ID A0A1Y2E2B9_9FUNG Unreviewed; 3957 AA.
AC A0A1Y2E2B9;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Dynein heavy chain, cytosolic {ECO:0008006|Google:ProtNLM};
GN ORFNames=LY90DRAFT_700676 {ECO:0000313|EMBL:ORY65698.1};
OS Neocallimastix californiae.
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Neocallimastigomycetes; Neocallimastigales;
OC Neocallimastigaceae; Neocallimastix.
OX NCBI_TaxID=1754190 {ECO:0000313|EMBL:ORY65698.1, ECO:0000313|Proteomes:UP000193920};
RN [1] {ECO:0000313|EMBL:ORY65698.1, ECO:0000313|Proteomes:UP000193920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G1 {ECO:0000313|EMBL:ORY65698.1,
RC ECO:0000313|Proteomes:UP000193920};
RG DOE Joint Genome Institute;
RA Haitjema C.H., Gilmore S.P., Henske J.K., Solomon K.V., De Groot R.,
RA Kuo A., Mondo S.J., Salamov A.A., Labutti K., Zhao Z., Chiniquy J.,
RA Barry K., Brewer H.M., Purvine S.O., Wright A.T., Boxma B., Van Alen T.,
RA Hackstein J.H., Baker S.E., Grigoriev I.V., O'Malley M.A.;
RT "A Parts List for Fungal Cellulosomes Revealed by Comparative Genomics.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY65698.1}.
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DR EMBL; MCOG01000051; ORY65698.1; -; Genomic_DNA.
DR STRING; 1754190.A0A1Y2E2B9; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000193920; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF8; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000193920}.
FT DOMAIN 196..762
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 1344..1738
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1872..2198
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2355..2458
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2576..2663
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2687..2934
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2947..3073
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3106..3174
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3205..3261
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3499..3619
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3651..3748
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3751..3954
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 958..1044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1087..1138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 585..633
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2932..3025
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 967..1026
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1087..1112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3957 AA; 454917 MW; EDF11224021FADE3 CRC64;
MASKKGAPAT PTKDAEEKVV KLDPRAEWLG EQIVAQLKLK SEKWDKLVSL QENCDIIQQF
LDTSEVNTLL FILNARDDLI VTVNFPSSLK KKGAFVLKNT LNEPIAETLE NNVTIGDLAS
NPLDYLNCIL EEVYLPLLTN SRNMDAWPEV VAMDVLRHFY KVNGAVYVIS GKTKGKTLLP
LPHGNNDFSE NDKALLHTLE SAVIDWTYQI KEVIKSNSAT PLEEGLYPTP QVEIDFWEAK
EANLKCIYQQ LSDDKFQAIA DLLQSSKSTY YPAFQQIFDE VKNALEEATD INLHLTPLRP
LIETLSSTSD FNEMMQQFPP LLHVIMLIWN HSKYYNVPGR VIVILQEICN EIIDQAQNFI
QPNEIFGIES DEALEKINLV YHACTKFKSI YYEYKAKIAE TERPWNFDTK LAFSRFDQFI
LRIKQLSEFF DTIIEFNRLE KIEIGGTKGK ILSSEVVDIF NEFTSTYQDW TKIDYDVLDL
NNYQFREDLA KFQDKISDLD RRIGTIICQA FDDCSSIHSR FRLIEGFSGL LARPIIGEIF
EKKYYDLLKE YDGDLDEVNL IFLKLKNNPS IHYNMAPITG ALQWTHELKE RINSVMEKFK
ELNHKILLES EEAKLVKVKY DEIYKKLDEY EQELFKDWSD NIINDSEANL DKPLLTRSIK
DSLSLFEVNF DPKVIALLKE VKYLGSLGIQ APEKAQSVYD KDEVFRNNIF ELDHVVSQYN
NIKLTVLDVE RPLIQERVDK IDKQFEQALS VINWRSDIID DFIKSIQESV GSLLKIIQTG
KNNVVQMQNL MKKWYSSPLI ERKDSKKPLN LDDKDTKLKA IYELIQNDGK TIFNYLEDTR
KAYDVDKNDP NWRNYADYVD TVVADGFFNT IKCSLTYFLD NMDIEYLKKC ELSPILDSRI
EFIQNKLTFT PSIEEDASNS FMNIFLGILR DIYQVSVLVK RVNSQNIESE LINETAEYNE
VKSGSNNEND NKNDNETPSE ENTEGNKESS EETKATEEAT EGNTENEAKK EDSENGSRTA
ESTLDSKENE SDEDEGYLSE MLKNPELEEL KNQLISRVRD IIDDCKKYLH NRDEWMVTFL
ETPYERSIPQ EIEEENKEEK KQTDKNETEN NQNDDNEEQN ENDIVNNSSN DEEDESSMLK
LEKFEVEIHP EVIFRGWLKV DAKPLKQSLN IIVKKWSYTL TKYLSDETTK TLNEMNEFIT
NTKGGLQKEV MEGDYDALRN DIGKSFEPLR KTINLLRQFG VEMPEDIHKL LNDLPEVWDD
TKKLSQSVKE VVAPLQAKEF EMRNYNFKEE FRQKAPFMYS IGCSNAYELI NECHFEVLQM
EQECEQLRES CELFELNCPQ YKQLSECRKD INMLKTIWDY VGLVNKIDPD AMEQTCREFT
KDLRKMDKEI KAWNVYSGVD QHVKDMITSL RAVGELRSSA IRERHWKQLM KTTGVTFVMT
DDMKFKDLLS LQLHRYEDDV RNIVDRATKE LSMEKVLNDL SKTWGTMEFE YKERDRKGTY
ILISSEELVE TLEDNQVMLQ NLMTSKYVSH FEEQITGWQE KLSTVDTVMS LWLEVQKTWS
HLENIFLESE DIRQQLPEDS KRFDGIDSDY NELMKNAINT PNAIEACSKE GLNAKLEYLQ
QKLALCEKSL AEYLETKRLA FPRFYFVSAS DLLDILAKGN IPHAVAIHLQ KLFDSISKLE
FTKDENGNYT KTAIGMYSKE DEYVPFKEPL ECVGPVEVWL NHLVDTMRMT LRHLIGEAVS
TYEEKPRDQW IFDHPAQVTL TGSQIWWATE VNASFARLEE GYENSMKEYY KKQCNQLTTL
ITLIQGELSK LDRQMIMTVC TLDVHARDIV GKLVQEKAEN AQCFSWQSQL RLRWDEEKRH
CIANICDAQF TFCYEYLGDT PRLVITPLTD RCYITLTQSL HLIMGGAPAG PAGTGKTETV
KDLGRALTVM VYVFNCSEQM DYRSIGNIYK GLAQSGAWGC FDEFNRISVE VLSVVATQVK
SIEDGLRAKK KRFIFQGEEI SLEPTVGFFI TMNPGYAGRT ELPENIKALF RPCSMVVPNL
ELICEIMLMA EGFVEASILA RKFHTLYKLN KELLSKQDHY DWGLRAIKSV LVVAGSLKRS
DPGVPEEHVL MRALRDFNLP KIVTDDLQVF NGLINDLFPK IDIPRKRNLD FENDIKKSTI
ACGLQAEETF VLKVVQLEEL LAVRHCVFII GNAGSGKSEI WKMLAKTYIN NGKKCVYADL
NPKAVSTNDL FGYINPATRE WKDGLFSSIM RDMFNISGPD PKWIILDGDI DPNWIESLNT
VMDDNKVLTL ASNERIPMKP AMRLIFEIGD LKYATPATVS RAGILYVNTS DLGWNPYVQS
WLAKLEDQSE RTTLSVLFDK YVNTILDTIH SGRFKMAPVE DNSMVITLCN ILEGLIFNQT
SLKGCDKEIY EIYFVIQDQL VDYRVEFSKW WNSEFKTVKF PPVGTVFDYY IDNTTRQFAL
GQIKFQNSSI LEKPLEKKAG RNYGPPGTKK LIYFLDDLNM PEVDCYGTAS PHTLLRQHID
YNHWYDRTKL TLKDIHNCQY VACMNPTAGS FTINPRLQRH FAVFSVSFPT LEKKIVNAAL
QLHKKVSQVF LPTAIKFHYV FNMRDLSNIF QGILFSTKEA LKEPTDLIRL FLHETRRVYG
DKLLETTDME QLVNFQLLLR RKSKDWASLK KILDDALDQY NEINAAMNLV LFEDAISHIC
RINRILESPR GNALLVGVGG SGKQSLSRLA SYISSMDVFQ IVLRKGYGVA DLKLDLAALF
QKCGLKQQQI VFLLTDAQIA DESFLVLIND LLASGNVPGL FPDDETETII NAMRNEAKAQ
GLLDTRENLK VVLCFSPVGN LLRSRCRKFP AIVNCTSIDW FHEWPEEALT GVAKRFISAC
ERVPEELRDP VTKFMAYAHL SVNEVSKKYL LNEKRYNYTT PKSFLALINL YEEMLEKKHA
ELIKSMDRLE NGLTKLQSTS SQVDDLKAKL AVQEVELKQK NEEAELLIER VSVDTEKVNK
EKAIADQEEK KVDQITKEVS EKQAQCEQDL LAAEPALEAA SQALNTLNKA NLTELKSFGT
PAEDVKNVVS AVMENIDQSN LDALAPYLAD PNFNADYIRT KSFAAAETIA LANRLVNGLA
SEKVRWSDEV ANFKEQEKTL AGDVLLAAAF ISYVGCFSKS YRNELLEEKW LPYMRQTNAD
GKPFIPMSAE LDPLDILTTS AEIARWNNEE LPTDRMSLEN ATMVTKCKRW PLIIDPQLQG
IKWIKAREGD SLKVIRLGQR DIGIEIDPVL NDVLGRNTIK KVENLETTKS TSTDIEKQVK
EAKLTEKSIN ETRELYRPVA ARSSLLYFLL NDLYQIHPMY QFSLNAYKVV FQNAIHNAEP
SEDIKERVNS LIDNITYSIM ITQNEIDMNE FNFLLRAPRA PNVTSPFDWL NNQSWAVIKA
LSDLDEFKSL ANDIEVPENE KLPQEWKNKN AIQKLCILRA LRPDRMTYAV RNFIVQKMGA
KYVDSTRQPL SQTYTEMNPS TPIFFILSPG VDPVKEVELL GKQLNFTEDN GNFHNVSLGQ
GQEIIAEQKL DLAYEKGGWV MLENIHLVAK WLPTLAKKLE ALSVGAHKDF RVFLSAEPAG
NPSCHVIPTS ILQVSIKITN EPPTGMKANI HRALDNFSQE TLERCSKDIE FKTILFTLCY
FHAVVLERRK FGTQGWNRSY PFNTETFPKV PWTDLRYMFG DIMYGGHISD DWDRRLCSAY
LDVYLKEEML DGNFELAPGF SLPPPSDYKI RSLKELDLGL KGDLTISEPM ETLMNAIYLN
TVPATWERLA YPSLQSLSNW YVDLLQRIRE LENWVQEFSL PTVLWISGLF NPQSFLTAIM
QTTARKMEWP LDQNREEYNT PPREGAAICG LFMEGARWDT QTGMIQESQM KVLTPAMPVI
QVKAIPVEKK EVKGIYECPL YRTRNRGPTY IWTFNLKTKE VPQKWVLSGV CLLMSVD
//