ID   A0A1Y2BYS2_9FUNG        Unreviewed;      1520 AA.
AC   A0A1Y2BYS2;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=3'-5' exonuclease {ECO:0000256|ARBA:ARBA00040531};
DE   AltName: Full=Werner Syndrome-like exonuclease {ECO:0000256|ARBA:ARBA00042761};
GN   ORFNames=BCR33DRAFT_828962 {ECO:0000313|EMBL:ORY39923.1};
OS   Rhizoclosmatium globosum.
OC   Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC   Chytridiomycota incertae sedis; Chytridiomycetes; Chytridiales;
OC   Chytriomycetaceae; Rhizoclosmatium.
OX   NCBI_TaxID=329046 {ECO:0000313|EMBL:ORY39923.1, ECO:0000313|Proteomes:UP000193642};
RN   [1] {ECO:0000313|EMBL:ORY39923.1, ECO:0000313|Proteomes:UP000193642}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEL800 {ECO:0000313|EMBL:ORY39923.1,
RC   ECO:0000313|Proteomes:UP000193642};
RG   DOE Joint Genome Institute;
RA   Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA   Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA   Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA   Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA   Visel A., Grigoriev I.V.;
RT   "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ORY39923.1}.
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DR   EMBL; MCGO01000037; ORY39923.1; -; Genomic_DNA.
DR   STRING; 329046.A0A1Y2BYS2; -.
DR   OrthoDB; 1660779at2759; -.
DR   Proteomes; UP000193642; Unassembled WGS sequence.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR   CDD; cd22744; OTU; 1.
DR   CDD; cd06141; WRN_exo; 1.
DR   Gene3D; 3.90.70.80; -; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR046616; DUF6729.
DR   InterPro; IPR003323; OTU_dom.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR13620; 3-5 EXONUCLEASE; 1.
DR   PANTHER; PTHR13620:SF109; WERNER SYNDROME-LIKE EXONUCLEASE; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   Pfam; PF20499; DUF6729; 1.
DR   Pfam; PF02338; OTU; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50802; OTU; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000193642}.
FT   DOMAIN          114..245
FT                   /note="OTU"
FT                   /evidence="ECO:0000259|PROSITE:PS50802"
FT   REGION          15..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          60..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          247..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        247..261
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        266..282
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        283..297
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1520 AA;  171777 MW;  DBC509B386E5225E CRC64;
     MVVSTNDITP LKIEMKQQQT PKTTKSKHGG AREGAGRKKA PLPAGQLKLD LVTFGIKRKE
     PMKSPTLPES HATNSHNETN ADVGDKDVDA NVLFNQPYSP LVIRTVKNES FTGKVSQFID
     GDGNCLFRCL SWFVHKGDQS HHRDIRRKIV GHFRKRSNVF ERLAAIDNMS LDDLCAKYET
     NGEFGDEYCL ASFCDLYQME VTVFSNINTQ YHVTVFTPQA RPASYMKISL HLSVSSDHYE
     VVLDSTQEFE TAPTGPNVSS YVPASDEGDG EDDDDGDSDD DEDHASNNSS TTRKRFIHRT
     DPNGAYLTQV CAAVRRGDHD AQLKLGNVLI LPPDPVSSLR KSVLRGGDYS PEFFLYSNLV
     VCNPYLTCDE SNVVCPNCNS NNTRQSGYSE EPRRIYGING LIYYLLAARG TCQDCKHKFR
     TTNAVTISKL LLHYQPKFNQ TLTKRAGVDD ELVFLLRNGL YQGLGPAGVH SLQRQKATYR
     HSLSELQYYS VVESLMVQSR TQPSVSMRKV IDPNDIPPFP SFTSPDYDGG YPSINYLKKI
     LVKDNLKRRD WLDFEVQRRS GTVLSIDHYY KICKHLAPIN GHRLFKALFT AKNEYREIRL
     QALTQSSGHL DLIPLFRSHE RTREYFGYSP ITLVYTDKCC SDRSFLQSVL EQSLPVGTAA
     KPLLPLPDNP LCVRLLSTER PTEITTALAR IIQHIRSLPN SSRMPLGLDT EWKVGPRGKE
     GKIQLLQLAI KEKLLNDESE TELILLVVLK DRFDWPPYLK EVVESPKTLK IGSRIVAADF
     KYLNEDWGIQ PRSLDSADIC DTGHLCKRKG FVEKANASLS KCCAAVLGYC LDKSDSVRCS
     DWSKPRYSQQ QKDYAARDAW AGLLIYLQLQ NAVDTSFSRL VLPTTVPEPQ VLENDSAGTS
     ADSLFRQLLE VENGVTVKLD SVHGMMRIEL PKKHPMAGVF AKKLRDAIFI LNPEDVKRVD
     EYLRTKGTTF EEELLRNPDW CLKRVRRSIP SSDILYDRVN ELLIEFSLDS YKDEKGVPLL
     SAKAKKDMKT LLNDHIRKGC LSDPADFPLY TKIGDDKDGL PLYATFRGTS DVESFHQLLE
     QIFSSMNCSP EFMDAVLSQI RHVFNIRASE RNRPGFPKIG HYEHYMIDAI NEITFRIYGK
     PIHKWWTVTS LFRPTSETFG IIPHLPEEEW EPVTEKDVES YPRTYRFLAL RTKCLIPYLP
     VHTPAEWRLF TQNLSFYVGK TAGGSSSKSG LENMALDWNS GKLPVCPKAP TISKEFIITR
     KLEAHLEDAH KVLLKRLQRK DLMNKNKTGM SSLDDSLAQF SELDFPYLAE FDGAEIGPFR
     VIFDENLVDS DSDMESYVTA EEPVGEFEFD TLPQVLQNAV NISFQPQPAA TVFLPSSNST
     LAVPFGTLPI TTPQPATILP KKPRKPRTCQ RCERQKCAGV WKQSKCDFVK PISTKTPTIR
     SITQRTSIPA LSIDSAALDA KIELFNDSMH GLYGNGDGIV WDPARSEQDL HYARTLFSAS
     NNIIIQLWIE KFMAARNNEE
//