ID A0A1Y2Q5M5_9BURK Unreviewed; 583 AA.
AC A0A1Y2Q5M5;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
GN ORFNames=CAP38_14325 {ECO:0000313|EMBL:OSZ62932.1};
OS Hydrogenophaga sp. IBVHS2.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Hydrogenophaga.
OX NCBI_TaxID=1985170 {ECO:0000313|EMBL:OSZ62932.1, ECO:0000313|Proteomes:UP000243193};
RN [1] {ECO:0000313|EMBL:OSZ62932.1, ECO:0000313|Proteomes:UP000243193}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBVHS2 {ECO:0000313|EMBL:OSZ62932.1,
RC ECO:0000313|Proteomes:UP000243193};
RA Orr R.J.;
RT "Draft genome sequences of novel bacteria, isolated from environmental
RT samples.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OSZ62932.1}.
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DR EMBL; NFUT01000006; OSZ62932.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2Q5M5; -.
DR STRING; 1985170.CAP38_14325; -.
DR OrthoDB; 9767858at2; -.
DR Proteomes; UP000243193; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd07897; Adenylation_DNA_ligase_Bac1; 1.
DR Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR026333; ATP_dep_DNA_lig_pp_1105_fam.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR InterPro; IPR036599; DNA_ligase_N_sf.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR NCBIfam; TIGR04120; DNA_lig_bact; 1.
DR PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR PANTHER; PTHR45674:SF13; DNA LIGASE-RELATED; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF04675; DNA_ligase_A_N; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:OSZ62932.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000243193}.
FT DOMAIN 329..465
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
SQ SEQUENCE 583 AA; 63963 MW; EB809F34DE3A1332 CRC64;
MKDFADLYAE LDATTSTQAK VAALVRHFAR VGPADAAWAA YFLSGGKPRQ LIRTAQLRAL
ATEAAGLPDW LFEASYQAVG DLAETIALVL PPPDGTAGEA LGLADWMAQR LLPLRGQDEA
AVAAQLRAWW RELGPLSRFL LIKLVGGGFR VGVSKLLVQR AVAEHAGLDP KLVAARMMGY
TDGRRLPQAE DWQRITALTD ADGPAGPTDA APSQPYPFFL AQPLQDEPSA VLGVATDWRA
EWKFDGIRGQ IVRRGGQTWV WSRGEELMTD RFPELQALAA GWPDGTVVDG EIVVWDESLP
PLPGIDRPGR PAGFAVLQQR IGRQKLTASV LARAPVGFVA YDLLEQGGVD LRGEPLDLRR
ERLQDLAAAV APRLWLSPLH RADDWATLAR RREQSRDLGV EGLMLKHRAS TYGVGRHKQT
EGDQALGWWK WKIDPLTVDG VLIYAQAGHG RRASVYTDYT FAVWNRPPRD AAEAQAVVEA
IAARQPPAPD GLQLVAFTKA YSGLTDEVFK AVDAVIRKTT LEKFGPVRSV RPTLVFELAF
EGIARSSRHK SGVALRFPRM LRLRTDKPLH EAGTLPELES LLR
//
