ID A0A1Y2DAG4_9FUNG Unreviewed; 433 AA.
AC A0A1Y2DAG4;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=tRNA guanosine-2'-O-methyltransferase {ECO:0000313|EMBL:ORY56260.1};
GN ORFNames=LY90DRAFT_669443 {ECO:0000313|EMBL:ORY56260.1};
OS Neocallimastix californiae.
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Neocallimastigomycetes; Neocallimastigales;
OC Neocallimastigaceae; Neocallimastix.
OX NCBI_TaxID=1754190 {ECO:0000313|EMBL:ORY56260.1, ECO:0000313|Proteomes:UP000193920};
RN [1] {ECO:0000313|EMBL:ORY56260.1, ECO:0000313|Proteomes:UP000193920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G1 {ECO:0000313|EMBL:ORY56260.1,
RC ECO:0000313|Proteomes:UP000193920};
RG DOE Joint Genome Institute;
RA Haitjema C.H., Gilmore S.P., Henske J.K., Solomon K.V., De Groot R.,
RA Kuo A., Mondo S.J., Salamov A.A., Labutti K., Zhao Z., Chiniquy J.,
RA Barry K., Brewer H.M., Purvine S.O., Wright A.T., Boxma B., Van Alen T.,
RA Hackstein J.H., Baker S.E., Grigoriev I.V., O'Malley M.A.;
RT "A Parts List for Fungal Cellulosomes Revealed by Comparative Genomics.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC tRNA methyltransferase complex that mediates the methylation of the
CC guanosine nucleotide at position 10 (m2G10) in tRNAs.
CC {ECO:0000256|ARBA:ARBA00002425}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY56260.1}.
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DR EMBL; MCOG01000074; ORY56260.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2DAG4; -.
DR STRING; 1754190.A0A1Y2DAG4; -.
DR OrthoDB; 5488599at2759; -.
DR Proteomes; UP000193920; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR13370:SF3; TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG; 1.
DR Pfam; PF01170; UPF0020; 1.
DR PIRSF; PIRSF017259; tRNA_mtfrase_TRM11; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51627; SAM_MT_TRM11; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ORY56260.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000193920};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ORY56260.1};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 179..297
FT /note="UPF0020"
FT /evidence="ECO:0000259|Pfam:PF01170"
SQ SEQUENCE 433 AA; 50179 MW; 7C0F6AB9BC083066 CRC64;
MIPYLVYFVQ FHEDFRLPEL EALAKLENVK IKFNREEYSN DNPFFIVELE SDEEAKRLIR
RSILIKYIIQ LWTTGNDYPE VYKNLKSFDS EKYKPYETST FKFMVETYNG TRTMKEQVDI
INTFSFLPFT GNIDLKKPAN TFMVLEKYPA PTEPPCKIYM GKLVGSGDRQ LVATYDLKKR
KYLGTTSMDA ELSLIMSNMA LVRQNSLVLD PFVGTGSFLI TCSHYGAFTL GSDIDGRQIR
GKGKTSIATN IEQYNMKKRV LGTIVSDMAH HPWRNNGELF DAIVTDPPYG VRAGAKKIGL
NTEKYDAPPP TKRDVMNPRY PLTVPYEMEQ VLIDLIEFAS KYLVIGGRLV YWLPTNSEEY
NKNDIPQHPS LKLIANSEQS FGKWSRRLIT MEKIKKYEDI RLTGEGNTGH YQFRHFYFYG
KDQDHNSDEE KRN
//
