ID A0A1Y2C2C8_9BASI Unreviewed; 703 AA.
AC A0A1Y2C2C8;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=DNA binding protein {ECO:0000313|EMBL:ORY41116.1};
GN ORFNames=BCR35DRAFT_285567 {ECO:0000313|EMBL:ORY41116.1};
OS Leucosporidium creatinivorum.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Microbotryomycetes; Leucosporidiales; Leucosporidium.
OX NCBI_TaxID=106004 {ECO:0000313|EMBL:ORY41116.1, ECO:0000313|Proteomes:UP000193467};
RN [1] {ECO:0000313|EMBL:ORY41116.1, ECO:0000313|Proteomes:UP000193467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=62-1032 {ECO:0000313|EMBL:ORY41116.1,
RC ECO:0000313|Proteomes:UP000193467};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY41116.1}.
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DR EMBL; MCGR01000138; ORY41116.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2C2C8; -.
DR STRING; 106004.A0A1Y2C2C8; -.
DR InParanoid; A0A1Y2C2C8; -.
DR OrthoDB; 5475669at2759; -.
DR Proteomes; UP000193467; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000193467}.
FT DOMAIN 226..345
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 355..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 703 AA; 77767 MW; B5A293494B81BACF CRC64;
MSAKPVPKPI RALDARTVSL VAAGEVIQRP SNCIKELLEN CLDAGSTSIR VTVKEGGLKL
LQIQDNGCGI RKADLPILCE RFTTSKIKAF EDLSQLGTYG FRGEALASIS HVAHLSVTTK
TRDESCAWKA AYSNGNMVPV KAGLKDSQPI PCAGNDGTLI VVEDLFYNTP TRLKSLRSSS
DEYSRIVAVV LHYSIHNAGV SMVCKKANAS TADVNTAVGA SVNDNIGLHY GEAVRKELVE
VVVEHAELGV KAKGWFSGAN YGAKKGTYLF FINHRLVDCT PLKRAFEGFY GTLLAKGSHP
FVYLSLEIDP TKVDVNVHPT KREVGFEDQD EIVELICDAL AKKLEKASES RSFKVQTLLP
GARPIDETSK PSRTKSDSST PKASTSSSNT RKAPPKSFVR TDHNTQTLDS MFVPVVDSDR
PSKRRKTAEG GAEVEASQQV ESQQAVRVKI PQSDTVLTSV KELRAEVIER NDEGLEAIVK
NHVFVGVADL QGSLSMLQHH QKLFLVNLAS LSEELFYQLG LRQFGRFVRI KLNPPPPLRD
LIRLAVEHEE GKEAAKMSTE EIIERIHSLL VDQRAMLEEY FSLSITEDGK LESLPLIVPG
YTPNLSKLPL FLIRIGIQVD WTAEKPCFES FLRELAFFYI PGPAPFAYDK ELTKEQEASE
TRQIQHVVFP AAKQYLLPPT RLLKKDVVQV TSLESLYKVF ERC
//
