ID   A0A1Y2EX24_9FUNG        Unreviewed;       918 AA.
AC   A0A1Y2EX24;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Ras GEF {ECO:0000313|EMBL:ORY76133.1};
GN   ORFNames=LY90DRAFT_665642 {ECO:0000313|EMBL:ORY76133.1};
OS   Neocallimastix californiae.
OC   Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC   Chytridiomycota incertae sedis; Neocallimastigomycetes; Neocallimastigales;
OC   Neocallimastigaceae; Neocallimastix.
OX   NCBI_TaxID=1754190 {ECO:0000313|EMBL:ORY76133.1, ECO:0000313|Proteomes:UP000193920};
RN   [1] {ECO:0000313|EMBL:ORY76133.1, ECO:0000313|Proteomes:UP000193920}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G1 {ECO:0000313|EMBL:ORY76133.1,
RC   ECO:0000313|Proteomes:UP000193920};
RG   DOE Joint Genome Institute;
RA   Haitjema C.H., Gilmore S.P., Henske J.K., Solomon K.V., De Groot R.,
RA   Kuo A., Mondo S.J., Salamov A.A., Labutti K., Zhao Z., Chiniquy J.,
RA   Barry K., Brewer H.M., Purvine S.O., Wright A.T., Boxma B., Van Alen T.,
RA   Hackstein J.H., Baker S.E., Grigoriev I.V., O'Malley M.A.;
RT   "A Parts List for Fungal Cellulosomes Revealed by Comparative Genomics.";
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ORY76133.1}.
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DR   EMBL; MCOG01000023; ORY76133.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y2EX24; -.
DR   STRING; 1754190.A0A1Y2EX24; -.
DR   OrthoDB; 68574at2759; -.
DR   Proteomes; UP000193920; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF160; RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR C; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000193920}.
FT   DOMAIN          510..640
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          677..914
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          120..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..140
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   918 AA;  106104 MW;  E8C464FE2EF3A64A CRC64;
     MTDILQQSVK SQSTQNNKSN QKLVRVNFPD QSTTVIQIGE HETCWDVLCK VCEKKSLKPG
     LFSLAMSSPE VTHTTLKRRS TSSNKPTIDK SILMDAEKIF FSYNCNTIFL IENIDENDCG
     SRSSSRRSST MIAPSSRKTT VRLDSQTFPK TVEITEVQEG DNISLNSEKS KSDFSLKRGS
     KMFGFFLKGH KKNGSDSSSM LCVSPTQSAS VSRQQSGIND FENNEFSLYN KNSNLVITEN
     VPLEDDLFKQ NANIIERNSK NDILKKSLSD LGSGILKESK EDLTYYNKVN ENLNSKIRDE
     LTPITVNFTP EMDPLINNLK SYMTEPMTAS VIPDHPTNKV EEEDGVTDLP QSNTTIKPRA
     RRRACTVSLG TTGRLVTSTL RSSKISARRP VSGLFEGTFN DVNDLNRILI TFTLPDGTTT
     NKKYNLDSTI DNVCDTICIE NKLEPNKYSL ILSEKTDYNL EFDRTLGYYK DLNIPIEKFH
     IIAQSSAKHY STMTICENDV DVMVFQMSKE GLQVMAGTVP KLIEHLTDNS ENNTDFLDTL
     LLTYRSFISP VDLFNELVAR FNCLPPDNPT EDDLIYYDKM KLPVQQRVIK TLRWWVHYHW
     QDFSFNYQLS TNLKSFLKQL QDYSEENKTD VFKEDTDDIT NIMNTELKAY EEKWEHFKTL
     HENKSRNLKD SIIEKFDEET ITKHLCLHDF ELFKNIHPIE YLNLIWKTKK YDCGDEEEDN
     TPNLDYFITR FDKESYWVAT EICHVPDLKK RSQMLKKWII IANTCIKYNN FFSFFSIVAG
     LNLTPVSRLK KTWDGLSDKY KKMWNDIEKI CDPSRNMKNY RDILTKSKPP IVPFLPIYLK
     DLTFMNDGNE SKVNGMINFD KLRMMAKRVK DISKLVDYEY KNFQVDIVLQ NYISHLMVEP
     LDKLKKDSLE IEPKVQKK
//