ID A0A1Y2EIB5_9PEZI Unreviewed; 3872 AA.
AC A0A1Y2EIB5;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Polyketide synthase 3 {ECO:0000313|EMBL:ORY71044.1};
GN ORFNames=BCR38DRAFT_479572 {ECO:0000313|EMBL:ORY71044.1};
OS Pseudomassariella vexata.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Pseudomassariaceae; Pseudomassariella.
OX NCBI_TaxID=1141098 {ECO:0000313|EMBL:ORY71044.1, ECO:0000313|Proteomes:UP000193689};
RN [1] {ECO:0000313|EMBL:ORY71044.1, ECO:0000313|Proteomes:UP000193689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 129021 {ECO:0000313|EMBL:ORY71044.1,
RC ECO:0000313|Proteomes:UP000193689};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY71044.1}.
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DR EMBL; MCFJ01000001; ORY71044.1; -; Genomic_DNA.
DR STRING; 1141098.A0A1Y2EIB5; -.
DR InParanoid; A0A1Y2EIB5; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000193689; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19532; C_PKS-NRPS; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR013595; Pept_S33_TAP-like_C.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF20; HYBRID PKS-NRPS SYNTHETASE APDA; 1.
DR Pfam; PF08386; Abhydrolase_4; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF13489; Methyltransf_23; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000193689};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2..434
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2384..2461
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2468..2520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3125..3144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3872 AA; 424756 MW; 7CE89A5AD814F559 CRC64;
MYEPLAIVGT ACRFPGAAKS PSRLWDLLKA PRDVLKEFPP ERLNTANFYH NNGDMHGRTN
VEHKSYLLDE DVRHFDAAFF HLNPKEAADM DPQQRILLET VYEAFEAAGW SLSDVDGSQT
SVHVGSMTED YTSIQSRDPD MSGSHVATGV SRAILSNRIS YAFNLQGASL SLDTACSSSL
VALHLAAQGL HRGEATQAVV AGTNLLMDPF WYIAESSMHL LSTDSRCRMW DKDASGYARG
EGCAAVVLKT LAQAVRDGDH IECVIRGSLV NSDGATNGIT MPSPAAQSAL IQQTYRNAGL
DPITDRCQYF ECHGTGTQAG DPVESQAIRD TFFPDNKHED DSILYCGSIK TIIGHLEGCA
GLAGVIKASL AIQNKAIPPN MHFNQLNPKV EPFYKNLEVP TSLMPWPEIH DAPRRASVNS
FGFGGTNAHA ILESYEPSET IVSSLNSSTS EIMDDSVYQS MVGGRIGGPF VFSARSRTSL
VNWLKQLLTY LRENQSLDLD SLSSSLYSKR TAFPYRVAIP AASDLDDLVQ KLEDQINTIS
TSMDGSGAGA GFAAPKSLRI LGIFTGQGAQ AARMGCALLE HCKLFKESII ACEEALKCIP
EPPPWSLSEE LAADATKSRV SEAKFSQPLC TAIQIGLVDL LRACGIKFSA VVGHSSGDIG
AAYAAGLLTR KDAMGISYYR GHVAHLARGD AGESGGMMAA AMPFDAASAL CSEPRFKNRI
NVAASNSPSS VTLSGAKDAI VEMKEHLDRI NIQARALQVD VAYHSHHMLA CADAYLGHLK
QLDIRIQTPP TDQECHWYSS VRANTNILER PFESGLEAQY WVDNMVQPVL FSEAVKLAVQ
VVSARFSAAM EIGPHPALKG PVNQTFKQSI DYTPQYTSCL SRGNDDIETF SEMLAMIWTI
DPSSIDFASW RKAFGLAAQP QVLKNLPPYA WDHTQIHWRE SRVVRNYRLG KQPPHDLLGR
LWNDAQYEHT WRNIFQLKEM PWVKGHVFQG QVLFPATGYI SLAVDAAKAF ITGRPIKLVE
VLDMAIPTAL VIGEGDEVEV LFTIRSRVSP EKVEDGSILE AEFACYSYPD GREADKTCDG
RLLVHLGEPE PEDLAPTNIS NVELTPFNVD RFYRAASDIG FGYDGTFRAL TSLNRCWGHA
KAVASWPKDD LDVCCTLHPA ILDVALQAGL ATFVSTAERS MPSSYLPVGI KRALVHPNVD
FLSLDGSTNI EIEAYMTSPE LGKLMEADIN VRAKKGTRDD LGGIQLEGVR FKAISEPQPS
EDRNIFAKTV WGLDAAYGLV QPRTAEISAR SSMYTPEEYE RVALFYLQSL ARSVNARELN
VVKHHHQDLM RFIDATVAQL RKADHPVLMR EWLNDSSDTI KHLLSRDPSD VDMAMLASSA
EWTLTLLEGT SEYTHESLPS SFYHNRSSAT TCNEYIAQLV LQISHQFPRT NILEISAGVR
NTTSTILGTV GDAYAHYTCA GASETVIKSL KEKLVPAETE NVSFKVFEVE ADLASQGFEA
GSYDIVIATD VLRASRYLSR TVQNMRRLIR PGGFLIAMEF TGTSLRPTAI MGGLETWWAG
VSDRGTASPV ITTGEWDKLL ERHGFSGIDC TLHDQANVGM HGFSVFSSQA TDDRLDILRD
PLISMDMITP PPVILIGGET SKVSRLVRQA EKMVRGWATE IQAYSRFDQI DCSRIPPGAS
VISFQDLDKP LFSSPPSPSE LRNLKQVLDI SRNILWVTSR RMADDPYANI MIGIGRSLRL
ESPDTTIHYL DFDEDEPWDI QVLMAQFLRL IFSSSLGVAE GMLWVEEPEI VIKDSQILVP
RILPDQISNE VYNAKRRQIT KLVEPAEPIE IAKDVDSADS VLICSRSLDL PENHVPIQVK
LSVALHDGNE SPCFLCYGNV KDQGDRVVLT LSETDSSVAH VREDSDFSSL GLQECDAEDL
ANLASFLIAS HVVSNIPGHG TTLVCGASDR LADAIRLVVA GAGCKALFVA ISKERQSEHD
GWLYVHPQST ARSFQQMIPR GPINLYGLSK KNTDTISRWL PAGCTSVEDA VRVYSTHQES
LASASKPAIV NIHELPQPRD SSPVRLSVVT NWKRESSVGA ILRGLEPSAL LSPDKTYFLV
GMASELGQSL TYFMIRAGAR HIVLSSRNPK GGQNWIHDLQ AIGIEIRVVK MDVTSRSQVR
ETVAMLRRTM PEIGGVTNAA LVLEPAIFAN LSAESIAKQM KPKIYGTANL DDEFKTSKLD
FFLTFGSLST VCGNAGHAIY HAGNAFMMSL VQNRRRRGLA ASILNFGMLV DVGYVARSDR
SAGPSVEEWL RTDLPTALSE ADFHHVILQG IAAGHPNSPS GEVIMGLEMF HDQGQSSKPR
WANAPLFSHM VRVSKASKDG QADDAPSSIQ RWQQNLEDAI SFDEAIPPIT ELLSRKIESM
IHVSLHSIHP DEPMSHLGID SINAIEIRKW LREKLEADIS MLKILGRDSI SSIIRTVAEQ
YIAKRPATKS MSKGEISTAE VPQPNKTLAP KADPNAQKES TGPTLSNHGH DARDSEASLT
SSQCLTGISN QIPGPQLPFI RSERLSYAQA GFFYLSAFSD SRTSFNLTGR FRIKGRLDTE
RFCRAFDQVM HHHEALRTCF LATSGSSEVM QHVTKNATPQ ISRLQSTKET AKVDVEKAFD
EIAKHEYSLA TGDTLRATLI SHGAQWHTLV IGFHNIALDA VSMRLLFADI DRAYRFQTLS
QDSASYLDFT RQEIDDVQAG RLDESIDYWK RLLDPIPEPI PLLPTAKVKT RQNRRSYGYH
LVKRELSSEL VQRVTQISQA HGVTPMQFYL AVMRVFLCRL LDIDDICIGV MSHGRDPTSR
FGDTVGHMAN ILPIRFKGSW GECFPEVLEN TFKTLLDSFD NRNVPFAVVL EKIQALRSEG
GMPLVQVAYD YRVGENVANS VGGCTMELEE TIYTTLYDLT IDVLQSTSHG HLLNIRCSDD
FYSLSTTEFI AETFVNVIES LAPDPSVAVK DIGLFSDTQL QQATTVAHGA DVEHSWPQSL
SERFEQVVAN FPGSVAVKDG NEAITYNQLK QLVEIYANIL LEAKTTAGSL IAVLCEPSID
LYATMLAVFH IGAVFIPLDV SVPAARRNDM MKACQPDLLV FHAATAASAT EDHGEYRSLN
IAEKARAHPR HARSPERTVS DPGSDSYILF TSGSTGVPKG IKLHQRGMMN YAAYTSKAYG
FKQVRVLQQT SIGFDLSFAQ IYNAFTNGGT LVVASVEARG DPDMLSRFII DEMIEYTIGT
PSEYNLLLSY ASDVLQQCRS WRFCHTAGEA LPERLIEGVR ELKLPNLTLT DAYGPAEAFI
VTNRNIQVHA GAIQDECNNR AGSVGYVLPN TSVYITSESD GSLLPLGVPG EICIAGSGLF
NGYLDTELGD EKFVENPFAS AEYLEQGFHT MYKSGDRGIL HADGSIVFLG RCFGYNAMIK
LRGLRIDLNE VTGAILGAAP NDLADAAVTV RGDPQFLIIN ITGASTIEPA RGSILINFGG
PGGDGQQNLA ATAEFLQNMT GGFHDIISFD PRLFAQIPNT ATANSSDTAL GHIWAEAMLS
SDACLNGMNE SGTLVGTAFV ARDMMKIVDA LGEDGMLRYY VLGATVASMF PDRMDRVLLD
GVVNPDDYYH GPDTVTFTDT DKTFRSFLSG CVTAGDACAL AHRNQTPAEL ESSIHDFLQI
LKYEPIPVAG LVLDYSIFKA TLLGSLYWPS GWPQLAAALD SMLSNDIDTL AQHLDYLVTP
AASIQYEALP GIKCSDKFPR LSSSKALVPI MEEFYEISEW CGETVANLVS QCAQWQFDAK
ERYDGDFQVQ TRNPVLLVGN TFDPVTPLAA AQNVSAGFDG SVVLQHNGNG HSSWAQRSAC
TMKAIADYFV NGTLPEPGTV CEVDAPLFSE TE
//