ID A0A1Y2DYS9_9PEZI Unreviewed; 779 AA.
AC A0A1Y2DYS9;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Ras guanine nucleotide exchange factor {ECO:0000313|EMBL:ORY64369.1};
GN ORFNames=BCR38DRAFT_458069 {ECO:0000313|EMBL:ORY64369.1};
OS Pseudomassariella vexata.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Pseudomassariaceae; Pseudomassariella.
OX NCBI_TaxID=1141098 {ECO:0000313|EMBL:ORY64369.1, ECO:0000313|Proteomes:UP000193689};
RN [1] {ECO:0000313|EMBL:ORY64369.1, ECO:0000313|Proteomes:UP000193689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 129021 {ECO:0000313|EMBL:ORY64369.1,
RC ECO:0000313|Proteomes:UP000193689};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY64369.1}.
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DR EMBL; MCFJ01000007; ORY64369.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2DYS9; -.
DR STRING; 1141098.A0A1Y2DYS9; -.
DR InParanoid; A0A1Y2DYS9; -.
DR OrthoDB; 4819765at2759; -.
DR Proteomes; UP000193689; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF348; GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED; 1.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000193689}.
FT DOMAIN 291..417
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 524..762
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 173..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 779 AA; 87170 MW; 37263C62ABAE1A53 CRC64;
MEAINVVVIG ANGVGKSNFI QRAMALSRAP GAQPTMARIN IDNMPYAVTL FELDLEYFDV
DPDRRIQWPR QIGGAIMPPA HGVLLLFDVM NRDSIIELPQ TLSALVHSSL PTVLVATKCD
NPESARQIQT DSVAEACKSC IDSFKTSVNK PETARLALST LLKALVAGRQ DDAAVGPGTR
RRAASEAHLD APADSAIRRP LSQESRHSRA SSDMSLLRGM SNQSGQGRHD GTGDESSQTV
SSMLRTSGIR LDRQNSMSSS FIEIEESDAD SFRYSDDIPI LQRNDDTLFE RPAKKAGITF
DELVDRLIAP KLSRADSNFS EIFLCLYRKF AAPGELFAAI LSRLDGVKED KSLHYLTKTS
TQLRIIEAIA KWVASYPGDF ARPATRRNLD DFIKHLSTEP IFAAAARQMR RNLEQCVFED
DDTGWAKADD MDDDLAEGGS SSVKDTAKAS HELTESMSSL GTDENTDRRP SASSSLHTEL
SLASKVHQFQ FHSYEDYERE AATMIPSYTM PLTKFRYHIF MDTADDDIAD EMTRIDWVMF
SSIRIRDLVR HVSLNAEQKD KCKSMKNVNR MITHFNHIAK WVSNMILMRD KAKHRAQMLE
KFMNIALKLR QLNNYNSLAA VLAGINGSAI HRLAQTRCLV PADVQKRFAR LVLLMGTQKS
HFAYRLAWEN SPLPRIPFIP LHRRDLVSAE EGSMTFVGPQ GERINWKKFE VLGEVILPIM
KSQSTPYPNL TKHDVARELI LDCLMPTDDE DIYQRSLAVE TSTGGGSDVG KKKFPWFAK
//