ID A0A1Y2ID43_PYCCO Unreviewed; 1106 AA.
AC A0A1Y2ID43;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 08-NOV-2023, entry version 23.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=PYCCODRAFT_1416510 {ECO:0000313|EMBL:OSC99045.1};
OS Trametes coccinea BRFM310.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Polyporaceae; Trametes.
OX NCBI_TaxID=1353009 {ECO:0000313|EMBL:OSC99045.1, ECO:0000313|Proteomes:UP000193067};
RN [1] {ECO:0000313|EMBL:OSC99045.1, ECO:0000313|Proteomes:UP000193067}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BRFM310 {ECO:0000313|EMBL:OSC99045.1,
RC ECO:0000313|Proteomes:UP000193067};
RX PubMed=26692083; DOI=10.1186/s13068-015-0407-8;
RA Couturier M., Navarro D., Chevret D., Henrissat B., Piumi F.,
RA Ruiz-Duenas F.J., Martinez A.T., Grigoriev I.V., Riley R., Lipzen A.,
RA Berrin J.G., Master E.R., Rosso M.N.;
RT "Enhanced degradation of softwood versus hardwood by the white-rot fungus
RT Pycnoporus coccineus.";
RL Biotechnol. Biofuels 8:216-216(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KZ084131; OSC99045.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2ID43; -.
DR STRING; 1353009.A0A1Y2ID43; -.
DR OrthoDB; 51419at2759; -.
DR Proteomes; UP000193067; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR024729; USP7_ICP0-binding_dom.
DR InterPro; IPR029346; USP_C.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF644; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE K02C4.3-RELATED; 1.
DR Pfam; PF00917; MATH; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF14533; USP7_C2; 1.
DR Pfam; PF12436; USP7_ICP0_bdg; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000193067};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 47..179
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT DOMAIN 205..524
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
SQ SEQUENCE 1106 AA; 128108 MW; 4BA3BBA7DAD80CF9 CRC64;
MSDTMDALDE KVNGGPPMEV EEIVSVHDHE AFAAKHMPDL GHEVKDFKVF TWRLTNWKKL
EKKLTSPEFE CGGHRWRILL FPFGNSNAPP NDTVSVYLDY ADPKRAPEGW HACAQFALVI
SNIHDPTIYT VSHAHHRFIA EECDWGFTRF SELRKLFSVQ DGHTRPTIED ESADVSVFVR
VLEDPTGVLW HNFVNYDSKK ETGYVGLKNQ GATCYMNSLL QSLFCTRYFR KAVYQIPTED
DHPTESVPLA LQRVFYHLQT SDQPVGTTEL TKSFGWKSLD SFLQHDVQEF NRVLQDKLES
KMKGTKAEGA IQKLFVGKMK SYIKCVNVDF ESSRIEEFND IQLNVKGMKN LYESFKDYVA
VETLDGENKY MAEGYGLQEA KKGIIFQSFP PVLHLQLKRF EYDIQRDAMV KINDRHEFPF
EIDLGEFLDE TADRSQPWVY KLHGVLVHSG DLHGGHYFAL IKPDRETRWL KFDDDRVTPV
TDREVLEENY GGEVMTNGFP PMQRNQVRAM KRFTNAYMLV YIRESAIDEV LAPWKDEDTP
AHLKRRLEEE RLQMEAKKRE REEQHLYLTA KVITDQTFAD HEGFDLASFD ERNWPATDLP
SFRVLKNEPY STFKSRVAQH FNYPENQIRL WVLVNRQNKT VRPDTHIPEN EPQLTVEAIR
NTMAVRQQND LRLYLDIIPD PSHPEIPPGS IMIFLKHFDI ANQRLTGVGK VYVPRSSKVS
DLIPIINERM RWTPDTPLKL YEEIKPGMIE LMKPKLTFTQ SEIQDGDIIC FQVDMNEKEL
HDFEAQGMYS NPVQYYDFLQ NRVMILFKPK FEETDAEHPE FHLTLSKKQN YDVMSAKVGE
RLNWDPIKLR FTTTHSNGTP KQVLKRSLNQ SIQEIMQPAY VSPQTTVILY EKLDVSIVEL
ETKRSLKVIW TGIHNKEEST HPFLLPKTSS VHDLAVELSK QVKLTPGGTG KIRFFEVSKD
GKSQKEFTYS EMIGNIPDPV ELYAEEIPRE ELEADDADKV INVFHFSKEV SRTHGVPFRF
VVKPNEKFSE TKKRLQARIG VSDKDFAKYR FALIQHATFK QPSYIEDEDT IYDHKFAPED
VLGLDHVDKS GKTRTGAGEK AIVIRG
//