ID A0A1Y2CJV2_9FUNG Unreviewed; 1177 AA.
AC A0A1Y2CJV2;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 13-SEP-2023, entry version 19.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LY90DRAFT_457428 {ECO:0000313|EMBL:ORY47134.1};
OS Neocallimastix californiae.
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Neocallimastigomycetes; Neocallimastigales;
OC Neocallimastigaceae; Neocallimastix.
OX NCBI_TaxID=1754190 {ECO:0000313|EMBL:ORY47134.1, ECO:0000313|Proteomes:UP000193920};
RN [1] {ECO:0000313|EMBL:ORY47134.1, ECO:0000313|Proteomes:UP000193920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G1 {ECO:0000313|EMBL:ORY47134.1,
RC ECO:0000313|Proteomes:UP000193920};
RG DOE Joint Genome Institute;
RA Haitjema C.H., Gilmore S.P., Henske J.K., Solomon K.V., De Groot R.,
RA Kuo A., Mondo S.J., Salamov A.A., Labutti K., Zhao Z., Chiniquy J.,
RA Barry K., Brewer H.M., Purvine S.O., Wright A.T., Boxma B., Van Alen T.,
RA Hackstein J.H., Baker S.E., Grigoriev I.V., O'Malley M.A.;
RT "A Parts List for Fungal Cellulosomes Revealed by Comparative Genomics.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY47134.1}.
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DR EMBL; MCOG01000105; ORY47134.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2CJV2; -.
DR STRING; 1754190.A0A1Y2CJV2; -.
DR OrthoDB; 23973at2759; -.
DR Proteomes; UP000193920; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00014; CH_SF; 1.
DR CDD; cd05992; PB1; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010481; Cdc24/Scd1_N.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR47339; CELL DIVISION CONTROL PROTEIN 24; 1.
DR PANTHER; PTHR47339:SF1; CELL DIVISION CONTROL PROTEIN 24; 1.
DR Pfam; PF06395; CDC24; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF15411; PH_10; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000193920}.
FT DOMAIN 171..345
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 369..483
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1076..1158
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
FT REGION 525..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..759
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..861
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 865..923
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..952
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..1011
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1024..1070
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1177 AA; 135346 MW; 8914DA3D84BD870D CRC64;
MNIELPVAIN ARTNTESLYQ QCLKLIEKIY PLDGFPEILF PDNDFSKISD PVKIIWDMCR
LGYPLCLLYN ILQPSTPLEV KQGDNMSKTN ASKRSVFLFI QACRTDLHIP EDELFKITDI
FKEDTNLFVK VVNVLNILIK AIEERGFYPQ NTKPLPFNIP NSNEIESPKD NRAKLVAELL
NTERAYVQDL ERLHNYQLEA ESKILSKEDS IILFSNLGEL LDFQRKFLIH MEAALAVPTQ
EQRIGHLFSS MESGFKVYQI ICANQDKAAK FALNNCEVLM SLASVMEPKY ELPSYLIKPV
QRICKYPLLL NELMKYDTKA GHPYCHELQQ GLDAIKRVTK LTNEIKRQEE NEVLTEDLKN
NIQDWKSVKV NELGLLLLRG NFTISIGENE REYLIYLFQN MLLCCQEKKK KGKTKVSYIL
KGSIYISSVT RVSKAANIAV VNDSTFALKI YWSDKVVNQC IILKCISEEQ IDRWVAQFEK
LIEIEKQKKQ GSTIKENYDY DNHYISRVNQ VDGLFTDEEY ENKSVHSTHS MYSKPTSRNH
SMQPSPKNLS RSKSQPNIFN HVGNDFRNNS KNQDVPPVPS FPQEYSYGHK INDSYGSSSV
NISNSSSLSH SNSSFSSSNN SMMSHKNISI YNNDNSSQDS LVAPQRTVST HVKHNKSLNN
MNLRNVSKYN EPDEYNLRPK SPSPNQSYRV KSSIPLPPTP PSNPSRPSLY HSKSNSNLDE
DGNIINIPER KVSSNSKNHS RPSKINIEEY SNNKYGSTKA SESYEKDEMS SLSPGSSHSN
NLSSSINDRE PSSPTQNAYY YPVRNQYPNG NSFYKRGDYN SENTSYNKSM NDYNGNNNDY
NVSRNDKRSD MGGSNMYNGR KSEYANEGLE YERNKIHDHN RSRSRDLRSP RERNGYDRPD
MEDYEHYGRR RDYREEDSYN MSNRSRSRSR PKNPNPLYRN PSNLNNGESF SRDSGNFEKD
RPQPLSNERI LRNQNSVSSL SYDVKKDSNN TNSNLSSNED SNTNHNISPR VRPSPPNTPN
SRPSTPSTRP TTPSSRPTTP NLSSRLNNMN IRRPSTPLTS NSYNNNNNTE NLRSSYTKIK
VSYKDQEFVI PAPSSGLTYR ELLSKIERKI RLNDRNINDT RPLRIRYKDE DNDFVNITND
EDVLLAFEVS NKIWKFNKEL NNESISSMAV NLFVDRK
//
