ID A0A1Y2FK96_9FUNG Unreviewed; 975 AA.
AC A0A1Y2FK96;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=CNH-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LY90DRAFT_395810 {ECO:0000313|EMBL:ORY83987.1};
OS Neocallimastix californiae.
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Neocallimastigomycetes; Neocallimastigales;
OC Neocallimastigaceae; Neocallimastix.
OX NCBI_TaxID=1754190 {ECO:0000313|EMBL:ORY83987.1, ECO:0000313|Proteomes:UP000193920};
RN [1] {ECO:0000313|EMBL:ORY83987.1, ECO:0000313|Proteomes:UP000193920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G1 {ECO:0000313|EMBL:ORY83987.1,
RC ECO:0000313|Proteomes:UP000193920};
RG DOE Joint Genome Institute;
RA Haitjema C.H., Gilmore S.P., Henske J.K., Solomon K.V., De Groot R.,
RA Kuo A., Mondo S.J., Salamov A.A., Labutti K., Zhao Z., Chiniquy J.,
RA Barry K., Brewer H.M., Purvine S.O., Wright A.T., Boxma B., Van Alen T.,
RA Hackstein J.H., Baker S.E., Grigoriev I.V., O'Malley M.A.;
RT "A Parts List for Fungal Cellulosomes Revealed by Comparative Genomics.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY83987.1}.
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DR EMBL; MCOG01000006; ORY83987.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2FK96; -.
DR STRING; 1754190.A0A1Y2FK96; -.
DR OrthoDB; 5100844at2759; -.
DR Proteomes; UP000193920; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00821; PH; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000193920}.
FT DOMAIN 318..500
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 539..646
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 662..952
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 975 AA; 110485 MW; 0C975F1F1EEF0015 CRC64;
MESIPQLITQ PIIEQNPAPT PALVPDQKQN QTQISVPTIV IPARTSASIH PKSSTGTPPS
TTATESNDDS SKTLTKSDST TTNNSNGSTE IVTEEEIEEL GIINHSALLS EIAEEFINSI
PLLKKVMDSI EYTESFSGTD AVNTIADLIG TSNRKLALAI GRSLESQLLF HDVLYTNELF
DSDDIIYQLN ARSSMRYNRD SRLDISAIIG DYIETSGIYS EDNDITLDVN SNNNSIHSHT
DLPSGVFVAI SSCYSPTCTN DSPCYSYSCP RRKAYNLKSS TSKDSKPKHS NTLKSNENAW
STTVGKNVLE KVDDHERKRQ EVIYEFIQSE KEYVDDLMAL IKRPLSEGIV PKIDNGFVNV
VFSNIEEIFG CNAPFSQTLQ NMQQKNSIID RLGDITMEFV KSFTCYIRYG EIQPLAKEVL
QYHKNTNSAL ENFLKQMQSK KEFRRLPLES FLARPTTRLG RYPILIKDIL KHTKEDHPDQ
KTLKSTMEII QNILKQVNEK AGKTTDRLKL DQWAKSLDQT TMEKVEDILT LRLNSPQRQF
LREGQLLLKR DGTTPQEVDI VFLDNAFVIT RKKVNTVEIL KKPIPVQLIK LIDHEIEDKN
NNKNLPFNEK KYTFSVVHMG YRSYTFIAKV FSEKKSWIET IEERVKQVQG SYIELFNIYS
CHLKINTAVV VKDDIMIFAN ENGLFTNVGN TLSLILPLQR ITTIDIMPDA GLLFVLIDKE
VIPYSIDALL RGSLVNNSKK PRKLCSGISF MEIGFCYDHH LLCAVKTANT NSTIKSYEPN
QPLIDSITAG KIKKSLSTID VLIPHKQFYI PAEAKSIQFL KRALCVGCTK GFEVVDITTF
TTQSLFDTHN PEYEWIIKAE YNPIKLIKTS KGDFIVCYNK VGFFLDKNGN PSRGNTRFFW
LNSATTFSYI SPYILAISNN YVEVWDENDP DSVKQIIYGY NIRLFTDYTG DAVYIISGSD
MQLISRIILS RKRTI
//
