ID A0A1Y2BN53_9FUNG Unreviewed; 520 AA.
AC A0A1Y2BN53;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE RecName: Full=NEDD8-activating enzyme E1 regulatory subunit {ECO:0000256|PIRNR:PIRNR039099};
GN ORFNames=BCR33DRAFT_664309 {ECO:0000313|EMBL:ORY36173.1};
OS Rhizoclosmatium globosum.
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Chytridiomycetes; Chytridiales;
OC Chytriomycetaceae; Rhizoclosmatium.
OX NCBI_TaxID=329046 {ECO:0000313|EMBL:ORY36173.1, ECO:0000313|Proteomes:UP000193642};
RN [1] {ECO:0000313|EMBL:ORY36173.1, ECO:0000313|Proteomes:UP000193642}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEL800 {ECO:0000313|EMBL:ORY36173.1,
RC ECO:0000313|Proteomes:UP000193642};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.
CC {ECO:0000256|PIRNR:PIRNR039099}.
CC -!- PATHWAY: Protein modification; protein neddylation.
CC {ECO:0000256|ARBA:ARBA00005032, ECO:0000256|PIRNR:PIRNR039099}.
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. ULA1
CC subfamily. {ECO:0000256|ARBA:ARBA00006868,
CC ECO:0000256|PIRNR:PIRNR039099}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY36173.1}.
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DR EMBL; MCGO01000057; ORY36173.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2BN53; -.
DR STRING; 329046.A0A1Y2BN53; -.
DR OrthoDB; 5488891at2759; -.
DR UniPathway; UPA00885; -.
DR Proteomes; UP000193642; Unassembled WGS sequence.
DR GO; GO:0019781; F:NEDD8 activating enzyme activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045116; P:protein neddylation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR030667; APP-BP1.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR PANTHER; PTHR10953:SF29; NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR Pfam; PF00899; ThiF; 1.
DR PIRSF; PIRSF039099; APP-BP1; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000193642};
KW Ubl conjugation pathway {ECO:0000256|PIRNR:PIRNR039099}.
FT DOMAIN 14..512
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
SQ SEQUENCE 520 AA; 56856 MW; E565B31DF59D10AB CRC64;
MTAGTNGPSR EQKYDRQLRL WQAHGQKALE NTSILVVHAN ATATETLKNL VLPGIGSFTL
VDGKVVDGAD AGSNFFLEGS DIGRSRAQAA AALLAELNPD VRARAVVADV EKALTVSPEL
VTQHNIVVAS SLPQHILLPL AKLCAAENIP LIVVRAYGFV GHLRIQAVEH CIVESHPDTI
NDLRLDCPFP ELLAYANSFD FHALDNMTYA HIPYVVILLR CLEEWKSKNN GALPTTSPEK
TAFRQMVTSL KREGVEDENF EEALKGVFRA LQPTKIDSKV ASILEEARTK PITAETNNFW
ILAKAVAEFV DSENGKLPLA GVVPDMKSDT ESFVKLQTIF RDKAHKDVAK VHAIASNLSV
GATGPSLEET ARFCKNARNL VLIRTSTIES EYAEPYAGTM ADMPENNVQY YLALRGVDAF
YEEHKRYPGY HAEEVESDIG LLKKSCTAVV TKMGLKNVAV SDDIIHEMVR AGASELHTMA
SFMGGVCSQE AIKLITGQYT VLNNTFVYDG MRSVGAAHTF
//
