ID   A0A1Y2GSF8_9FUNG        Unreviewed;       762 AA.
AC   A0A1Y2GSF8;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE            EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN   ORFNames=BCR41DRAFT_421462 {ECO:0000313|EMBL:ORZ19290.1};
OS   Lobosporangium transversale.
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mortierellomycotina;
OC   Mortierellomycetes; Mortierellales; Mortierellaceae; Lobosporangium.
OX   NCBI_TaxID=64571 {ECO:0000313|EMBL:ORZ19290.1, ECO:0000313|Proteomes:UP000193648};
RN   [1] {ECO:0000313|EMBL:ORZ19290.1, ECO:0000313|Proteomes:UP000193648}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 3116 {ECO:0000313|EMBL:ORZ19290.1,
RC   ECO:0000313|Proteomes:UP000193648};
RG   DOE Joint Genome Institute;
RA   Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA   Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA   Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA   Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA   Visel A., Grigoriev I.V.;
RT   "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC         methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC         ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001709};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ORZ19290.1}.
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DR   EMBL; MCFF01000014; ORZ19290.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y2GSF8; -.
DR   STRING; 64571.A0A1Y2GSF8; -.
DR   InParanoid; A0A1Y2GSF8; -.
DR   OrthoDB; 1359537at2759; -.
DR   Proteomes; UP000193648; Unassembled WGS sequence.
DR   GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR045004; ECH_dom.
DR   InterPro; IPR032259; HIBYL-CoA-H.
DR   PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR   Pfam; PF16113; ECH_2; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000193648}.
FT   DOMAIN          393..544
FT                   /note="Enoyl-CoA hydratase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF16113"
FT   REGION          656..685
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          701..739
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        657..672
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        714..733
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   762 AA;  84454 MW;  4C023AAD993CE73C CRC64;
     MATDLEKYTE QATLPFSSSE LGAFHRFHAY NWDGDEHFQA GLRTITQAQP LPPSLSELLK
     MKQYYFSTRL GTHINLDNYL SWRKHLEKPS DDPNVLIFKR FDEYDFDNDP RFQSGLPNIV
     SQLVKDGKST LDKAALQKEM TKAKAFYYAR FIELFDFPAY LNWKELEKSQ DGPACPFAHL
     WQNKSEGSSS ELAEDAQKFL TTTAPVSTGA LQIHIHSPAT KNVWTGVRLA KMNQAISDAN
     DKDTITSILL TANSGAPTQD RRDPESLIVT KDEKWFSGGL VTSGSTEMQD KQDPAKFKEL
     QRQYFSVVDQ LTAINCHHHK PVVCVADGIV SLSAAYLAFG SGGQRVITEN ATLSFTPLKA
     IELPPNEALN PFAGLHLLAQ IQTHAKSDSG ARSLPKNIGH YLAFCPDNIL RGPDLRKLGL
     ADFFISSSKK NDIEKAVLSV AGCPPPHTVQ AIRMALNAEV VYPGPPKIDV WRSEIKECFD
     DAASLDDVVT KLEKYNNNWS KSIREYIASL EPVFAKLLFE AITKASEMAS FQERARLEYR
     LNVRYKDYLL SKDTTAEDDI KDLQVFFEPI EEEESELFTF PFTEWIKEHG NENEFTNTVK
     TNGNSIEEQD ATQACPYLRS KTDGDRHTAM PSDHPTIITG AELNDPEAVK TCPFLSAKKS
     GQDSTASNST GVGVPDDHPK IPGVDFSDAK AAEACPFLAA KKAQDDDEKK DLQPVTATTS
     PTTVTTAVSS TVPNDHPVIP GVDFSNPAAM ASCPFLASQK TK
//