ID A0A1Y2CQ25_9FUNG Unreviewed; 1046 AA.
AC A0A1Y2CQ25;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 22-FEB-2023, entry version 19.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0000259|PROSITE:PS00486};
GN ORFNames=BCR33DRAFT_753229 {ECO:0000313|EMBL:ORY49140.1};
OS Rhizoclosmatium globosum.
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Chytridiomycetes; Chytridiales;
OC Chytriomycetaceae; Rhizoclosmatium.
OX NCBI_TaxID=329046 {ECO:0000313|EMBL:ORY49140.1, ECO:0000313|Proteomes:UP000193642};
RN [1] {ECO:0000313|EMBL:ORY49140.1, ECO:0000313|Proteomes:UP000193642}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEL800 {ECO:0000313|EMBL:ORY49140.1,
RC ECO:0000313|Proteomes:UP000193642};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY49140.1}.
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DR EMBL; MCGO01000010; ORY49140.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2CQ25; -.
DR STRING; 329046.A0A1Y2CQ25; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000193642; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756};
KW Reference proteome {ECO:0000313|Proteomes:UP000193642}.
FT DOMAIN 925..941
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1046 AA; 117278 MW; CF29F9C2C54EF462 CRC64;
MLGKNKKTPT SAAKSGQNQR TITSFFAKPN ATTPARAVGP SASQSLGQPE PHPHPQQQQQ
QQLPSAQPQQ QPPSIQTTTA QSLPPRESDK MDEDHDDDND NDAPVLAKKR SKFVVADDDS
DDDAAKVETL KKRKTNDDDD EDKDKFNSDA MKTPARKSLD KFASPRFDFV QKTPASSSSQ
VQYLGNPFLG YGIHSCLRFK ANSLDFNRQK AARAMDFKER NQDRYAFLLD ERDADKNRPG
EPSYDPRTLY IPPSAWSKFT PFEHQFWEIK SKHWDTVDAD VASKEFDWKC TDRVNMKMCG
VPENSFDHWA SQFVARGYKV AKVDQVENAI AKDMAKKKNG PSGNKKEDSV IRRELTMILT
AGTLVDTQLL TSEMSTYCMA IKEEVNAGDS AEPLFGVSFV DTSTAEFNIS YFRDDADRTH
LETLLLQLKP KELVLEKGCL SAKTQKVLKN CLNDPQCNHL IPEVEYWTVE ATLDELQRPC
YFGVAGEGGA VEVKYPDAVN RIRDEPLAMA SLGGLLSYLR SLKLDKDLVS ARNFQIYDPL
RRSGNLILDG QTLLNLEVFE NTSDGSSEGT LFKLLNHCVT PSGKRLFKTW VCHPLQDIAA
INSRLDAVDD ISGCPDFQDE VTTCFRKLPD LERIISRIHA GTSRVKDFML VLKGFTDIFN
LMVDVQKFAE NFKSTRLVQL LTTTDAQHLR DELKFFEEAF DHSEGLNTTE INANAGFDDV
YDEAAAQLEG IADEFESYRK EKERSLGVKC GYKDLGKDLY QLEIPTWIVQ TKTQAVTRYY
TPETKAMLER YLEAREERGQ ALKNVRARMF ARFDEHYLRH PCIHTESGKE FIPNDTVLGG
EGGSTMILLT GPNMGGKSTL LRQTCIAVIM AQLGCYVPAA TCRLTPFERI FTRIGAHDNI
LAGQSTFMVE LSETSKILRE ATPRSLVILD ELGRGTSTFD GFAIAFSVLY QLITQTKCLG
LFSTHYGMLT KEFEDNGLVS LKHMSFVADE EKHSITFLYK LTDGACPKSF GMNVALMAGV
PSSIVDTAER VASEFESKLK MTRTTG
//
