ID A0A1Y2DPW4_9PEZI Unreviewed; 1702 AA.
AC A0A1Y2DPW4;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=BCR38DRAFT_347380 {ECO:0000313|EMBL:ORY61300.1};
OS Pseudomassariella vexata.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Pseudomassariaceae; Pseudomassariella.
OX NCBI_TaxID=1141098 {ECO:0000313|EMBL:ORY61300.1, ECO:0000313|Proteomes:UP000193689};
RN [1] {ECO:0000313|EMBL:ORY61300.1, ECO:0000313|Proteomes:UP000193689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 129021 {ECO:0000313|EMBL:ORY61300.1,
RC ECO:0000313|Proteomes:UP000193689};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- SIMILARITY: Belongs to the UPL family. K-HECT subfamily.
CC {ECO:0000256|ARBA:ARBA00006331}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY61300.1}.
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DR EMBL; MCFJ01000010; ORY61300.1; -; Genomic_DNA.
DR STRING; 1141098.A0A1Y2DPW4; -.
DR InParanoid; A0A1Y2DPW4; -.
DR OrthoDB; 1093891at2759; -.
DR Proteomes; UP000193689; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR045322; HECTD1/TRIP12-like.
DR PANTHER; PTHR45670; E3 UBIQUITIN-PROTEIN LIGASE TRIP12; 1.
DR PANTHER; PTHR45670:SF1; E3 UBIQUITIN-PROTEIN LIGASE TRIP12; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000193689};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 1349..1702
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..1003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1038..1084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..40
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..611
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..939
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..978
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1083
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1669
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1702 AA; 187368 MW; 893906E39193B211 CRC64;
MAGTEEHEKE ADPPPPPPPP AHDPDDDSDD DDDDDDEPHR HYDDDDPFGG FGGPPGSGLS
STLRALTGMM SGMPSRLREL LNNLRMKEDP SMQMIALQEL SEILLVSNED NLAGHFSPDS
FVKELVVLMQ PNEITGEENP DMMLIACRCL ANLMEALPAS AANVVYGGAV PVLCQKLLEI
QFIDLAEQSL STLEKISVDY PTSIVREGGL TACLSYLDFF ATSTQRTAVT TAANCCRNIP
EDSFPVIKDV MPILLNVLGS NDQRVVEQAS LCVTRIIESF KYQSSKLEEL VSVDLLKAIL
RLLVPGTTNL IRANIHTQFL RVLAITARAS PRLSAELFKL NVVETLYQIL TGVSPPDETE
DVASKLDSVV IMQALIHRPR DQIIETLNVV CELLPGLKWI DLSTPQIPTG LDVSEPITPS
SVGGPRKKSS NEKRLEFLDE CKDQVRRFAL ILFPTLTDAF SSTVNLSVRQ KVLTAQLKML
SNLDKDILVD ALKSVPYASF LAAILSQQDH PSLVMSAIQT TELLLTRLDD IYRYQIYREG
VISEIAKLAE DQETAEPKGA ETTPMESNTE PSMGSADGGG SDRVSIHNDS EEEEEDDEDE
EDNDDEDHEN DHHDDDMSGS PVSSDGSTMS LDGPPRTFLA DIPSIKSRIA EVAKKFLEAH
ETEKQGKSMK KKALKILTDL QSLASDIESF YLQRTAKNLA PEQGTALFER LSAYFDADVL
ESVTSAELLA SGLVRVLEEV FSNPDEALAN AARSAFLEVF MGRSVKSRPK TTSADSPATP
FSVMVHKMQD LLSRSEHFEV LTVHQNTFDG NRSSAASMLA KQIRLKLVAD DDSDIPRSYR
NIMVSIHAIA TFKALDDYLR PRISLHERPR GPRPRDGLSR ALAAMAGSAG LPPERLAERL
GYSSTPAPPP PVPAQSSSSR PAKKPRPKSS GQTDAPATPN PPAGSAREKV SLRRSTRRNP
APPSESQAPP PPPPPEEEDD LQNALECADE KQLSDDDEDE VPDSSALDAI VGDLDEDMED
APVPDPSAVN LEVAAGGKIT ARKEDGTRIP TPSQSGLGNV PNRSVAHPPS GLSQQSTPTP
AMAPSRPLSY AAAIQAVPQD WHIEFSLDTR VIPNETTIYR AVHRTSPPAD EHFSRSVWSA
VHAIKFRRVP GPPPAEPIGF ATSTDESTDI NGTPASLANN PTTASILRLL KMLHDLNANI
DDILIEDKTA LRLNVEPLSQ FVNTKLTAKL NRQLEEPLIV ASNCLPGWSE DLARLYPFLF
PFETRHLFLQ STSFGYARSM SRWQNAQQEE TSRRDRRDER PFLGRLQRQK VRISRTKILE
SAVKVMELYG ASQSILEVEY FEEVGTGLGP TLEFYSTVSK EFSKKKLKLW REMDSNDSEV
FISGPHGLFP RPMAKDDVNS ERILQLFKML GKFVARSMID SRIIDLNFNP IFFRIGDGTT
GVKPSLGAVK IVDAGLANSL KHIKKFASAK KEIDEDPNRD AAQKVADTEQ IVIDNIKIED
LALDFTLPGF PDIELIPNGS HSPVTIYNVD MYLDKVVDMT LGSGVKRQVD AFRAGFSQVF
PYSALSAFTP DELVALFGRV DEDWSLETLM DSIKADHGFN MDSKSVKNLL QTMSELTAAQ
RRDFLQFTTG SPKLPIGGFK SLTPMFTVVC KPSEPPYTSD DYLPSVMTCV NYLKLPDYTT
IDSMRRQLFT AIKEGQGAFH LS
//
