ID A0A1Y2E767_9FUNG Unreviewed; 4637 AA.
AC A0A1Y2E767;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=LY90DRAFT_380234 {ECO:0000313|EMBL:ORY66715.1};
OS Neocallimastix californiae.
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Neocallimastigomycetes; Neocallimastigales;
OC Neocallimastigaceae; Neocallimastix.
OX NCBI_TaxID=1754190 {ECO:0000313|EMBL:ORY66715.1, ECO:0000313|Proteomes:UP000193920};
RN [1] {ECO:0000313|EMBL:ORY66715.1, ECO:0000313|Proteomes:UP000193920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G1 {ECO:0000313|EMBL:ORY66715.1,
RC ECO:0000313|Proteomes:UP000193920};
RG DOE Joint Genome Institute;
RA Haitjema C.H., Gilmore S.P., Henske J.K., Solomon K.V., De Groot R.,
RA Kuo A., Mondo S.J., Salamov A.A., Labutti K., Zhao Z., Chiniquy J.,
RA Barry K., Brewer H.M., Purvine S.O., Wright A.T., Boxma B., Van Alen T.,
RA Hackstein J.H., Baker S.E., Grigoriev I.V., O'Malley M.A.;
RT "A Parts List for Fungal Cellulosomes Revealed by Comparative Genomics.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY66715.1}.
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DR EMBL; MCOG01000050; ORY66715.1; -; Genomic_DNA.
DR STRING; 1754190.A0A1Y2E767; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000193920; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 5.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000193920}.
FT DOMAIN 1926..2068
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2222..2375
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2592..2746
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2934..3100
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1309..1336
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3196..3275
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3449..3476
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4637 AA; 536153 MW; 8D68C64DA1EC0EA9 CRC64;
MEEESASEYS SSEQLLTETI TSSEFRDYIV KLITLLLEAS EEDINTCVND ENFNPIELEN
FIKDNVIQTL FIIKEKIDDN QDGHFKYFIN FEINYSQLQV ASLALIKRFP ILQKDKPIQA
QLQIINLPGY LDGGNPYETL HSYIHNVVSP YFNAYVSSKS ENNSKVASNF EDKDVKAGIP
MTRKKITELE LSLLHLQQNV EIPEIILEIN PVVTKAIEEC KKKGDDPKVS AINYIPKSYL
TDSKFLDKLQ KEVQNWVTDI RKVADLNRDP TTGTASQEIN FWLGMESSIT SIEKQLIDVP
VLLTLEVLKN AKRYHATISF HSDTGLMERS ETVRKYAQVM KDFPINELLS ALDLEKVREA
LEKIFNHLLK KLKVTLYPTQ RSLPLVEAIS RDLNNQLMKI LSSKKLMYMP FEEFENVTNG
CDIVFNTWKE NSREFTNIAR DTVRRRKEKF ILVKIDAAHE KLQERINFIK DFRIRHEHLQ
KTIEKIIKSD SEYAGDEDSG IDSSTLDDVS EAYSNFKNID ILDVSTDGTD AWNNAENLYN
EKIEKVENQI IVRLRSRLEK AKNANEMFRA FSKFNALFFS QKIRNAILEY QTPLIDSTKN
DIKKLHEKFI AKYPQSQVSV VCQARDIPPI AGNISWAKQI DNQLDMYMKR VEDVLGKGWE
KYTEGEKLKK ESDAFKIKLD TRPMFDAWIA KMTSDQNNIL ITTGKVFVIK SYNDISGGDK
LLDTKASKKY VLDVNYDPQT ITFYKEIRQL IWLKFNVPYT LIRYSKEAKR IYPYAVSLKE
TVKIYYHTGR KVDENHEIIS LIAIFKKKVQ DVIVKGANLC WENFIDIDQT QRGFENSNNK
QIKFVKEFYN VVSIFQDKVD EAILINDEVN HIIDEMKICD YDKEIFYDYL DKIQKFIDKL
NLESYSNLNQ WVSQLDARIE AVLIQRLENA IKSWINAFQT ENPEISEIAI ARKKRNRLSS
ASNLGLTRSE MEVIDKDEPQ KNTPEFPLLI HELKIKNQLM YLDPPIENAR AEWYYQFQDW
LSSICSLKHI QGSRYDMNID DNDNVEVSTY INLLTKLSGN LLEQAYEVIE NRIKKVNKYL
SIWLRYQSLW DLEPDYIYNQ LKDDLSLWKQ IVLEIKKARS TFDNSETEKT FGNLVIDYAH
VQSKVNAKYD SWQRDVQNKF GTKLLARMKE FYSKISKARY NLEQYSAETS STAEAVSFIT
FVQDLKKNMP GWTQDIELFK SGQKILEKQR YQFPNDWLHI ENIEGEWGAF NEILVRKNNT
IQEQLAGLQQ KIVAEDSSLE QKIKETITEW EKTKPVHGDI KPDTAVNKLN IFEGRLERLK
ESYDQITRAK EALSLEYVVD DRLTPLIEEL HDLKSVWIAL SKIWGQLDEI KDTLWNSVVP
RKIRQSIDQL INSTKELPTR MRQYAAYEYL QDTLKGYLKV HQIFTDLKSE AIRERHWKQL
LKELNCDSKI RLSELTVGNV WDFDLHRNET IIRGVIEMAQ GEMALEEFLK QVRETWTNYA
LELINYQNKC RLIKGFQDLF TKCSENINSL IAMKHSPYFK VFEEEALSWE EKLNRIHVLF
DVWIDVQRQW VYLEGIFTGS ADIKQLLPVE TTRFQNINTE FMTVMKKVYK SPFVLDILAI
PNIQKSLERL AELLSKIQKA LGEYLERERS SFPRFYFVGD EDLLEIIGNS KDVVRIQKHF
KKMFAGIASI ILNDDATEIL GMVSKEGEIV NFSTPVSIKD NPRINDWLTL LEKEMKYSLA
YWLLESVKTI REIYFSDNIE LPKLLEWVEK YPAQLVVLSM QIIWTQSVEN ALENIENNVD
SDSLQNSFKL VERTLNILAD TVLTDLTPIT RKKCEHLITE LVHQRDLIRQ LMNHNVKSPK
DFEWLYQMRF YYNETEEPLL RLCIQMANAR FYYGYEYLGV AERLVQTPLT DRCYLTLTQA
LDSRMGGSPF GPAGTGKTES VKALGLQLGR FVLVFCCDEN FDFQAMGRIF IGLCQVGAWG
CFDEFNRLAE RILSAVSQQI QSIQIGLRTE ESIDIVGKNI KVNSNTGIFI TMNPGYAGRS
NLPDNLKKLF RNIAMTRPDR ELIAQVMLFS QGFRSAELLS SKVVPLFNLC LEQLSPQSHY
DFGLRSLKSV LVSAGNLKRT KIQEIISKEN SSPEEIEALS DAHAEQEILI QSIRETIVPK
LVVEDIPLLT SLLMDVFPGI EYSPINLENL CVAIKEICEE NQYEASDIWL EKVIQLYQIQ
NIHHGLMMVG PSGSGKTSAW QVLLKALEKL EGVEGVSYVI NPKAISKDSL YGFLDQTTRE
WTDGLFTHIL RKIIDNVRGE SEKRHWIIFD GDVDPEWVEN LNSVLDDNKL LTLPNGERLS
LPRNVRIMFE VDSLKYATLA TVSRCGMIWF SEDILTLQMI FNNYLNTLRT KELDKVEEDV
SVRDRNNANV GSISTIETQK QCAEILKNFF KEDDLVEKCL NYSYKLEHIM DFTRIRVLNT
LFSLINSIIG NIIQYNNLHP DFPLDAEQLE TYISKKLLVA IIWSFTGDAK LEARVELSQF
IQNSCTIELP TISSSLSIAD YDVDIKNGNW ISLETRVPTI EIEPHTVSTA DVVIPTIDTV
KHEDVIYSWL SEHKPLILCG PPGSGKTMTL FSALRKLPDM EVVGLNFSSA TTPELILKTF
EQYCEYRKTP NGVVLCPTMI GRWLVIFCDE INLPAADKYG TQRVLSFIRQ LIESGGFWRT
TDQAWVKLER IQFVGACNPP TDPGRVLMSH RFLRHAPLVM VNYPGELSLK QIYGTFSRAA
LKVVPSLRGY AEPLTNAMVE FFLKSQQRFT PDIQAHYIYS PRELTRWIRG IYEAIKSFDD
LSVEGLIRVW AHEALRLFQD RLVTDEEKLW TDTNINEVAM KHFPNCDHQK ALERPILFSN
WLSKNYVSVS REELREFVKA RLKVFYEEEL DVPLVLFNDV LDHVLRIDRV FRQMQGHMLL
IGVSGSGKTT LSRFVAWMNG LSVFQIKVHN KYSGEDFDED LRTVLRRAGC KDEKICFIMD
ESNVLDSGFL ERMNTLLANA EVPGLFEGDE YASLMTQCKE GSQKEGLMLD SGEELYKWFT
GKVMKNLHVI FTMNPPEEGL ASRAATSPAL FNRCVLDWFG DWSDQAFFQV GTEFTNILDL
DLSSYSPPAD FPIAYQNLPL PPTHRNAIIN AFVYVHQSLY AMNAKVSKRQ GKLNYVTPRH
YLDFINHYVR LFQEKREDLE DQQRHLNIGL DRLKDTVNKV EELRKSLAIQ KTELETKNTL
ANEKLQKMLA DQQEAMEKQK TSLEIQEDLK KKEKEIEERR AIVMADLAKA EPAVIEAQKS
VSNIKKQQLT EVRAMGNPPD AVKMAMESVC TLLNHKITDW KSVQSVIRRD DFISSIVNFD
TKKLTPQMRD HIRHNYMSNP KFNFDTVNRA SKACGPLVKW VIAQTSYSDI LERVGPLRRE
VQQLEETAES TKVKADEIIK VINELEVSIA ARKQEYAVLI SEIEKIKAEM ERNEIKVNRS
IKLIENLSSE KERWQTSSET FEVQMSTIVG DVLLSSAFLA YAGYFDQQYR EQLFNKWSSH
LDKAGIKYKT DLSLSEYLST ADDRLAWQSN ELPVDDLCTE NAIMLKRFNR YPLIIDPSGQ
ATQFLMNEYK DRKITVTSFL DDAFLKNLES ALRFGNPLLV QDVEHLDPIL NAVLNKELRR
AGGRVLIRLG GQDIDFSPSF TLFLSTRDPS VNFSPDICSR VTFVNFTITR ASLQSQCLHQ
VLKAEKPEVD QKRNDLLKLQ GEFQLKLRHL EKSLLKALNE SKGNILDDDN VITTLETLKQ
EAAEITRKVE ETDTIMMEVE SVTNMYAPLA QSCSAIYFSM EQLNQLHHFY QFSLDFFFEI
FEYVLHNNPH LKNKTDSFER LNILYSDLFD VSYERTSHAL LHEDHITLAI LLVQIKLRGS
SDQLNDDEFE FLISGGNSNP TLEHYSSEVA NIVGKEVANR LCSYFELPFF EKINDHIINS
KEDWEKFMND GYAENFIPVF WDNSEHLSIQ SEFRKLLVIK CFRPDRLIAA TNQFINIAFG
ENFNLYSEVN LKSIVFDETN CNTPIAFCSV PGYDVSNRIE KFAQSSNNKL VSLAMGSAEG
FSLAEQAITN ASKRGTWVLL KNVHLAPQWL SQLEKRMHSI KPNPSFRLFL TMETNPKVPI
NLLRMSRVLM FEPPPGIKAN LQETLRNIAT NHNFDGPAER SRLHFLLAWL HAVVQERLRY
APLGWTKTYE FNDSDQESAL DTIDFWINEA SQGRSNIAPN LIPWDAIRTL IKETVYGGKI
DNEFDQYLLD SFVNYLFTPK CYELDFPLVK FEDGTALTIP EGTKVEQFME WVNKLPEQQP
TWLGLPSHAE KLLLAIKGNN MLSKVRQMKS ITDDEVVYTQ DEVENENENN LQPSWMKTLN
NVVSNWLTVL PEKLSSMIHN ENSVQDPLFR FFNRENSIAQ KLLNKLHQDL KNIKLICEGK
MQQTNYLRKL MDTLNKGLIP NEWRQYKVCK DMSINQWIND FARRVKHLEE ISQKSEFENI
PVWIGGLFIP EAYITATRQA SAHKNHWSLE ELELELSIDT NDNDGFNLIN LTLEGGSFEN
GMLQISSKTV TEIPSIQLKW IKKGEELHTN YITLPVYLNE DRTDLLFRAK FDTSEDQKQN
IIQHSVALIS SNNRLAI
//
