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Database: UniProt
Entry: A0A1Y2E4A9_9PEZI
LinkDB: A0A1Y2E4A9_9PEZI
Original site: A0A1Y2E4A9_9PEZI 
ID   A0A1Y2E4A9_9PEZI        Unreviewed;       504 AA.
AC   A0A1Y2E4A9;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   31-JUL-2019, entry version 10.
DE   RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE            EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN   ORFNames=BCR38DRAFT_340164 {ECO:0000313|EMBL:ORY66362.1};
OS   Pseudomassariella vexata.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Xylariomycetidae; Xylariales; Pseudomassariaceae;
OC   Pseudomassariella.
OX   NCBI_TaxID=1141098 {ECO:0000313|EMBL:ORY66362.1, ECO:0000313|Proteomes:UP000193689};
RN   [1] {ECO:0000313|EMBL:ORY66362.1, ECO:0000313|Proteomes:UP000193689}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 129021 {ECO:0000313|EMBL:ORY66362.1,
RC   ECO:0000313|Proteomes:UP000193689};
RG   DOE Joint Genome Institute;
RA   Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA   Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA   Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A.,
RA   Culley D., Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E.,
RA   Spatafora J.W., Visel A., Grigoriev I.V.;
RT   "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|RuleBase:RU003423};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003423}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ORY66362.1}.
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DR   EMBL; MCFJ01000005; ORY66362.1; -; Genomic_DNA.
DR   OrthoDB; 854035at2759; -.
DR   Proteomes; UP000193689; Unassembled WGS sequence.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; -; 1.
DR   Gene3D; 4.10.320.10; -; 1.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR004167; PSBD.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF02817; E3_binding; 1.
DR   SUPFAM; SSF47005; SSF47005; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS51826; PSBD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:ORY66362.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000193689};
KW   Lipoyl {ECO:0000256|RuleBase:RU003423};
KW   Reference proteome {ECO:0000313|Proteomes:UP000193689};
KW   Transferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:ORY66362.1}.
FT   DOMAIN       49    124       Lipoyl-binding. {ECO:0000259|PROSITE:
FT                                PS50968}.
FT   DOMAIN      195    232       Peripheral subunit-binding (PSBD).
FT                                {ECO:0000259|PROSITE:PS51826}.
FT   REGION      152    192       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      235    256       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    159    174       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   504 AA;  55406 MW;  1ECF9073C355E37A CRC64;
     MFLQRGSRAI RRQWHLYHTL NRFVEVGIRR GAYATAARGF HSTTSLQVVK PVLLADIGEG
     IVECEIIQWF VEPEARVEEF SPLCEVQSDK ASVEITSRFS GIVKKLHYDA GEMAKVGKPF
     VDIDIQGDVK KEDLEALTVT EPEAPVEIGV AEPLNKESLS KAPESQVQEE TSGNEIPENN
     RHSKPPKQGG RFASLATPAV RHLSKAYKVD ITEIEGTGRD GRVLKEDIHR FVENRNSSSI
     SNQAGTAPPS SAFSQPVDTA TQTETTVQLT HTQAQMFRTM TRSLSIPHFL YADEIDFTNV
     CSLRRRLNKI LASSAKVEEV TKLTYLPFII KAVSVALNQY PVLNSRVDVD SQTSKPSLMM
     RSQHNIGVAM DTPSGLVVPV IKNVGSRNIL SIAAELVRLQ SLAATSRLSV QDMSGGTITV
     SNIGNIGGTY LSPVLVDKEV AILGIGRIRT VPAFDEDGNV VKKHVCNFSW SADHRVVDGA
     TMARAAEVVR QFVEQPEVMV THLR
//
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