ID A0A1Y2FGD2_PROLT Unreviewed; 785 AA.
AC A0A1Y2FGD2;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Muts domain V-domain-containing protein {ECO:0000313|EMBL:ORY82474.1};
GN ORFNames=BCR37DRAFT_311033 {ECO:0000313|EMBL:ORY82474.1};
OS Protomyces lactucae-debilis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Taphrinomycetes;
OC Taphrinales; Protomycetaceae; Protomyces.
OX NCBI_TaxID=2754530 {ECO:0000313|EMBL:ORY82474.1, ECO:0000313|Proteomes:UP000193685};
RN [1] {ECO:0000313|EMBL:ORY82474.1, ECO:0000313|Proteomes:UP000193685}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=12-1054 {ECO:0000313|EMBL:ORY82474.1,
RC ECO:0000313|Proteomes:UP000193685};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY82474.1}.
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DR EMBL; MCFI01000009; ORY82474.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2FGD2; -.
DR STRING; 56484.A0A1Y2FGD2; -.
DR OMA; KMTMLYK; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000193685; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF21; MUTS PROTEIN HOMOLOG 4; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000193685}.
FT DOMAIN 194..521
FT /note="DNA mismatch repair protein MutS core"
FT /evidence="ECO:0000259|SMART:SM00533"
FT DOMAIN 537..724
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|SMART:SM00534"
SQ SEQUENCE 785 AA; 86270 MW; FC5708814CA7F0EB CRC64;
MDTTARPPTV RSRPRTAGHA SNSVCALVES RGISRLVGMA FFLLDSGTCI LTEVADTFIR
TIHKLCVLEP TQILAPATAF SPTKSKLVRI IEENTPNNNL RAISRRLFSE AEGLEYLSDY
CIDQDITAVK TATSGKFFCI AAFAAGIKHL EDEHNTVFAP KTLRIQYQSS DGVMLMDWGT
VRSLELISNS IEAKSDRSLL GILKKTGTAA GHRLLRSSIL QPLTNKDIIE HRLELVKEFT
EKETLFFDVQ KAVKGQHDLE RLLAVLVTKP AQVSMKFSEQ RLNDVLLLKS ALQLVFSIAT
AMSRAESALG IEIAALLSAA AKDDVLAAIS ELITEDTEVA SSPLALRNQR CYAVKAGING
MLDLARQTYK ELVDDAVSLA TQYAEEYELP IQLQFEANRG FFLSIPIGQT DHHEPLPDTF
VNQVKRKKTI QFSTLDLAKR NARIHEALNE LLMLSDEAVE ELVETIQTHI SGLYKLSEAI
ALLDMLHAFA SVAISSRYVR PHFSDDTLGI KQGKHPVKEK LEGLHYVAND TFANVNSRFQ
IVTGCNMAGK TTYLKANALL VVMSQIGSFV PAAHVATPIF EQLCTRFATD DGTDVDASTF
SAEMQDMAFI MREAKASSLV LIDELGRGTS TSDSLAIATA ICEKLLVSKA TVLFATHLHE
LAQVLQWRPG VTCLRLRVSE EADRLTMHYQ VADGTCQQSA YGLKLAQSTA LPSTLTDRAV
GLRTALLVRQ ADRRAASKIG KIVARRKAVL ELQLSLMRSA ESVLAEKDTH ALLLRLQSAF
LDNLA
//
