ID A0A1Y2C862_9FUNG Unreviewed; 797 AA.
AC A0A1Y2C862;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=LY90DRAFT_385200 {ECO:0000313|EMBL:ORY43220.1};
OS Neocallimastix californiae.
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Neocallimastigomycetes; Neocallimastigales;
OC Neocallimastigaceae; Neocallimastix.
OX NCBI_TaxID=1754190 {ECO:0000313|EMBL:ORY43220.1, ECO:0000313|Proteomes:UP000193920};
RN [1] {ECO:0000313|EMBL:ORY43220.1, ECO:0000313|Proteomes:UP000193920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G1 {ECO:0000313|EMBL:ORY43220.1,
RC ECO:0000313|Proteomes:UP000193920};
RG DOE Joint Genome Institute;
RA Haitjema C.H., Gilmore S.P., Henske J.K., Solomon K.V., De Groot R.,
RA Kuo A., Mondo S.J., Salamov A.A., Labutti K., Zhao Z., Chiniquy J.,
RA Barry K., Brewer H.M., Purvine S.O., Wright A.T., Boxma B., Van Alen T.,
RA Hackstein J.H., Baker S.E., Grigoriev I.V., O'Malley M.A.;
RT "A Parts List for Fungal Cellulosomes Revealed by Comparative Genomics.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY43220.1}.
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DR EMBL; MCOG01000117; ORY43220.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2C862; -.
DR STRING; 1754190.A0A1Y2C862; -.
DR OrthoDB; 150430at2759; -.
DR Proteomes; UP000193920; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03684; ClC_3_like; 1.
DR Gene3D; 3.10.580.20; -; 1.
DR Gene3D; 3.90.1280.20; -; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR PANTHER; PTHR45711:SF6; CHLORIDE CHANNEL PROTEIN; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|ARBA:ARBA00023214, ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000193920};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 131..159
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 212..233
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 317..341
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 394..412
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 432..452
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 487..507
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 513..535
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 644..705
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 742..797
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 797 AA; 89668 MW; 411B2D0E76D83C43 CRC64;
MDTRNNNLFN NDDNNYSLSH NENEFSSASA SASASVSASA IHIIDSEYAS TNNSQKKSID
NIVEERENNI SIYSYDQIKH KKKIRKRGST VSGKRVEYEN FTTIDWNHDF AKDRNRKNKL
KKRKSLKGRL YFIYDVCQPW ILVILIGIIT GLLAAFIAIS ADWISDIKEG HCKSGFYLNR
KFCCWGNPGY QCPDWEKWSD FYNIQSNFFK KIINLFMYTF IACLATFVAA YLVRDFAPYS
AGSGIPEVKT ILGGFVIKKF LGFRTLIMKC IGLSLSVGAG LSVGKEGPLV HVGCCVGNLC
SRLFNKFNNN GARRREALSA ASAAGVSVAF GAPIGGVLFS LEEVSYYFPM KTLWRSFLSA
LTGALTLQLM NPFRSGKVVL FQVAYTRVWH VFELPIYILL GAIGGLYGAF FIKMNMKVVR
LRKFSWLKKY PIQEVFVVTL VTSVVSYGFL FLRVSMTQLI SNLFRECSEL ESDFGGLCNK
EKIKSTVFML LIALVLKIIM TIFTFGIRVP AGIFVPSLAV GALIGRIIGI LMQLWQESHP
DLWIFSSCNP DVQCVTPGVY AFIGAAATLG GVTRMTVSTT VIMFELTGSL SYVLPVMITV
MVSKWIGDAF DKDSIYDALI DLNQFPFLDS KREYYSDAIV SDIMTNVDNI ILLPAIGLTV
NDLENILQEY PYQGFPIVNN TYDKLLIGYI GRSELRYTID QAHGIENVDG SVQCYFTKKS
PDVYGINNSQ KQQKYLDLRP WIDSTPYTIS PNYKVVKVLE IFKKIGLRHV MIVKRGKLVG
LLNKKDLLRY LATLKDN
//
