ID   A0A1Y2MDR8_EPING        Unreviewed;       362 AA.
AC   A0A1Y2MDR8;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN   ORFNames=B5807_01701 {ECO:0000313|EMBL:OSS54230.1};
OS   Epicoccum nigrum (Soil fungus) (Epicoccum purpurascens).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Didymellaceae; Epicoccum.
OX   NCBI_TaxID=105696 {ECO:0000313|EMBL:OSS54230.1, ECO:0000313|Proteomes:UP000193240};
RN   [1] {ECO:0000313|EMBL:OSS54230.1, ECO:0000313|Proteomes:UP000193240}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ICMP 19927 {ECO:0000313|EMBL:OSS54230.1,
RC   ECO:0000313|Proteomes:UP000193240};
RA   Fokin M., Fleetwood D., Weir B.S., Villas-Boas S.G.;
RT   "Genome sequence of the saprophytic ascomycete Epicoccum nigrum ICMP 19927
RT   strain isolated from New Zealand.";
RL   Genome Announc. 0:0-0(2017).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004406}.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KZ107838; OSS54230.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y2MDR8; -.
DR   STRING; 105696.A0A1Y2MDR8; -.
DR   InParanoid; A0A1Y2MDR8; -.
DR   OMA; GDHFKRG; -.
DR   OrthoDB; 1133at2759; -.
DR   Proteomes; UP000193240; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000193240}.
FT   DOMAIN          9..274
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   362 AA;  39160 MW;  F8F01982799FC695 CRC64;
     MPTARIPILI TGGCGFLGTE IVSALLSSSR YAITVIDINP PALGTSTFTQ HVRYVRCNVL
     DLPSLESVLA ETAPAVVVHT VGVYRLGAAR YSMVGKEAEF QVNVEGTRNV VESAKKCGAR
     GLVYTSSVTV VLDEMGVDFR NVDERWPTGR ATTSYGQSKT LAEDIVLASN TPTFSTCSLR
     LSPILGPYDP TVIPTLYSCI SQFQTPFILG TSTTALQDYI YVSNAADAHV LAVHNLLGPQ
     TAAGEAFFVT NGQPLPLRHI CLAVWKEFGH APPFELQIPE NMAWVLGAVA EAGAWLTGSE
     TALSRGVVDD ACRQRYVSIT KARAVLGYKP RVSLEEGIRR SCEWYKGVLG SRQVRKERGG
     WS
//