ID A0A1Y2LMB1_EPING Unreviewed; 4333 AA.
AC A0A1Y2LMB1;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=B5807_09274 {ECO:0000313|EMBL:OSS45113.1};
OS Epicoccum nigrum (Soil fungus) (Epicoccum purpurascens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Didymellaceae; Epicoccum.
OX NCBI_TaxID=105696 {ECO:0000313|EMBL:OSS45113.1, ECO:0000313|Proteomes:UP000193240};
RN [1] {ECO:0000313|EMBL:OSS45113.1, ECO:0000313|Proteomes:UP000193240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ICMP 19927 {ECO:0000313|EMBL:OSS45113.1,
RC ECO:0000313|Proteomes:UP000193240};
RA Fokin M., Fleetwood D., Weir B.S., Villas-Boas S.G.;
RT "Genome sequence of the saprophytic ascomycete Epicoccum nigrum ICMP 19927
RT strain isolated from New Zealand.";
RL Genome Announc. 0:0-0(2017).
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; KZ107855; OSS45113.1; -; Genomic_DNA.
DR STRING; 105696.A0A1Y2LMB1; -.
DR InParanoid; A0A1Y2LMB1; -.
DR OMA; NERQMTR; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000193240; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000193240}.
FT DOMAIN 1924..2062
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2216..2445
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2581..2731
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2923..3089
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 966..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1165..1192
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3171..3271
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3397..3452
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 189..203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..984
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4333 AA; 492714 MW; BEFAA2413588B58E CRC64;
MEGPLSPGDA NAVPRAPSPT PPTIDPQIIV DYLEKVLEVN LGAIERDLHA PGSLLSDDKR
TNTLQRCAQF SKENQLVLYV VKERSPEASI VGLEGTDGVS HHYTYSVSNE LTASPHCAAF
VVLQKRPIPI DSSIPLSEQV TISTLPGFIL SNNTSSQDGA PFEFIHSLIQ TAVEPYFDSY
NKTKSQRNPK ELYNSKGDSD SRTGISAAKK KLAELALAMQ HLSDNADIPD LLLPFHPQII
LALQEAEGRG VRPSPDLISS SIVSDSTFLN QLQGTVNGWI KSIQSITKTS RDVATGTAQQ
EINFWLSMET RLQDIESQLS SAGVRLTLEV LKNAKRFQAT VSFSADTGLK EKTEQVQKYN
SLMREFPLDQ LHTSTSLVAI DEAINQIFNH LNKKLRICPY PISRALPLVE AISGDLDVEL
HKKLSGRALM NMDYPEFQAI MNVAEKIWRT WEEDVKEFTN VAREVTRRRN EKFIPIKIKP
RHRETEERIR YVTTFRKNHK QLADTIGNVL GTQSESVDGS QPKEIFIEEI GDVDAVKEVK
EAYDVLKDVD VLDVSPEGTR LFEQAEMKYN ERTSRVENSI IARLRDRLGT AKTAREMFRV
FSKFNPLFVR PKIRGAIHEY QTQLIESVKQ DIQALHERFK RQYANSEAHA MAQLRDFPPV
SGAVIWARQI EIQLDKYMGK VEDILGADWV LHAEGQKLQA ESQMFRKKLD TRPIFQTWLT
VVARNKLSIS GRLFHVSRNR AAGNILELNV NFDGQVIALF KEVRNLTWRG YQIPHGINNI
SKEAKRVYPY AVSLMESVRT YTQTVRSISE LAGVAILLNN YANDAQQLIQ KGVPLKWESF
VHAYDLHVRQ PGFPAGAGSV RSESKHVQFV RDFSAKTSLL QTKVATLVNI NAVVDKALKE
LETCPYNKGI FQQSLEIIQK SVDQLNLENY ANLATWVSDM NARIESILLV RLQYAISQWI
DAFKHGSEDE DDQRPSHDSA DGDVNEIRPT LSELTLEVTM RNQVIYLSPP VEYARASWLE
QLQQWLAVVC TLQKIKASRY EIRLETTKDV STHQFSDLPS KCTDTLIEVY STVEGRLGDI
SSYVDEWLQF QSLWDLQSDQ VYDVLGEDLS RWLQLLQEIR KTRTTFDNSD TSKSFGYVTV
DYEQVQVKVN AKYDQWQQEI LAKFANRLGQ RMNEVYAEVA KAREDLEMQT LEASSTAQAV
SFITTVHQCK QKVADWEPEI ETFRQGSATL KRQRYQFPQN WLPIEHIDHE WETLTEVLAR
KTKIADDQAD ALRAKIAAED KIVTQKISDV ISEWTVEKPV AGDLSPEKAS AILVKFDKRI
EQLTKESSNL SKAKETLGLP SSSLAVLNDL YDEVADFKQV WTNISTIWLS LGDLREELWT
SIQPRKLKKI LDDRSNDLKA MPAKLRQYQA FDHVQNTLKQ LLAENKILDE LRGEHIRERH
WVKIFKQLRP QKRYSPISMT LGDVWDLKLG PSEKIIRDVI SQAVQENVLE VFIKEVKSTW
NEYELDMIYY KDKCKLIKGW DELFAQCSEH LNGLQQMRHS PYFKEFEEEA TSWEDKLNRV
HVLFDVWIDV QRQWVYLEGV FTGNADIKHL LPTESSRFNN INSEFLTVMK KVARQNTVME
ALNIPSVQQS LDRLADMLSK IQKALGEYLE RERVAFPRFY FVGDEDLLEI IGNSGDVLRI
AKHLRKMFAG ISGLLTDEDG LITGFTSKEG EEVKLRQKIS LIQTPRINEW LGALETNMKT
TLAELTFEAF EEFAQLMAAE TMNASAFTDY ISKYPAQVVV LGTQIAWTQA VEASLNAEGK
TLPALFEKQV NVLKLLAAAV LGDLEPIHRR KCEDLITEFV HQRDVIGRLD KVKAQSTTHH
MWLLSMRYVF EPGNELLQRL RIKMANAVLD YGFEYLGVTD RLVRTPLTDR CFLTLTQAMC
QRLGGSPYGP AGTGKTESVK ALGVQLGRFT LVFCCDDTFD FQAMGRIFLG LCQVGAWGCF
DEFNRLEERI LSAVSQQIQN IQLGLKKGAE DDNAQIELIG RQLKVNSNTG VFITMNPGYA
GRSNLPDNLK KLFRSIAMSK PDKELIAEVM LYSQGFSQAK ELSKYVVPFF DSCASSLSKQ
AHYDFGLRAL KSVLVSSGGL KRARIAVIDS ATADEAVMEP QIILQSLRET IAPKLIRSDV
EIMRSIEEEA FPGVQYIPAP LEKLTGAIRE QAANSKLVVS ESWMTKILQL YQIQNLHHGV
MMVGSSGSGK SAAWRTLLSA LQKADGVEGV CHVIDPKVMS KEQLYGTLDN TTREWTDGLF
TGILRKIVDN LRGEDSKRHW IVFDGDVDPE WVENLNSVLD DNKLLTLPNG ERLNLPSNVR
IMFEVETLKY ATLATVSRCG MVWFSDDTVN VDMMIDNYIQ NLKTTAFEDV EDDSVAPGQM
TQQTLTTQAM VADFLKVKLT QDRFIEKALS MARKFNHIME FTDIRALNTL FSLLNKACRN
VIEYNIQHQD FPLEDDKMEA YLSKKLLVAV VWALVGDCPL TDRKQFGDLV AGMTDVALPP
LNDSTSLIDY DAKPEKSDWD MWQNQVPNVE VNTHSVVQTD VVIPTLDTVR HEDVLYSWLA
EHKPLLLCGP PGSGKTMTLF SALRKLPHMQ TVGLNFSSAT TPDLLIKTFE QYCEYKKTVN
GVQLSPTQIG RWLIIFCDEI NLPAPDKYGT QRAISFLRQL VEHNGFWRTS DKTWVTLDRI
QFVGACNPPT DAGRTPMGLR FLRHAPLVMV DYPGEQSLLQ IYGTFTSAVL KIIPTLRGFS
DALTKSMVQL YSESQKRFTP DIQPHYVYSP RELTRWVRGI YEALRPLETL SVEGLIRIWA
HEALRLFQDR LIGEDERIWT EESVHRIAMQ HFPNIDEDKA LGGPILYSNW LSKNYMPVER
EHLRDFVKAR LRTFCEEEVD VPLILFNDVL EHVLRIDRVF RQPQGHLILI GVSGSGKTTL
SRFVAWMNGL SVYQIKVHGK YTGDDFDEDL RNVLRRCGCK GEKICFILDE ANVLDSGFLE
RMNTLLANAE VPGLFEGDEY ATLMTSIREG ASRQGMNLDS QEELYKWFTE QIVKNLHVVF
TMNPPEEGLS SKAATSPALF NRCVLNWFGD WSDQALFQVG SELTQSVDLD RPKYIAPDSI
PIAYQGLNLP PSHRESVVNA MVAVHHSLRS KNEKLQRTQN RKMYLTPRHY LDFVAQYVKL
YNEKREDLEE QQRHLNVGLE KLRETFDKVR DLRASLAQKK TQLEQKNSEA QQKLQQMVAD
QRQAEEKKAG AKILEAQLAE ERTAIQERSE EVNRDLDQAE PAVLEAQKSV QNIKRQHLTE
VRSMGNPPAG VKLALEAVCT LLGHKPDSWK TIQGIVRRDD FIASIVAFDN EKQMTPQLRL
KMNKEYLSKE DFTFEKVNRA SKACGPLVQW VAAQVMYSEI LNRVEPLRKE VAELEQKLYE
TEQGAQETQE LIGKLDRNIK RYEEDYAILI SETQAIKTEM STVQFKVDRS VRLLDSLSSE
QVRWEESSKS FDSQIDTIVG DVLVAAAFIA YSGYYDQQYR KALSEDWYDQ LKNSGITFKT
PNPITEYLST ADDRLTWQRN GLPVDDLCTE NAIVLQRFNR YPLIIDPSGR TTEFLQNECK
GQRLTVTSFL DDSFVKQLES SLRFGNPILI QDAEYLDPIL NHVLNKEYQK TGGRTLIQLG
KQEIDFSPTF RMYLSTRDPS ANFAPDICSR TTFVNFTVTQ SSLQTQTLNE VLKSERPDVD
ERRSNLIKMQ GEFAVHLRQL EKRLLQALNE SRGNILDDDR VIETLETLKK EAKEISDKVS
ETAGVMTEVD NITKEYTVVA RSCSAIFAVL EQLHHLNHFY QFSLQYFTQI FETVLQKVRN
GSDTNHATRI DQIITELFVD AYRRTSLSLL QKDRVTFAML LVQAAPYKMD KTLIDRILDV
DMQAIDLSTQ PERKEEALQR ASKLSIFKDE IDKIDDEAFL TEELAERFVP EAWPGDLNKF
DKQLRALILV KLFRVDRFVP AVERFVTQVF GKGILDASGD LGHIVKQVTA ITPVALSSSP
GFDASYKVDN LVERERVSCA NIAMGSNEGA STADKAIANA ATTGNWVLVK NVHLAPQWLQ
SLEKRLEALK PNPDFRLFLS MESSPKIPVN LLRASRVLSY EQPAGIRANM KDSLSSLAEK
AVKPPVEKAR VYLILSFLHA VVQERLRYAP TLGWKGFWEF NDSDYECCSY IIDTWIDTVA
QGRSNIAPSK IPWEMITTLI TEMYGGKIDN ESDWQTLASI VRDCMTPAAF EDNFKIVKDT
DVSEGLELPS TTGWKDFMKW VNDLPEREPP TYLGLPANAE KLLLVGQAKE MVGNLKKVVD
MLDEGEQIMA EAE
//
