ID A0A1Y2LIL9_EPING Unreviewed; 5874 AA.
AC A0A1Y2LIL9;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=B5807_11703 {ECO:0000313|EMBL:OSS43873.1};
OS Epicoccum nigrum (Soil fungus) (Epicoccum purpurascens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Didymellaceae; Epicoccum.
OX NCBI_TaxID=105696 {ECO:0000313|EMBL:OSS43873.1, ECO:0000313|Proteomes:UP000193240};
RN [1] {ECO:0000313|EMBL:OSS43873.1, ECO:0000313|Proteomes:UP000193240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ICMP 19927 {ECO:0000313|EMBL:OSS43873.1,
RC ECO:0000313|Proteomes:UP000193240};
RA Fokin M., Fleetwood D., Weir B.S., Villas-Boas S.G.;
RT "Genome sequence of the saprophytic ascomycete Epicoccum nigrum ICMP 19927
RT strain isolated from New Zealand.";
RL Genome Announc. 0:0-0(2017).
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
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DR EMBL; KZ107861; OSS43873.1; -; Genomic_DNA.
DR STRING; 105696.A0A1Y2LIL9; -.
DR InParanoid; A0A1Y2LIL9; -.
DR OMA; WISVHGG; -.
DR OrthoDB; 2787863at2759; -.
DR Proteomes; UP000193240; Unassembled WGS sequence.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd05918; A_NRPS_SidN3_like; 3.
DR CDD; cd19542; CT_NRPS-like; 1.
DR CDD; cd19545; FUM14_C_NRPS-like; 2.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 6.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 4.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR041698; Methyltransf_25.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 4.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR PANTHER; PTHR45527:SF16; NONRIBOSOMAL PEPTIDE SYNTHETASE ASQK; 1.
DR Pfam; PF00501; AMP-binding; 6.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF08241; Methyltransf_11; 1.
DR Pfam; PF13649; Methyltransf_25; 1.
DR Pfam; PF00550; PP-binding; 4.
DR SMART; SM00823; PKS_PP; 4.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 5.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 9.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR PROSITE; PS00455; AMP_BINDING; 4.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000193240}.
FT DOMAIN 1704..1780
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2761..2837
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4276..4352
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5361..5437
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1195..1221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3769..3796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1205..1221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5874 AA; 645109 MW; BCEB3D3848794B99 CRC64;
MIPQTRLFKG DETQKMWHQN GDVPQSVERC VHDLFVEQAA AQPDAPAICA WDGELTYGEL
HALSTKLAVH LVGLGVKAES IVPLCFEKSM WTVVAMLAVL KAGGAFVPLD PDHPQIRNKE
ILQQTAATIL LTSARYSTLW ENSTYDVVSI DKPTIDELAV KPLEDHRTAE PNNAVYVMFT
SGSTGKPKGV VLEHRTVTTN CFGHGKAFGL SPRTRALQFA SYTFDVCITE IITTLMFGGC
VCIPSESDRR NDLAKAINAM NINWALLTPT TARVLDPSSV FTLETLVLGG EQVVRSDWKR
WNGYVQVINT YGPTECSVWC TCYVGVPNSE SGLIGKPFAS VCWVVDADDH NKLAPTGLVG
ELLIEGPILA RGYLNDAKKT EEAFIKNPTW LTQGVGGYPG RQGRLYKTGD LVQYSSDGNL
VYIGRKDGQV KVRGQRLKLG EVEHHLRDFS VWQRQQTQVD EHDRQLKYWV AQLQTSRPAE
LLCDKPRPAT LSGSADVHTL KVDGLLYVKL QDFCNARGVT LFVVLLAAFR ATHFRLTGQE
DATIGTANAN RDRSELKDMV GFFANMQCLR ITVGGETFEE LVQQVQAVAV ASLANQDVPF
ERIVSKLKKD RDLSRHPLVQ LVFAVHSQRD LGKLTLEGVE TEGVGDTATS RFDLEFHFFQ
ESNRLRGDVI FSTDLYAPET IDNMLSLFRN VLEACLKEPE AVVASMALVT EADYAQLDRM
GLIRVEETGY PRQSSIVDVF RQQASTHPSR IAVKDASAEM SYAQLDAASD VLAQWLRRRS
LAPETLIGVF AGRSCQTIVA FLGILKANLA YLPFDVKIPT GRMEAILSSL PGEDQRVVLV
GADEQPPDVK LRNVEFVRIA EALDEQANEE SGLQEPVAAA ARPSATSLAY VMFTSGSTGQ
PKGVMVEHRG IVRLVRDNNL VQHLPESRVM AHMSSLAFDA STWEIYACLL NGGTLICIDA
ETVLNPELVL QMFTRHKIRT AAIATALVRQ YFAARPAIIA LLDMLCVGGE VLLPRDFFAL
GNLLKHKLVN CYGPTENVVN STIFHFTKDE KCINGVPIGR ALSNSGAYVM DSELRLVPLG
VVGELVVTGD GLARGYTDPK RDVGRFVSVT IAGQTVRAYR TGDYVRYRPT DGHLEYFGRM
DGQVKIRGQR VELGEIEHVL RSHKCVSDAV IVLQQHEGDE VRLAGFVTVD EGVAAVDEQP
DDGDGNNSGG GSGNKDESQH VGTWGEKFSN DIYSLVSNVQ KERIGRDFIG WTSMYDGSEI
DKAEMNEWLD DTINTITTML NNGKSGSVLE IGSGTGMILF NLGDGLQSYV GLDPSRKAVE
FVAEVAQTMP AMADKIRLHK ATAEDVGRLE QPVAAELVVL NSVVQYFPSQ EYLFKVIEEL
LKVAGVQTIF FGDIRSYALH REFLATRALH IAGDKATKAD MRRMVSDMER VERELLVDPA
FFTALPSRLP ELVEHVEILP KKMKATNELS CYRYAAVVHV RSQHGQKQEV QHVGHDEWID
FSERKLDRQS LQQQLTSLSS LPTIAVSNIP YSKTIVSRCL VELLDNADAD AGAPDAPGWL
TSVYQQAKHQ PSLSATDLVE LAQESGCRVE ISWSRQYSQR GGLDAIFHRY PPRNGENRIL
FRFPTDHADR PLHGLSSRPL RQQFLKKTQQ QLLEMLEAQL PAYMVPQAIT VLDAMPVTQN
GKVDRKALEQ RTQAERSSRT PVQQSLSEAE RRMQQLWAQV LGITADSIGL DDSFFRLGGD
SIAAMKLVGE ARKQGMQLSV ADLFRHPKLA ALASLDINSS DITAEEEEIA AFSLLGADAD
ATQVRKEVAA SCGVDADLVE DVYPCSPLQE GLVSLTAKRA GDYIMQSVLE LGSGIDEGVF
RAAWEHVIRS TAILRTRVVQ HSELGLLQAV VAEDMRWTEA EGLEEYLDKD KSVSMGLGDP
LARYAVVKEE QEGGDAKRWF VWTAHHALYD GWSLPRIMDA VAKAYSGGEV EQQKQPSFQS
FIKHLAQQDP DEAATYWQAA LADCEATLFP VLPSAVQQPV ADASIHYQCA PLPKTASDMT
TSTLIRAAWA ILASRYTGSD DVVFGAVVTG RNAPVAGIEA VVGPTIATVP VRVQVRKDQT
AAAFLSSVQQ QATEMIPYEQ TGLQRIAGMG AGAQHACGFQ TLLVVQPANN SLAGDSALGE
WRGGLKLQGF TTYGLTVQCM LAAEGAGIAV TASFNERIVE RWLVEKMLSQ FSYMMQQLAR
VGPETMLAGI DALTPKDRQE LWTCNGEVPA AVERCVHDLF AEQAQARPDA PAICAWDGEL
TYGELDALST KLAGHLVELG VKAEDIVPLC FEKSMWTVVA MLAVLKAGGA FVPLDPDHPR
SRHEEVLKQT QAGLVLTSAQ HVSLWADSAL QVVTVSDAFL CQLLPDTGHI QPLSRPGNAA
YTIFTSGSTS IPKGVVLEHQ AVSTSCLSHG VAFGFTQHTR ALQFASYTFD ACITEIITTL
LFGGSRLLDP ASVTTLKNLV LGGEQVRAAD WERWVGHVKL TNGYGPAECC VSCAAYSGGK
GGFKSGLIGK PIASVSWVVD ASNHEQLEPV GAVGELLVEG PILARSYLND AEKTRAAFIS
DPTWLVEGGD GCPGRRGRLY KTGDLVRYDA DGNLVYMGRK DDQVKVRGQR IELGEVEHHL
RACMPEIQQL AVEVVLPTGE GANATLAAFL QLENGLQGTP STNGLDNTRL LAQVLFLRDV
EEEMLRRLPK HMVPTVYFAV GQLPTMTSDK MDRRRLREIG ASFSAQQLAE LRTASDGAKR
APSTEAERMM QQLWAGVLGV SADSIGLDDS FFRLGGDSIA AMKLVGEARR HGMQLSVADL
FRHPRLDQSA AVAVSSSHGS STAIPRANYQ GPVEQSFAQG RLWFLEQLHP GLTWYLMPFA
VRIKGPLQLA ALNSALLAVE HRHETLRTTF ATINGTSVQD VKPFCPRDAK VINVPRNDEQ
GLASIVQQDQ TQPFDLRTEP GWRVSIYRLN ENNHVLSIVM HHIVSDGWSA DVLMRELGAF
YSAAVRGEDP LSQVQPLPVQ YRDFSVWQRQ QAQVDEYDKQ LKYWLAQLQT SRPAELLCDK
PRPAALSGSA DVRTLKVDGL LYVKLKEFCN ARGVTLFVVL LAAFRATHFR LTGQEDATIG
TANANRDRSE LKDMVGFFVN MQCLRITVGG ETFEELVQQV QAVAVASLAN QDVPFERIVS
KLKKDRDLSR HPLVQLVFAV HSQQDLGKLT LEGVETEGVG DTATSRFDLE FHFFQESNRL
RGDVIFSTDL YAPETIDNML SLFRNVLEAC LKEPEAAVAS MALVTEADYA QLDRMGLIQV
EETGYPRQSS IVDVFRQQAS AHPSRIAVKD ASAEMSYAQL DAASDVLAQW LRRRSLAPET
LVGVFASRSC QTIVAFLGIL KANLAYLPFD VKIPAGRMEA ILSSLPGEDQ RVIFVGADEQ
PPDVKLRNVE FIRIVEALDE QANEESGLQE PVAAAARPSA TSLAYVMFTS GSTGQPKGVM
VEHRGIVRLV RDNSLVQRLP TSPIMAHVAN LAFDGSTWEI YACLLNGGTL VCIESMVVLD
PDAILQHFYM HKVQTAFLTT ALFKTYATEV PALLATLDMF CVGGEAMHWQ DLSVLHSDIV
RKMIHVYGPT ENTTFSTIFI QQKDHIYTNG VPIGRALSNS GAYVMDSELQ LVPLGVVGEL
VVTGDGLARG YTDPQRNAGR FVSVTIGGQT VKAYRTGDYV RYRPVDGQLE FFGRMDGQVK
IRGQRVELGE IEHVLRNHSS VRDAVTVLHQ HDGDEVRLAS FVTIDKGAAA VDKQPDDGDG
NDSSGGSGGK DESQHVGTWE EKFDNDIYSP VSNVQKERVG RDFIGWTSMY DGSEIDKAEM
NEWLDDTLST MLNGGKPGSV LEIGSGTGMI LFNLGDGLQS YVGLDPSRKA VEFVTEAAKT
MPAMAGKIRL HKATAEDMSR LEQPVAAELV VLNSVVQYFP SQEYLFKVIE ELLRVAGVQT
IFFGDIRSYA LHREFLAARA LHVAGDKATK ADIRRIVTDM ERVERELLVD PAFFTALPSR
LPELVEHVEI LPKKMKATNE LSCYRYAAVV HVRSQHGQKQ EVQHVGHDEW IDFSERKLDR
QSLQQQLTSL SSLPTIAVSN IPYSKTIVSR CLVELLDNAD ADAGAPDAPG WLASVYQRAQ
HQPSLSATDL VELAQESGCR VEISWNRQYS QRGGLDAIFH RYPLRNGENR ILFRFPTDHA
DRPLHSLSSR PLRQQFLKKT QQQLLEMLEA QLPGYMVPQA ITVLDAMPVT QNGKVDRKAL
EQRIQAKRSS RALVQQSLSE AERTMQQLWA QVLSIAPDSI GLDDSFFRLG GDSIAAMKLV
GEARKQGMQL SVADLFRHPK LAALASLDIN SSDITAQEEE IAAFSLLGAD ADATQVRKEV
AAGCGVDADL VEDVYPCSPL QEGLVSLTAK RAGDYIMQSV LKLRNDVDEG ALRAAWEHVI
RSTAILRTRI VQHSELGLLQ AVVTEDIEWR QADKLETYLK QDKGASMALG DPLARYAVVK
EEQEGGEKKW WFVWTVHHAL YDGWSLPRIM DAVEKAYGGT EIQKQPGFQA FIKHLGQQDP
DEAAAYWQTA LADCEATPFP ALPAAVQQPV AEATVHYQCP ALPKTASDMT TSTLIRAAWA
ILASRYTSSD DVVFGAVVTG RNAPVAGIEM IAGPTIATVP VRLRIERDQT VLAFLEGVQK
QATEMIPHEQ TGLQRIAKMG PDARHACGFQ TLLAVQPVDD SFAGGSALGE WRGGSELQGF
TTYGLMVQCT LVSEGVGITA SFDERIVERW LVERMLGQLG FVMQQLATAE HETTTVGSID
TLTPGDKQQL WEWNAEVPAA VERCVHELFA EQAQARPDAP AICAWDGELT YGELDALSTK
LAGHLVELGV KAEDIVPLCF EKSMWTVVAM LAVLKAGGAF VPLDPDHPQN RHEEILRQTK
ASLVLTSAQH VSLWADLALE VVTVSEAFLR QLLLDTGHIQ PSSRPGNAAY IIFTSGSTGM
PKGVVLAHNA LSTSCLSHAK VLAFTSQTRC LQFAAYTFDA CVAETLTTLV CGGVVCVPSE
DDRRNNLTSA INNMNVNWMF LTPQVARTIS PKEVPSVEAL ALGGEWVDHT DWARWTGHAK
MTTVYGPTEC CIFSNALAFP LENKSGNIGK SIASVSWVVD AGNHDQLVPV GSVGELLVEG
PILARGYLND ADKTRAAFVE DPAWLLEGGG GCTGRHGRLY KTGDLVCYDP DGNLVYVGRK
DDQVKVRGQR VELGEVEHHL RACMPEAKRV AVEVILPTGK GASTMLAAFL QLDDKAQGKP
SANGSGESDF LARVVFLREV EEKMLKGLPG HMVPAVYFAV TELPMTVSDK TDRKRLREIG
ASFSAQQLAE LRTASDGAKR VPSTEAERTM QQLWAGVLGV SADSIGLDDS FFRLGGDSIA
AMKLVGEARR HGFRLSSAYV FRHPTLTQMS LAGVTSLNGS PQSVAPFSLL LPTIKDGILR
QSVLLESSIQ QQDVADILPT THVQRVYINR GIESPREAFN YFFFDIGPEL DAQLLRDSCR
RLLNRFPILR SQFIFFREKL WQVVLLRPQL PFSRFEINGS LSEATRRICI EDINKTDPLG
LPTSFMLYDG VCIPVIFRTL AALYMQESLP IVPSFPTYLA YARTQREAST RYWRELLEGS
HITRATARLR PKVGEEPALL NIKVEKVIAA PQLPHNITMA SLLSSAWALV LSSITGEEDV
VYGHTVAGRN SDIPGIAEMV GPCLNVVPVR VRIQSAETPA DLIRSVHEQH ASLGEADLAQ
LDEIIHDCTD WPAGSKFDTM VQHQNIDEHP EVCFAGETTR LQWFDNPFAI AQQLYFFSLP
QAGQLKLTVG GNTRLLTVEA AHSILEVLAA TVAKLSRNID GPLSSCRFSF PLCI
//
