ID A0A1Y2CRX2_9FUNG Unreviewed; 1041 AA.
AC A0A1Y2CRX2;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Antiviral helicase {ECO:0000313|EMBL:ORY49800.1};
GN ORFNames=BCR33DRAFT_781343 {ECO:0000313|EMBL:ORY49800.1};
OS Rhizoclosmatium globosum.
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Chytridiomycetes; Chytridiales;
OC Chytriomycetaceae; Rhizoclosmatium.
OX NCBI_TaxID=329046 {ECO:0000313|EMBL:ORY49800.1, ECO:0000313|Proteomes:UP000193642};
RN [1] {ECO:0000313|EMBL:ORY49800.1, ECO:0000313|Proteomes:UP000193642}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEL800 {ECO:0000313|EMBL:ORY49800.1,
RC ECO:0000313|Proteomes:UP000193642};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000256|ARBA:ARBA00010140}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY49800.1}.
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DR EMBL; MCGO01000008; ORY49800.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2CRX2; -.
DR STRING; 329046.A0A1Y2CRX2; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000193642; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 2.
DR Gene3D; 1.20.1500.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF8; HELICASE SKI2W; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 3.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ORY49800.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000193642}.
FT DOMAIN 184..296
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 395..595
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 91..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1041 AA; 114994 MW; 827A9B22B0F77315 CRC64;
MRSTWTNFEF GFGWTQTVPP GFDRGLSLKV LYCLFLLTDV PVLTFETSPS DTDQVPAYAH
ETVLNIQDIL GSTGDDFGLF DAPTIQVELV TPETQREQPT DESKDTEQSS LTADLDDLIP
TKEVVPVVAT KAAKPKKEAL KEWAYVVDVN QPFPDFYEKV PELAHKFSSP RTHPRKNRSG
RIAIALAQKH MTRAIYTSPI KALSNQKFRD FKDPSCLIMT TEILRSMLYR GADLIRDVEF
VIFDEVHYVN DAERGVVWEE VIIMLPAHIT LILLSATVPN TREFADWVGR TKKRDIFVIS
TQKRPVPLEH HLYVEKEIYK VVGAEKKFLS AGWEGGAVAA AAGRGGRGGA VARGGGRGGG
AAGGANRGGG GGGGGGSGGN NSFSRDVADR NMYVNIISLL KKKSLLPVIV FSFSKRKCEE
YANALVNLDL TSGSGEKSEI HVFIERSLAR LKGTDKQLPQ VLRIRDLLSR GIAVHHGGLL
PIIKEMVEIL FTRGLVKVLF ATETFAMGVN APARAVVFSS TRKHDGRNFR ELLPGEYTQM
SGRAGRRGLD DTGVVIIACS DEVPEPTMLN QMLLGVPTKL ESQFRLTYTM ILNLLRVEAL
KVEEMIKRSF SENTAQKMLP EQQSMYDESA KALSNLQKLS CSICTDIGPF YDASSKVVLL
GHQLREKIMR SPLGSKVAVP GRVIIVNSGF FRNVVGVILK PGIVPPVSAS HETARREATA
DGRAFIVLAV VENMGSGANP YAGVDLSPMP VTRVSLPAAS RQAFEVIAVP YSDMSVITKH
VIKIDQDQIL ESKLSAEATR VGQLLVSLAE EMAQESRIPE NDWSKIRELE FQEKEKEKNA
LLAKLSSFQC SKCPDLVEHY GIIHNERQLE VQLAELAHNI SDQNLELLPD YHQRIEGRVA
CEINTADELI LTELILENFL ADYEPAEIGI EEIKNIAIKV HSVQKMCGLD VGGPEDAIAG
LKFGLVEVVY EWARGMSFKE ITELTDVLEG SIVRCIVRLD ETCREVRGAS RIIGDSNLHR
KMEEAAESIR RDIVFAASLY F
//
