ID A0A1Y2QJ49_9BURK Unreviewed; 304 AA.
AC A0A1Y2QJ49;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:OSZ67410.1};
GN ORFNames=CAP38_01105 {ECO:0000313|EMBL:OSZ67410.1};
OS Hydrogenophaga sp. IBVHS2.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Hydrogenophaga.
OX NCBI_TaxID=1985170 {ECO:0000313|EMBL:OSZ67410.1, ECO:0000313|Proteomes:UP000243193};
RN [1] {ECO:0000313|EMBL:OSZ67410.1, ECO:0000313|Proteomes:UP000243193}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBVHS2 {ECO:0000313|EMBL:OSZ67410.1,
RC ECO:0000313|Proteomes:UP000243193};
RA Orr R.J.;
RT "Draft genome sequences of novel bacteria, isolated from environmental
RT samples.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OSZ67410.1}.
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DR EMBL; NFUT01000001; OSZ67410.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2QJ49; -.
DR STRING; 1985170.CAP38_01105; -.
DR Proteomes; UP000243193; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000243193}.
FT DOMAIN 18..172
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 177..293
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 183
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 304 AA; 31680 MW; 93D5513D5CDF7053 CRC64;
MTQTSTPSAP APSSNLHVAV LGIGMMGFPM ARRLCEAGMV VSVWNRSRTK AERLLPFGAR
VADTPADAVA QADVVITLLE DGGIVEDVLF RQGAAQAMRP GCIVMDMSSI QPAQARDHAA
RLGALGVHHI DAPVSGGTLG AEQGTLAIMA GGKVADVERV QPVLAVLGRS THVGPHGAGQ
LAKLANQMIV GITIGAVAEA LLLCEKGGAD MARVKQAITG GFADSRILQV HGQRMIERDF
AKRGAVSVQL KDMRNALATA QEVGFNAPIT TLFEQLFAEA AEHGLADLDH SALFVELASR
NGMA
//
