DPDMIIGYNI SNFDLPYLLD
     RAKALKIPDF AFLGRMCGVK TEVTNTHFSS KAYGQRDSKA VNMEGRLQLD ILQVMQRDYK
     LRSYTLNAVC AQFLGEQKED VHHSIITELQ NGTADSRRRL AVYCLKDAYL PQRLMDKLMS
     FVNYTEMARV TGVPFNYLLS RGQQIKVISQ LYRSAGEAGY IIPALKSEGT DEQYEGATVI
     EPTKGFYDVP IATLDFASLY PSIMMAHNLC YTTLLDKQTI DRLKLVEGED YVHTPNNDYF
     ATAKRRKGLL PSVLENLLAA RKRAKADLKV EKDPFKRAVL DGRQLALKIS ANSVYGFTGA
     TVGKLPCLAI SSSTTAYGRQ MIEFTKKEVE AEYSVKNGYD HDAKVIYGDT DSVMVRFGCP
     DLPTAMRMGA EAADLVSAKF IKPIKLEFEK VYFPYLLISK KRYAGLYWTK PEKYDKMDTK
     GIETVRRDNC RLVSTVIETC LFKMLIDRDV KGAEDYVKQT IADLLQNKID MSQLVITKAL
     AKADYAAKQA HVELAERMRK RDAGSAPALG DRVAYVIIKG IKGAAAYEKS EDPLFVLEHN
     VPIDTRYYLE NQLSKPLMRI FEPILGEKAG SLLAGEHTRS IQIATPTIGG LMKFAVKTVT
     CLGCKTPLRS NKDGAVCVNC RPKLPELYQK QVAQTSMLQI DFARLWTQCQ RCQGSLHQDV
     ICTSADCPIY YRRTARQKEV AASVAQLDRF ENEQSW
//
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