ID A0A1Y2DXH6_9PEZI Unreviewed; 2571 AA.
AC A0A1Y2DXH6;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=GTPase-activator protein for ras-like GTPase {ECO:0000313|EMBL:ORY63947.1};
GN ORFNames=BCR38DRAFT_485089 {ECO:0000313|EMBL:ORY63947.1};
OS Pseudomassariella vexata.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Pseudomassariaceae; Pseudomassariella.
OX NCBI_TaxID=1141098 {ECO:0000313|EMBL:ORY63947.1, ECO:0000313|Proteomes:UP000193689};
RN [1] {ECO:0000313|EMBL:ORY63947.1, ECO:0000313|Proteomes:UP000193689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 129021 {ECO:0000313|EMBL:ORY63947.1,
RC ECO:0000313|Proteomes:UP000193689};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY63947.1}.
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DR EMBL; MCFJ01000007; ORY63947.1; -; Genomic_DNA.
DR STRING; 1141098.A0A1Y2DXH6; -.
DR InParanoid; A0A1Y2DXH6; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000193689; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR CDD; cd05392; RasGAP_Neurofibromin_like; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF150; INHIBITORY REGULATOR PROTEIN IRA1-RELATED; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000193689}.
FT DOMAIN 1205..1398
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
SQ SEQUENCE 2571 AA; 287671 MW; 7879ED321012A8EF CRC64;
MNGDAGLVGS LVERLTTRLP HRTGTQAQDL RHDDIAVISR ATLLKISASS ISVVLGALVT
LLEELCRPYK SFGIHPPHVV LSELYVLALA ADCCSAHWQA ALGNGTKAGA ATYGHVKPSS
AAQQHLHPLD DQLVTRICDY LKTVLDPMPD GYMLPARTIL DNETTRDILE LRLGESPSRV
ASSDGSDEFV ETSRMRNSHV REIEPHARTI VEFMTASSWQ PTFEYFRGVI YSIRTAVPIQ
PSAPQPLALA EDERSSLVIM RLLSYWWVDG QKLGILLQEL CSSFLHFRKP FQNTVAIVVP
LLIIRWLDRY PNEFVMLHNQ HRRLDGGPDT LFDMTQTIVD NGRRRIMLYP FQSMLLFLIP
DVFEVASNLR EIKGSGMGKR VQFLEGLRKA LRNRNEAAGY CLVCILRAAR HFDMDSDAAI
VSYAMDVQDE VRDAVFRRYS STDSSGVFDQ DLTTAAFIGL THLNFEGTVE SLSQTCLHPS
SPQTFKIAII QACSYFAREH DAEEYRPLFV EVAGFIQSQL RTMSAISAEM YISDYTLQRR
GSETSAPSIS MICNILNFLD ASPTTLFENA SPDTTVDFYE NNFEAFVSCL VSADEQVRAL
ASVLAKRLLA EDGILASLRK IKRLDSQGFK NKFWRLTSLV LLKMIEKYDQ EDGGAVLKSI
HGYLKSRLLL LNSIKELSEV SEDIAERTTA STKLETLFLV SLCSADIETC ELVTTCIGLF
NQECRLIDSA SEAAKTGPPL LRNSDIFGEI ASRDFRFTGI VAFQKRIRGL LRRMQYPSVG
ILDAWEFAFD RWIHLSKDVS ATPVDNVDDR MLTEWRNYSG FLASLGGICT AEQAFVLEEP
AIGGLRWIDR LSTDNIEEPL LHRFLRLSIQ LLACPNVRVR ETMREVLSAE IAPSLYQPLF
KGLESELEIL FTGALETSGK VQQDAEIIFA EQAASLLRAL VERLVTPSEL GAASSVHLGS
LTLSFAKFLD GYTDNPSCLR IKIKVCQLCE IVTKKKEHLN LRDDVRIRNQ LLEYIFGWIA
RPRSPRQDAY NGRQDEMARC QRDLDKACLR SLAELTFRLP LQPGDGQNDA GTSELKSQMF
HTYFNRFLSL LNYDPMEAHR GDLAGPLGQR DDTTPTADLA ITILSNLLSA NIDVGLKHSL
SIGYHENVEI RTAFVKVLYN ILVQGTEFSN LSDAAVSEKY EELLELLTHD MHLAVAISSI
CPSNEVDELT ISLLNVFETR GLTYELMDAL IKQEIEETEN ESEILRRNCV ATKMLSVYAK
WKGAQYLRDT LQKVVERLML TSKDLDLELD PARIQSQEEV QKNALQLRIV AKVFIDDIRA
SSANIPTSFR KICSIISSAV MPKFPEAKYT AVGAFIFLRF FCPAIVAPDA EGLVSTAPSK
EMRRGLLLIA KVVQNLANNV LFGAKEPYMF PLNDLLTQNI YKVTTFLREI SVPPEIPVAR
PTEGETFDFG SCVALHRFLY DHWDQVRQRL MSQERRDYVR SPVEVARGRS PVLEPLRALI
TNLGPPPLAV TWNRPQISAN SPPSYSRFQH FMLRNAFRST ESFMTSRAVY DGGESKDGLS
IICVILRHID SESIDYDTLL HCYLKIASRL WHRPFGLLID ATCYNGQNEP QDDIFKKLEL
LSPTELSRML SRIYVYNMNS AFRKCLRRIL RVATKSDTSI FNPGNVDYHL IGSLQDLQAH
FHLSQLHLPK DTISVVTDTR YVFQPITRLS KTKGKIEVTI KVGSQFVQVT TAKKQEVHPG
FRLHATVNDI FRLGDVDEAP TSIPTEDDSA FGLRADNGKI VMYFQSPKKL DVLQAVRGAK
AKYAKDTRAM KSFERLIRPQ DVPGTLLNLA LTNLAAPDPV LRLSSYNLLG ALCRAFKFKA
ASKFMCIRDV SVPLDPTQFI VNISKVLAHE EPQLTSDFLN EFFVGWESFS DEQKPLSLAY
MAPWLPSLRT SLLGDEADSE KGKEKIAAIF RKLIDVCITD PTLGLTLEHT VWPSIYKDET
LLDIFLEEIL KAALSLGFYD EQTQCLTSIV TAIGTITLRG KIISRLRKAL NRSSQRPTKY
LPDNAVWSEI CVLLQFCLSL SFDCGVQSQV YLPEIFHIVT MLANTGPSDV RVLVHRLLIN
SIHAACTSFK LDDAKLSKLR STLETLSEPR NDVFAAPVFS RDGASISTNQ ETGPTLSSTE
NLASLLFEIC SIAGPSVDMA NAWRSRWMSL VASTAFQNNP AIQPRAFTVM GCLAREEVDD
DLLYQVLVAL RNSVGRHGED HHNEMLVAIV TSLSKMMGKL NTASRYGFQL FWLAMSLLRL
VPPNLFNCAA NFLEAVLTNI GTSSELRSEK MAQLLLQGRV QLEEAALPLD DAYGIHFAAE
NFPFAVCACL VRGLTDTVTR ATALRVLSTF LEMTNTSAST FLSEKVPRNL QSSPYLALIQ
ARAVELEEFK DTLWLSGINP TNVVGLSTSR GLRDLSAISD KDLLLNTAIE LVDFQYLEDV
VQNRTLVWLN ELAVGRPAVI MHLAAPIAHI LDDILLHCQN SVTLASAHIL LQSIASNPKV
AKSIDSTGVL NEILEDMGFG GLWRSCSFNQ AQEPDKQCFA LTEKLIELII V
//
