ID A0A1Y2N9B9_PSEAH Unreviewed; 361 AA.
AC A0A1Y2N9B9;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN Name=echA8_1 {ECO:0000313|EMBL:OSY44064.1};
GN ORFNames=BG845_00184 {ECO:0000313|EMBL:OSY44064.1};
OS Pseudonocardia autotrophica (Amycolata autotrophica) (Nocardia
OS autotrophica).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Pseudonocardia.
OX NCBI_TaxID=2074 {ECO:0000313|EMBL:OSY44064.1, ECO:0000313|Proteomes:UP000194360};
RN [1] {ECO:0000313|EMBL:OSY44064.1, ECO:0000313|Proteomes:UP000194360}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 535 {ECO:0000313|EMBL:OSY44064.1,
RC ECO:0000313|Proteomes:UP000194360};
RA Grumaz C., Vainshtein Y., Kirstahler P., Sohn K.;
RT "Pseudonocardia autotrophica DSM535, a candidate organism with high
RT potential of specific P450 cytochromes.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OSY44064.1}.
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DR EMBL; MIGB01000001; OSY44064.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2N9B9; -.
DR STRING; 2074.BG845_00184; -.
DR OrthoDB; 9790967at2; -.
DR Proteomes; UP000194360; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:UniProtKB-EC.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lyase {ECO:0000313|EMBL:OSY44064.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000194360}.
FT DOMAIN 17..345
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 361 AA; 38296 MW; 1C7B50C887719EF5 CRC64;
MSSGPTNDVR VERTGGIGRI VLDRPKAINA LTHEMVLTID ATLRAWATDD GVGAVVLTGA
GERGLCAGGD IRGIHADAQV GGAATRDFWR DEYHLNALIG RYPKPYVAVM DGLVMGGGVG
VSGHASHRIV TERTRLGMPE VGIGLVPDVG GTWLLSRASG ELGLYAALTG AVLGAGDALA
MGFADWYLPT GKLPALMSAL ADLRVPAAEL PEALGGLLQD LAEPEPEPEL SAYRWWIDRC
FEAPTAEEIV HRLATSGVSE AEDTAKTIGQ KSPSCVKVAL AAIRRARSHR SLSEALNQEY
RVSLRCLAAP DLVEGIRAQV IDKDRTPRWN PAVLEQVDDA TVEGYLAPLT DVAELGLEGE
R
//
