ID   A0A1Y2BL91_9TREE        Unreviewed;      1483 AA.
AC   A0A1Y2BL91;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=VPS10 domain-containing protein {ECO:0000259|SMART:SM00602};
GN   ORFNames=BCR39DRAFT_567933 {ECO:0000313|EMBL:ORY35539.1};
OS   Naematelia encephala.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Naemateliaceae; Naematelia.
OX   NCBI_TaxID=71784 {ECO:0000313|EMBL:ORY35539.1, ECO:0000313|Proteomes:UP000193986};
RN   [1] {ECO:0000313|EMBL:ORY35539.1, ECO:0000313|Proteomes:UP000193986}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=68-887.2 {ECO:0000313|EMBL:ORY35539.1,
RC   ECO:0000313|Proteomes:UP000193986};
RG   DOE Joint Genome Institute;
RA   Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA   Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA   Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA   Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA   Visel A., Grigoriev I.V.;
RT   "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC       {ECO:0000256|ARBA:ARBA00008251}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ORY35539.1}.
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DR   EMBL; MCFC01000001; ORY35539.1; -; Genomic_DNA.
DR   STRING; 71784.A0A1Y2BL91; -.
DR   InParanoid; A0A1Y2BL91; -.
DR   OrthoDB; 5840at2759; -.
DR   Proteomes; UP000193986; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR   CDD; cd15482; Sialidase_non-viral; 2.
DR   Gene3D; 2.10.70.80; -; 2.
DR   Gene3D; 3.30.60.270; -; 2.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR   PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR   Pfam; PF15902; Sortilin-Vps10; 2.
DR   Pfam; PF15901; Sortilin_C; 2.
DR   SMART; SM00602; VPS10; 2.
DR   SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000193986};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..34
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           35..1483
FT                   /note="VPS10 domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012305157"
FT   TRANSMEM        1380..1401
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          59..713
FT                   /note="VPS10"
FT                   /evidence="ECO:0000259|SMART:SM00602"
FT   DOMAIN          739..1373
FT                   /note="VPS10"
FT                   /evidence="ECO:0000259|SMART:SM00602"
SQ   SEQUENCE   1483 AA;  165338 MW;  BCD4701DD457E905 CRC64;
     MAKRPIRKRQ YCNLVGFVLT LVLGLFFVPA GVLADDPEVT ITRLDNLPNR LFYFDDTPVI
     LIHDPVTLTV LRSADEGKTW NPISGVDSAV RLIPHPHNNE MAFIIGRRTT HWVSYNRGDS
     WQSFETSREA SLAGNTLSFH AEKPEWILFQ GVACDDTGDG KWGGGRTCWD ETFYTTDAFR
     TAPELLLAQT SQCIFARSTP DTAGAPEKLI FCVAFDPNTK PGPGGIHSYK DSRLFSSEDW
     FQNTKKFVDL GIGKKAKGVV GLGVVSKFMV AALRAADGES RRASGGDPMH LYVSTDGLEW
     RQTRFPHSAL PDLRENAYTI VESTTHSIAV DILTSPSANI GTLFVSSGEG TYFVQALADT
     NRNEYGIVDF EQLVGLEGIG IANVVANREE VVGWGETKKL KSVITYDDGS SWRPLKAPEK
     KVNGDDWSCN REDPSTCSLH VHSVTVPHNY GRIFSSNAPG YVMAVGSVGD RLLPYEDCDT
     FLSTDAGLTW SVVQEGAHKY EFGDQGSILV IADDEEATDH VHYSYDGGVT WEELNLGITV
     RTLVLTTIPD STSQKFVLLG TATRKDSGDG RHAMIFLDFA PLQHRQCIGT DMERWYARDG
     EGKECLMGHK QWYQRRKLDA LCYIGHKFKD PVGHEEDCPC TDTDYECDFN YVRQDGECVA
     VGPETVPAAT CAKPDDKYLG SSGYRKIPGN TCDQSSGIRK DEKIEKPCSL ARPENGKASH
     VTHEFDTIVS QYSYFSYSQT ILLELADGTI WQSSNEAFSW KQLAAGNSFL GVTMHSYAPE
     RAYLITNQRK VFYTTDTGRS WNTFTTPMEP NNLGIPILDF HPTKSDWLIY TGSTDCTATL
     SNNCHAVAYY STDHGRRWKQ IEQYVRTCAW ARDSRLKIDE REIICESYRN KKGSQKSGDY
     NPLELIAGAN YYSKKIKLFD AVVGFASFSE YLLVAQLNEQ AGTLTLQVSL DGYHFSEGQF
     PPSMRIENRA YTILESSTDS VFLHVTMNAA TNKEWGSIFK SNSNGTYYGL SVEHVNRNTA
     GYVDFEKMIG LDGIAVINVV TNPAEADISG NKKIQSRITH NDGGTWKPLN PPARDSLGVD
     YDCRSTACSL QIHGYTERRD PKATYSSPSA VGLMLAVGNV GEELAAYPDS DLFLTRDGGF
     TWEEVHKDAH MWEFGDSGSI IVLVNDEEAT DHVIYSLDEG LTWNEYSFEY PIRVRTIQTV
     PQDTSRRFFL LGERPSDPTK TVLIHLDFSA ITQQKCQLKI EDPNHDDFEL WSPSEGRDET
     CLFGRQTLYH RRIRDKNCYI GEAVEQPRSI VRNCTCTDSD FECEFNYYRD SSGKCVLVEG
     ATALSVSTEY EQCDGFSAFW YERTAYRKIP YSSCEGGDRP DRGKQHACPG LIGRPGLGGL
     FWGSIAVLPF ALAGLVGWWW FTKGSQGGSI RLGDHRAFGS DASSGALSTL ASVPYFLIGV
     AQASWAWVVR KVPVLEDLFG RRMPYRQVPL DDDAEILATY EDE
//