ID A0A1Y2MYY2_PSEAH Unreviewed; 472 AA.
AC A0A1Y2MYY2;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Malate dehydrogenase {ECO:0000313|EMBL:OSY40047.1};
DE EC=1.1.1.37 {ECO:0000313|EMBL:OSY40047.1};
GN Name=mdh_2 {ECO:0000313|EMBL:OSY40047.1};
GN ORFNames=BG845_02870 {ECO:0000313|EMBL:OSY40047.1};
OS Pseudonocardia autotrophica (Amycolata autotrophica) (Nocardia
OS autotrophica).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Pseudonocardia.
OX NCBI_TaxID=2074 {ECO:0000313|EMBL:OSY40047.1, ECO:0000313|Proteomes:UP000194360};
RN [1] {ECO:0000313|EMBL:OSY40047.1, ECO:0000313|Proteomes:UP000194360}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 535 {ECO:0000313|EMBL:OSY40047.1,
RC ECO:0000313|Proteomes:UP000194360};
RA Grumaz C., Vainshtein Y., Kirstahler P., Sohn K.;
RT "Pseudonocardia autotrophica DSM535, a candidate organism with high
RT potential of specific P450 cytochromes.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OSY40047.1}.
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DR EMBL; MIGB01000014; OSY40047.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2MYY2; -.
DR STRING; 2074.BG845_02870; -.
DR OrthoDB; 9802969at2; -.
DR Proteomes; UP000194360; Unassembled WGS sequence.
DR GO; GO:0030060; F:L-malate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001557; L-lactate/malate_DH.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR001236; Lactate/malate_DH_N.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43128; L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)); 1.
DR PANTHER; PTHR43128:SF34; L-LACTATE DEHYDROGENASE; 1.
DR Pfam; PF02866; Ldh_1_C; 1.
DR Pfam; PF00056; Ldh_1_N; 1.
DR PRINTS; PR00086; LLDHDRGNASE.
DR SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:OSY40047.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000194360}.
FT DOMAIN 165..304
FT /note="Lactate/malate dehydrogenase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00056"
FT DOMAIN 309..467
FT /note="Lactate/malate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02866"
FT REGION 29..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..64
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..132
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 472 AA; 46436 MW; BE80FA2A8FF3D800 CRC64;
MTVHGAASVD AAAGGTLYVR PGDIVTPLAR ERARELGTEI VTGPPPPAAA TGTGPPPAPT
PGSATAPGGT PATVPGRGAL PGRGALPGRD PASGATPGTA SGAGRAERSA GPAPAPVAPV
PGGPPPPVRP PSGALFRRGA PLPGAVRPGA AGARPTGRGS AASGRVVVVG AGNVGMIAAM
RLADADVFDE VVLVDIDEGR AAGIALDLTH TAALSGFGTR VRGAGTVAEA GPADYVIITA
GKPRTPGMSR SDLISTNAAI VGDVARRAAA VSPQAVIVVV TNPLDEMTQH AWTASGLPSG
RVLGMAGVLD TARFQALASL TGVARADRIQ AWALGSHGEE MVIPLSTATT GGRPLSAAIP
AAELDAVVSR ARGSGGEVVG LLRSGSAFMA PGMSAARMVL AMAADSGEVM PAAVLGDGSY
GISEVYVGLP ARLGRNGLRE IVTLDLLPDE LSALRAAADR IRERVAELAT AA
//
